Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells
In pregnancy, excessive inflammation and break down of immunologic tolerance can contribute to miscarriage. Endothelial cells (ECs) are able to orchestrate the inflammatory processes by secreting pro-inflammatory mediators and bactericidal factors by modulating leakiness and leukocyte trafficking, v...
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| Veröffentlicht in: | International journal of molecular sciences 2019-03, Vol.20 (7), p.1604 |
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| creator | Agostinis, Chiara Masat, Elisa Bossi, Fleur Ricci, Giuseppe Menegazzi, Renzo Lombardelli, Letizia Zito, Gabriella Mangogna, Alessandro Degan, Massimo Gattei, Valter Piccinni, Marie-Pierre Kishore, Uday Bulla, Roberta |
| description | In pregnancy, excessive inflammation and break down of immunologic tolerance can contribute to miscarriage. Endothelial cells (ECs) are able to orchestrate the inflammatory processes by secreting pro-inflammatory mediators and bactericidal factors by modulating leakiness and leukocyte trafficking, via the expression of adhesion molecules and chemokines. The aim of this study was to analyse the differences in the phenotype between microvascular ECs isolated from decidua (DECs) and ECs isolated from human skin (ADMECs).
DECs and ADMECs were characterized for their basal expression of angiogenic factors and adhesion molecules. A range of immunological responses was evaluated, such as vessel leakage, reactive oxygen species (ROS) production in response to TNF-α stimulation, adhesion molecules expression and leukocyte migration in response to TNF-α and IFN-γ stimulation.
DECs produced higher levels of HGF, VEGF-A and IGFBP3 compared to ADMECs. DECs expressed adhesion molecules, ICAM-2 and ICAM-3, and a mild response to TNF-α was observed. Finally, DECs produced high levels of CXCL9/MIG and CXCL10/IP-10 in response to IFN-γ and selectively recruited Treg lymphocytes.
DEC phenotype differs considerably from that of ADMECs, suggesting that DECs may play an active role in the control of immune response and angiogenesis at the foetal-maternal interface. |
| doi_str_mv | 10.3390/ijms20071604 |
| format | Article |
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DECs and ADMECs were characterized for their basal expression of angiogenic factors and adhesion molecules. A range of immunological responses was evaluated, such as vessel leakage, reactive oxygen species (ROS) production in response to TNF-α stimulation, adhesion molecules expression and leukocyte migration in response to TNF-α and IFN-γ stimulation.
DECs produced higher levels of HGF, VEGF-A and IGFBP3 compared to ADMECs. DECs expressed adhesion molecules, ICAM-2 and ICAM-3, and a mild response to TNF-α was observed. Finally, DECs produced high levels of CXCL9/MIG and CXCL10/IP-10 in response to IFN-γ and selectively recruited Treg lymphocytes.
DEC phenotype differs considerably from that of ADMECs, suggesting that DECs may play an active role in the control of immune response and angiogenesis at the foetal-maternal interface.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20071604</identifier><identifier>PMID: 30935090</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Angiogenesis ; Cell activation ; Chemokines ; CXCL10 protein ; Cytokines ; Decidua ; Dendritic cells ; Endothelial cells ; Gene expression ; Genotype & phenotype ; Growth factors ; Immune system ; Immunology ; Immunoregulation ; Inflammation ; Interleukin 12 ; Interleukin 18 ; Interleukin 8 ; IP-10 protein ; Lymphocytes ; Lymphocytes T ; Macrophages ; Monocytes ; Natural killer cells ; Peripheral blood ; Permeability ; Phenotypes ; Plasma levels ; Pregnancy ; Recruitment ; Skin ; Tumor necrosis factor-α ; Uterus ; γ-Interferon</subject><ispartof>International journal of molecular sciences, 2019-03, Vol.20 (7), p.1604</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-85c9e30f7011ffbf630fec216658b7daeb2b678ba168f1f5e66eb414e52b18663</citedby><cites>FETCH-LOGICAL-c412t-85c9e30f7011ffbf630fec216658b7daeb2b678ba168f1f5e66eb414e52b18663</cites><orcidid>0000-0003-1737-5776 ; 0000-0003-1810-5209 ; 0000-0001-7910-1274 ; 0000-0002-7836-4934 ; 0000-0001-5096-1895</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479455/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479455/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30935090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agostinis, Chiara</creatorcontrib><creatorcontrib>Masat, Elisa</creatorcontrib><creatorcontrib>Bossi, Fleur</creatorcontrib><creatorcontrib>Ricci, Giuseppe</creatorcontrib><creatorcontrib>Menegazzi, Renzo</creatorcontrib><creatorcontrib>Lombardelli, Letizia</creatorcontrib><creatorcontrib>Zito, Gabriella</creatorcontrib><creatorcontrib>Mangogna, Alessandro</creatorcontrib><creatorcontrib>Degan, Massimo</creatorcontrib><creatorcontrib>Gattei, Valter</creatorcontrib><creatorcontrib>Piccinni, Marie-Pierre</creatorcontrib><creatorcontrib>Kishore, Uday</creatorcontrib><creatorcontrib>Bulla, Roberta</creatorcontrib><title>Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>In pregnancy, excessive inflammation and break down of immunologic tolerance can contribute to miscarriage. Endothelial cells (ECs) are able to orchestrate the inflammatory processes by secreting pro-inflammatory mediators and bactericidal factors by modulating leakiness and leukocyte trafficking, via the expression of adhesion molecules and chemokines. The aim of this study was to analyse the differences in the phenotype between microvascular ECs isolated from decidua (DECs) and ECs isolated from human skin (ADMECs).
DECs and ADMECs were characterized for their basal expression of angiogenic factors and adhesion molecules. A range of immunological responses was evaluated, such as vessel leakage, reactive oxygen species (ROS) production in response to TNF-α stimulation, adhesion molecules expression and leukocyte migration in response to TNF-α and IFN-γ stimulation.
DECs produced higher levels of HGF, VEGF-A and IGFBP3 compared to ADMECs. DECs expressed adhesion molecules, ICAM-2 and ICAM-3, and a mild response to TNF-α was observed. Finally, DECs produced high levels of CXCL9/MIG and CXCL10/IP-10 in response to IFN-γ and selectively recruited Treg lymphocytes.
DEC phenotype differs considerably from that of ADMECs, suggesting that DECs may play an active role in the control of immune response and angiogenesis at the foetal-maternal interface.</description><subject>Angiogenesis</subject><subject>Cell activation</subject><subject>Chemokines</subject><subject>CXCL10 protein</subject><subject>Cytokines</subject><subject>Decidua</subject><subject>Dendritic cells</subject><subject>Endothelial cells</subject><subject>Gene expression</subject><subject>Genotype & phenotype</subject><subject>Growth factors</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunoregulation</subject><subject>Inflammation</subject><subject>Interleukin 12</subject><subject>Interleukin 18</subject><subject>Interleukin 8</subject><subject>IP-10 protein</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Macrophages</subject><subject>Monocytes</subject><subject>Natural killer cells</subject><subject>Peripheral blood</subject><subject>Permeability</subject><subject>Phenotypes</subject><subject>Plasma levels</subject><subject>Pregnancy</subject><subject>Recruitment</subject><subject>Skin</subject><subject>Tumor necrosis 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Sci</addtitle><date>2019-03-31</date><risdate>2019</risdate><volume>20</volume><issue>7</issue><spage>1604</spage><pages>1604-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>In pregnancy, excessive inflammation and break down of immunologic tolerance can contribute to miscarriage. Endothelial cells (ECs) are able to orchestrate the inflammatory processes by secreting pro-inflammatory mediators and bactericidal factors by modulating leakiness and leukocyte trafficking, via the expression of adhesion molecules and chemokines. The aim of this study was to analyse the differences in the phenotype between microvascular ECs isolated from decidua (DECs) and ECs isolated from human skin (ADMECs).
DECs and ADMECs were characterized for their basal expression of angiogenic factors and adhesion molecules. A range of immunological responses was evaluated, such as vessel leakage, reactive oxygen species (ROS) production in response to TNF-α stimulation, adhesion molecules expression and leukocyte migration in response to TNF-α and IFN-γ stimulation.
DECs produced higher levels of HGF, VEGF-A and IGFBP3 compared to ADMECs. DECs expressed adhesion molecules, ICAM-2 and ICAM-3, and a mild response to TNF-α was observed. Finally, DECs produced high levels of CXCL9/MIG and CXCL10/IP-10 in response to IFN-γ and selectively recruited Treg lymphocytes.
DEC phenotype differs considerably from that of ADMECs, suggesting that DECs may play an active role in the control of immune response and angiogenesis at the foetal-maternal interface.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30935090</pmid><doi>10.3390/ijms20071604</doi><orcidid>https://orcid.org/0000-0003-1737-5776</orcidid><orcidid>https://orcid.org/0000-0003-1810-5209</orcidid><orcidid>https://orcid.org/0000-0001-7910-1274</orcidid><orcidid>https://orcid.org/0000-0002-7836-4934</orcidid><orcidid>https://orcid.org/0000-0001-5096-1895</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Angiogenesis Cell activation Chemokines CXCL10 protein Cytokines Decidua Dendritic cells Endothelial cells Gene expression Genotype & phenotype Growth factors Immune system Immunology Immunoregulation Inflammation Interleukin 12 Interleukin 18 Interleukin 8 IP-10 protein Lymphocytes Lymphocytes T Macrophages Monocytes Natural killer cells Peripheral blood Permeability Phenotypes Plasma levels Pregnancy Recruitment Skin Tumor necrosis factor-α Uterus γ-Interferon |
| title | Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells |
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