Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4

Oxidant-induced endothelial injury plays a critical role in the pathogenesis of acute lung injury (ALI) and subsequent respiratory failure. Our previous studies revealed an endogenous antioxidant and protective pathway in lung endothelium mediated by heat shock protein 70 (Hsp70)-toll-like receptor...

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Veröffentlicht in:	Antioxidants & redox signaling 2019-05, Vol.30 (15), p.1775-1796
Hauptverfasser:	Zhang, Yi, Shan, Peiying, Srivastava, Anup, Li, Zhenyu, Lee, Patty J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Bioenergetics Calcium Calcium (mitochondrial) Endothelial cells Endothelium Glycolysis Heat shock proteins Hsp70 protein Hyperoxia Immune system Injury prevention Innovations Lungs Lymphocytes B Mitochondria NF-κB protein Original Research Communications Pathogenesis Physiology Regulators Stanniocalcin TLR4 protein Toll-like receptors
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