The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases

Activated protein C (APC) is a vitamin-K dependent plasma serine protease, which functions as a natural anticoagulant to downregulate thrombin generation in the clotting cascade. APC also modulates cellular homeostasis by exhibiting potent cytoprotective and anti-inflammatory signaling activities. T...

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Veröffentlicht in:	International journal of molecular sciences 2019-04, Vol.20 (7), p.1762
Hauptverfasser:	Ren, Di, Giri, Hemant, Li, Ji, Rezaie, Alireza R
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated protein C Animals Anticoagulants Anticoagulants - metabolism Apoptosis Arrestin Binding sites Blood Coagulation Calcium (reticular) Cardiovascular disease Caspase-8 Cell adhesion Cell adhesion & migration Cell adhesion molecules Coagulation Congestive heart failure Coronary artery disease Cytokines E-selectin Endoplasmic reticulum Endothelial cells Endothelial Protein C Receptor - metabolism Epidermal growth factor Genes Heart Heart Failure - metabolism Heart Failure - pathology Humans IL-1β Inflammation Intercellular adhesion molecule 1 Interleukin 6 Ischemia Kinases Mechanistic Target of Rapamycin Complex 1 - metabolism Myocardial Ischemia - metabolism Myocardial Ischemia - pathology NF-κB protein Nuclear transport Occupancy Oxidative stress Permeability Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein C - metabolism Proteins Receptor, PAR-1 - metabolism Review Signal Transduction Thrombin Thrombosis Tumor necrosis factor-α Vascular cell adhesion molecule 1 Vascular system
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