Elevation of O-GlcNAc and GFAT expression by nicotine exposure promotes epithelial‐mesenchymal transition and invasion in breast cancer cells

Cigarette smoking has been shown to be a carcinogenic factor in breast cancer. Nicotine (Nic), an active component of tobacco, has been found to induce epithelial-mesenchymal transition (EMT) in breast cancer cells. However, the alterations in protein O-GlcNAcylation in Nic-mediated tumorigenesis an...

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Veröffentlicht in:	Cell death & disease 2019-04, Vol.10 (5), p.343, Article 343
Hauptverfasser:	Zhang, Nana, Zhu, Tong, Yu, Kairan, Shi, Meiyun, Wang, Xue, Wang, Lingyan, Huang, Tianmiao, Li, Wenli, Liu, Yubo, Zhang, Jianing
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/109 13/95 38/77 38/89 631/67/1347 631/80/458 631/80/84 82/29 82/58 96/109 96/95 Acylation Antibodies Biochemistry Biomedical and Life Sciences Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology CCAAT-Enhancer-Binding Protein-beta - metabolism CCAAT/enhancer-binding protein Cell activation Cell Biology Cell Culture Cell differentiation Cell Line, Tumor Cell migration Cell Movement - drug effects Cigarette smoking Deoxyribonucleic acid DNA Epithelial-Mesenchymal Transition - drug effects Epithelium Female Fructose Fructose-6-phosphate Gene regulation Glutamine Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - antagonists & inhibitors Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - genetics Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) - metabolism Humans Immunology Life Sciences Mesenchyme N-Acetylglucosaminyltransferases - antagonists & inhibitors N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism Nicotine Nicotine - pharmacology O-GlcNAcylation Promoter Regions, Genetic Protein B Proteins RNA Interference RNA, Small Interfering - metabolism Tobacco Transcription Transcription Factor CHOP - metabolism Tumorigenesis
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