Prevention of Injury‐Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR

ABSTRACT Traumatic joint injuries produce osteoarthritic cartilage manifesting accelerated chondrocyte terminal differentiation and matrix degradation via unknown cellular and molecular mechanisms. Here we report the ability of biomechanical stress to increase expression of the calcium‐sensing recep...

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Veröffentlicht in:	Journal of bone and mineral research 2019-04, Vol.34 (4), p.726-738
Hauptverfasser:	Zhang, Mian, Yang, Hongxu, Wan, Xianghong, Lu, Lei, Zhang, Jing, Zhang, Hongyun, Ye, Tao, Liu, Qian, Xie, Mianjiao, Liu, Xiaodong, Yu, Shibin, Guo, Shaoxiong, Chang, Wenhan, Wang, Meiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Calcium-sensing receptors CALCIUM‐SENSING RECEPTOR Cartilage diseases CHONDROCYTE DIFFERENTIATION Chondrocytes Chondrocytes - metabolism Chondrocytes - pathology Chondrogenesis DENTAL MALOCCLUSION Dental occlusion Endoplasmic reticulum Female Fluid flow Localization Male Mechanical loading Mechanical stimuli Mice Mice, Knockout Molecular modelling Naphthalenes - pharmacology OSTEOARTHRITIS Osteoarthritis - etiology Osteoarthritis - genetics Osteoarthritis - metabolism Osteoarthritis - prevention & control Phenotypes Rats Rats, Sprague-Dawley Receptors, Calcium-Sensing - antagonists & inhibitors Receptors, Calcium-Sensing - genetics Receptors, Calcium-Sensing - metabolism TEMPOROMANDIBULAR JOINT Temporomandibular Joint - injuries Temporomandibular Joint - metabolism Temporomandibular Joint Disorders - complications Temporomandibular Joint Disorders - drug therapy Temporomandibular Joint Disorders - genetics Temporomandibular Joint Disorders - metabolism
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