Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout

Recently, recessive mutations of MAGI2 were identified as a cause of steroid-resistant nephrotic syndrome (SRNS) in humans and mice. To further delineate the pathogenesis of MAGI2 loss of function, we generated stable knockout lines for the two zebrafish orthologues magi2a and magi2b by CRISPR/Cas9....

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Veröffentlicht in:	Kidney international 2019-05, Vol.95 (5), p.1079-1090
Hauptverfasser:	Jobst-Schwan, Tilman, Hoogstraten, Charlotte A., Kolvenbach, Caroline M., Schmidt, Johanna Magdalena, Kolb, Amy, Eddy, Kaitlyn, Schneider, Ronen, Ashraf, Shazia, Widmeier, Eugen, Majmundar, Amar J., Hildebrandt, Friedhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified chronic kidney disease Cyclosporine - pharmacology Cyclosporine - therapeutic use Disease Models, Animal Disease Progression Drug Resistance focal segmental glomerulosclerosis Gene Knockout Techniques Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use kidney development Membrane Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Nephrotic Syndrome - drug therapy Nephrotic Syndrome - genetics Nephrotic Syndrome - pathology podocyte Podocytes - drug effects Podocytes - pathology proteinuria Proteinuria - drug therapy Proteinuria - genetics Proteinuria - pathology Signal Transduction - drug effects Tacrolimus - pharmacology Tacrolimus - therapeutic use Treatment Outcome Zebrafish Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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