Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration

Bone marrow (BM) perivascular stromal cells and vascular endothelial cells (ECs) are essential for hematopoietic stem cell (HSC) maintenance, but the roles of distinct niche compartments during HSC regeneration are less understood. Here we show that Leptin receptor-expressing (LepR+) BM stromal cell...

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Veröffentlicht in:	Cell stem cell 2018-09, Vol.23 (3), p.370-381.e5
Hauptverfasser:	Himburg, Heather A., Termini, Christina M., Schlussel, Lauren, Kan, Jenny, Li, Michelle, Zhao, Liman, Fang, Tiancheng, Sasine, Joshua P., Chang, Vivian Y., Chute, John P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow - metabolism Carrier Proteins - metabolism Cell Self Renewal Cytokines - deficiency Cytokines - metabolism endothelial cells Female hematopoiesis Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Male Mice Mice, Inbred C57BL microenvironment niche pleiotrophin regeneration self-renewal stem cells
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