TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2

Naive CD4 T lymphocytes differentiate into various Th cell subsets following TCR binding to microbial peptide:MHC class II (p:MHCII) complexes on dendritic cells (DCs). The affinity of the TCR interaction with p:MHCII plays a role in Th differentiation by mechanisms that are not completely understoo...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-05, Vol.202 (9), p.2535-2545
Hauptverfasser:	Kotov, Dmitri I, Mitchell, Jason S, Pengo, Thomas, Ruedl, Christiane, Way, Sing Sing, Langlois, Ryan A, Fife, Brian T, Jenkins, Marc K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Differentiation - immunology Dendritic Cells - cytology Dendritic Cells - immunology Gene Expression Regulation - genetics Gene Expression Regulation - immunology GTP-Binding Proteins - genetics GTP-Binding Proteins - immunology Interleukin-2 Receptor alpha Subunit - genetics Interleukin-2 Receptor alpha Subunit - immunology Mice Mice, Knockout Peptide Elongation Factors - genetics Peptide Elongation Factors - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Signal Transduction - genetics Signal Transduction - immunology Th1 Cells - cytology Th1 Cells - immunology Th2 Cells - cytology Th2 Cells - immunology
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