Selective progesterone receptor modulators (SPRMs) for uterine fibroids
Background Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone re...
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| creator | Murji, Ally Whitaker, Lucy Chow, Tiffany L Sobel, Mara L Murji, Ally |
| description | Background
Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible. This review summarises randomised trials conducted to evaluate the effectiveness of SPRMs as a class of medication for treatment of individuals with fibroids.
Objectives
To evaluate the effectiveness and safety of SPRMs for treatment of premenopausal women with uterine fibroids.
Search methods
We searched the Specialised Register of the Cochrane Gynaecology and Fertility Group, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and clinical trials registries from database inception to May 2016. We handsearched the reference lists of relevant articles and contacted experts in the field to request additional data.
Selection criteria
Included studies were randomised controlled trials (RCTs) of premenopausal women with fibroids who were treated for at least three months with a SPRM.
Data collection and analysis
Two review authors independently reviewed all eligible studies identified by the search. We extracted data and assessed risk of bias independently using standard forms. We analysed data using mean differences (MDs) or standardised mean differences (SMDs) for continuous data and odds ratios (ORs) for dichotomous data. We performed meta‐analyses using the random‐effects model. Our primary outcome was change in fibroid‐related symptoms.
Main results
We included in the review 14 RCTs with a total of 1215 study participants. We could not extract complete data from three studies. We included in the meta‐analysis 11 studies involving 1021 study participants: 685 received SPRMs and 336 were given a control intervention (placebo or leuprolide). Investigators evaluated three SPRMs: mifepristone (five studies), ulipristal acetate (four studies) and asoprisnil (two studies). The primary outcome was change in fibroid‐related symptoms (symptom seve |
| doi_str_mv | 10.1002/14651858.CD010770.pub2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6478099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1892334659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4732-1cccbe1b00848d49027618def514990fd7a47668b691fef15d8a2846716de6913</originalsourceid><addsrcrecordid>eNqFUctOwzAQtBCIlsIvVDmWQ4qduLZzQYICBakIROFsJc6mNUrrYDdF_Xsc9aHChdOudmZn9oFQl-A-wTi6IpQNiBiI_vAOE8w57ld1Fh2hdgOEDXJ8kLfQmXOfGMcsifgpakWCUspj1kajCZSglnoFQWXNFNwSrFlAYEFBtTQ2mJu8LlOfuaA3eX17dpdB4cu152nPK3Rmjc7dOTop0tLBxTZ20MfD_fvwMRy_jJ6GN-NQeb8oJEqpDEiGsaAipwmOOCMih2JAaJLgIucp5YyJjCWkgIIMcpH6YRknLAdfizvoeqPr151DrmCxtGkpK6vnqV1Lk2r5G1nomZyalWSUC5wkXqC3FbDmq_b7yrl2CsoyXYCpnSQiieLYH66hsg1VWeOchWJvQ7BsviB3X5C7LzTmkW_sHg65b9ud3RNuN4RvXcJaKqNm1vv_o_vH5Qdoj5iJ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1892334659</pqid></control><display><type>article</type><title>Selective progesterone receptor modulators (SPRMs) for uterine fibroids</title><source>MEDLINE</source><source>Cochrane Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Murji, Ally ; Whitaker, Lucy ; Chow, Tiffany L ; Sobel, Mara L ; Murji, Ally</creator><creatorcontrib>Murji, Ally ; Whitaker, Lucy ; Chow, Tiffany L ; Sobel, Mara L ; Murji, Ally</creatorcontrib><description>Background
Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible. This review summarises randomised trials conducted to evaluate the effectiveness of SPRMs as a class of medication for treatment of individuals with fibroids.
Objectives
To evaluate the effectiveness and safety of SPRMs for treatment of premenopausal women with uterine fibroids.
Search methods
We searched the Specialised Register of the Cochrane Gynaecology and Fertility Group, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and clinical trials registries from database inception to May 2016. We handsearched the reference lists of relevant articles and contacted experts in the field to request additional data.
Selection criteria
Included studies were randomised controlled trials (RCTs) of premenopausal women with fibroids who were treated for at least three months with a SPRM.
Data collection and analysis
Two review authors independently reviewed all eligible studies identified by the search. We extracted data and assessed risk of bias independently using standard forms. We analysed data using mean differences (MDs) or standardised mean differences (SMDs) for continuous data and odds ratios (ORs) for dichotomous data. We performed meta‐analyses using the random‐effects model. Our primary outcome was change in fibroid‐related symptoms.
Main results
We included in the review 14 RCTs with a total of 1215 study participants. We could not extract complete data from three studies. We included in the meta‐analysis 11 studies involving 1021 study participants: 685 received SPRMs and 336 were given a control intervention (placebo or leuprolide). Investigators evaluated three SPRMs: mifepristone (five studies), ulipristal acetate (four studies) and asoprisnil (two studies). The primary outcome was change in fibroid‐related symptoms (symptom severity, health‐related quality of life, abnormal uterine bleeding, pelvic pain). Adverse event reporting in the included studies was limited to SPRM‐associated endometrial changes. More than half (8/14) of these studies were at low risk of bias in all domains. The most common limitation of the other studies was poor reporting of methods. The main limitation for the overall quality of evidence was potential publication bias.
SPRM versus placebo
SPRM treatment resulted in improvements in fibroid symptom severity (MD ‐20.04 points, 95% confidence interval (CI) ‐26.63 to ‐13.46; four RCTs, 171 women, I2 = 0%; moderate‐quality evidence) and health‐related quality of life (MD 22.52 points, 95% CI 12.87 to 32.17; four RCTs, 200 women, I2 = 63%; moderate‐quality evidence) on the Uterine Fibroid Symptom Quality of Life Scale (UFS‐QoL, scale 0 to 100). Women treated with an SPRM showed reduced menstrual blood loss on patient‐reported bleeding scales, although this effect was small (SMD ‐1.11, 95% CI ‐1.38 to ‐0.83; three RCTs, 310 women, I2 = 0%; moderate‐quality evidence), along with higher rates of amenorrhoea (29 per 1000 in the placebo group vs 237 to 961 per 1000 in the SPRM group; OR 82.50, 95% CI 37.01 to 183.90; seven RCTs, 590 women, I2 = 0%; moderate‐quality evidence), compared with those given placebo. We could draw no conclusions regarding changes in pelvic pain owing to variability in the estimates. With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after placebo (OR 15.12, 95% CI 6.45 to 35.47; five RCTs, 405 women, I2 = 0%; low‐quality evidence).
SPRM versus leuprolide acetate
In comparing SPRM versus other treatments, two RCTs evaluated SPRM versus leuprolide acetate. One RCT reported primary outcomes. No evidence suggested a difference between SPRM and leuprolide groups for improvement in quality of life, as measured by UFS‐QoL fibroid symptom severity scores (MD ‐3.70 points, 95% CI ‐9.85 to 2.45; one RCT, 281 women; moderate‐quality evidence) and health‐related quality of life scores (MD 1.06 points, 95% CI ‐5.73 to 7.85; one RCT, 281 women; moderate‐quality evidence). It was unclear whether results showed a difference between SPRM and leuprolide groups for reduction in menstrual blood loss based on the pictorial blood loss assessment chart (PBAC), as confidence intervals were wide (MD 6 points, 95% CI ‐40.95 to 50.95; one RCT, 281 women; low‐quality evidence), or for rates of amenorrhoea (804 per 1000 in the placebo group vs 732 to 933 per 1000 in the SPRM group; OR 1.14, 95% CI 0.60 to 2.16; one RCT, 280 women; moderate‐quality evidence). No evidence revealed differences between groups in pelvic pain scores based on the McGill Pain Questionnaire (scale 0 to 45) (MD ‐0.01 points, 95% CI ‐2.14 to 2.12; 281 women; moderate‐quality evidence). With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after leuprolide treatment (OR 10.45, 95% CI 5.38 to 20.33; 301 women; moderate‐quality evidence).
Authors' conclusions
Short‐term use of SPRMs resulted in improved quality of life, reduced menstrual bleeding and higher rates of amenorrhoea than were seen with placebo. Thus, SPRMs may provide effective treatment for women with symptomatic fibroids. Evidence derived from one RCT showed no difference between leuprolide acetate and SPRM with respect to improved quality of life and bleeding symptoms. Evidence was insufficient to show whether effectiveness was different between SPRMs and leuprolide. Investigators more frequently observed SPRM‐associated endometrial changes in women treated with SPRMs than in those treated with placebo or leuprolide acetate. As noted above, SPRM‐associated endometrial changes are benign, are not related to cancer and are not precancerous. Reporting bias may impact the conclusion of this meta‐analysis. Well‐designed RCTs comparing SPRMs versus other treatments are needed.</description><identifier>ISSN: 1465-1858</identifier><identifier>EISSN: 1465-1858</identifier><identifier>EISSN: 1469-493X</identifier><identifier>DOI: 10.1002/14651858.CD010770.pub2</identifier><identifier>PMID: 28444736</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Amenorrhea ; Amenorrhea - drug therapy ; Antineoplastic Agents, Hormonal ; Antineoplastic Agents, Hormonal - therapeutic use ; Estrenes ; Estrenes - therapeutic use ; EXCESSIVE MENSTRUAL BLEEDING ; Female ; Fibroids ; Gynaecology ; Humans ; Leiomyoma ; Leiomyoma - drug therapy ; Leuprolide ; Leuprolide - therapeutic use ; Medical Therapies ; Medicine General & Introductory Medical Sciences ; Menstruation ; Menstruation - drug effects ; Mifepristone ; Mifepristone - therapeutic use ; Norpregnadienes ; Norpregnadienes - therapeutic use ; Other hormones ; Oximes ; Oximes - therapeutic use ; Pelvic Pain ; Pelvic Pain - drug therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Receptors, Progesterone ; Receptors, Progesterone - antagonists & inhibitors ; TREATMENT OF FIBROIDS ; Uterine Neoplasms ; Uterine Neoplasms - drug therapy</subject><ispartof>Cochrane database of systematic reviews, 2017-04, Vol.2017 (4), p.CD010770-CD010770</ispartof><rights>Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4732-1cccbe1b00848d49027618def514990fd7a47668b691fef15d8a2846716de6913</citedby><cites>FETCH-LOGICAL-c4732-1cccbe1b00848d49027618def514990fd7a47668b691fef15d8a2846716de6913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28444736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murji, Ally</creatorcontrib><creatorcontrib>Whitaker, Lucy</creatorcontrib><creatorcontrib>Chow, Tiffany L</creatorcontrib><creatorcontrib>Sobel, Mara L</creatorcontrib><creatorcontrib>Murji, Ally</creatorcontrib><title>Selective progesterone receptor modulators (SPRMs) for uterine fibroids</title><title>Cochrane database of systematic reviews</title><addtitle>Cochrane Database Syst Rev</addtitle><description>Background
Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible. This review summarises randomised trials conducted to evaluate the effectiveness of SPRMs as a class of medication for treatment of individuals with fibroids.
Objectives
To evaluate the effectiveness and safety of SPRMs for treatment of premenopausal women with uterine fibroids.
Search methods
We searched the Specialised Register of the Cochrane Gynaecology and Fertility Group, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and clinical trials registries from database inception to May 2016. We handsearched the reference lists of relevant articles and contacted experts in the field to request additional data.
Selection criteria
Included studies were randomised controlled trials (RCTs) of premenopausal women with fibroids who were treated for at least three months with a SPRM.
Data collection and analysis
Two review authors independently reviewed all eligible studies identified by the search. We extracted data and assessed risk of bias independently using standard forms. We analysed data using mean differences (MDs) or standardised mean differences (SMDs) for continuous data and odds ratios (ORs) for dichotomous data. We performed meta‐analyses using the random‐effects model. Our primary outcome was change in fibroid‐related symptoms.
Main results
We included in the review 14 RCTs with a total of 1215 study participants. We could not extract complete data from three studies. We included in the meta‐analysis 11 studies involving 1021 study participants: 685 received SPRMs and 336 were given a control intervention (placebo or leuprolide). Investigators evaluated three SPRMs: mifepristone (five studies), ulipristal acetate (four studies) and asoprisnil (two studies). The primary outcome was change in fibroid‐related symptoms (symptom severity, health‐related quality of life, abnormal uterine bleeding, pelvic pain). Adverse event reporting in the included studies was limited to SPRM‐associated endometrial changes. More than half (8/14) of these studies were at low risk of bias in all domains. The most common limitation of the other studies was poor reporting of methods. The main limitation for the overall quality of evidence was potential publication bias.
SPRM versus placebo
SPRM treatment resulted in improvements in fibroid symptom severity (MD ‐20.04 points, 95% confidence interval (CI) ‐26.63 to ‐13.46; four RCTs, 171 women, I2 = 0%; moderate‐quality evidence) and health‐related quality of life (MD 22.52 points, 95% CI 12.87 to 32.17; four RCTs, 200 women, I2 = 63%; moderate‐quality evidence) on the Uterine Fibroid Symptom Quality of Life Scale (UFS‐QoL, scale 0 to 100). Women treated with an SPRM showed reduced menstrual blood loss on patient‐reported bleeding scales, although this effect was small (SMD ‐1.11, 95% CI ‐1.38 to ‐0.83; three RCTs, 310 women, I2 = 0%; moderate‐quality evidence), along with higher rates of amenorrhoea (29 per 1000 in the placebo group vs 237 to 961 per 1000 in the SPRM group; OR 82.50, 95% CI 37.01 to 183.90; seven RCTs, 590 women, I2 = 0%; moderate‐quality evidence), compared with those given placebo. We could draw no conclusions regarding changes in pelvic pain owing to variability in the estimates. With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after placebo (OR 15.12, 95% CI 6.45 to 35.47; five RCTs, 405 women, I2 = 0%; low‐quality evidence).
SPRM versus leuprolide acetate
In comparing SPRM versus other treatments, two RCTs evaluated SPRM versus leuprolide acetate. One RCT reported primary outcomes. No evidence suggested a difference between SPRM and leuprolide groups for improvement in quality of life, as measured by UFS‐QoL fibroid symptom severity scores (MD ‐3.70 points, 95% CI ‐9.85 to 2.45; one RCT, 281 women; moderate‐quality evidence) and health‐related quality of life scores (MD 1.06 points, 95% CI ‐5.73 to 7.85; one RCT, 281 women; moderate‐quality evidence). It was unclear whether results showed a difference between SPRM and leuprolide groups for reduction in menstrual blood loss based on the pictorial blood loss assessment chart (PBAC), as confidence intervals were wide (MD 6 points, 95% CI ‐40.95 to 50.95; one RCT, 281 women; low‐quality evidence), or for rates of amenorrhoea (804 per 1000 in the placebo group vs 732 to 933 per 1000 in the SPRM group; OR 1.14, 95% CI 0.60 to 2.16; one RCT, 280 women; moderate‐quality evidence). No evidence revealed differences between groups in pelvic pain scores based on the McGill Pain Questionnaire (scale 0 to 45) (MD ‐0.01 points, 95% CI ‐2.14 to 2.12; 281 women; moderate‐quality evidence). With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after leuprolide treatment (OR 10.45, 95% CI 5.38 to 20.33; 301 women; moderate‐quality evidence).
Authors' conclusions
Short‐term use of SPRMs resulted in improved quality of life, reduced menstrual bleeding and higher rates of amenorrhoea than were seen with placebo. Thus, SPRMs may provide effective treatment for women with symptomatic fibroids. Evidence derived from one RCT showed no difference between leuprolide acetate and SPRM with respect to improved quality of life and bleeding symptoms. Evidence was insufficient to show whether effectiveness was different between SPRMs and leuprolide. Investigators more frequently observed SPRM‐associated endometrial changes in women treated with SPRMs than in those treated with placebo or leuprolide acetate. As noted above, SPRM‐associated endometrial changes are benign, are not related to cancer and are not precancerous. Reporting bias may impact the conclusion of this meta‐analysis. Well‐designed RCTs comparing SPRMs versus other treatments are needed.</description><subject>Amenorrhea</subject><subject>Amenorrhea - drug therapy</subject><subject>Antineoplastic Agents, Hormonal</subject><subject>Antineoplastic Agents, Hormonal - therapeutic use</subject><subject>Estrenes</subject><subject>Estrenes - therapeutic use</subject><subject>EXCESSIVE MENSTRUAL BLEEDING</subject><subject>Female</subject><subject>Fibroids</subject><subject>Gynaecology</subject><subject>Humans</subject><subject>Leiomyoma</subject><subject>Leiomyoma - drug therapy</subject><subject>Leuprolide</subject><subject>Leuprolide - therapeutic use</subject><subject>Medical Therapies</subject><subject>Medicine General & Introductory Medical Sciences</subject><subject>Menstruation</subject><subject>Menstruation - drug effects</subject><subject>Mifepristone</subject><subject>Mifepristone - therapeutic use</subject><subject>Norpregnadienes</subject><subject>Norpregnadienes - therapeutic use</subject><subject>Other hormones</subject><subject>Oximes</subject><subject>Oximes - therapeutic use</subject><subject>Pelvic Pain</subject><subject>Pelvic Pain - drug therapy</subject><subject>Quality of Life</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Receptors, Progesterone</subject><subject>Receptors, Progesterone - antagonists & inhibitors</subject><subject>TREATMENT OF FIBROIDS</subject><subject>Uterine Neoplasms</subject><subject>Uterine Neoplasms - drug therapy</subject><issn>1465-1858</issn><issn>1465-1858</issn><issn>1469-493X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RWY</sourceid><sourceid>EIF</sourceid><recordid>eNqFUctOwzAQtBCIlsIvVDmWQ4qduLZzQYICBakIROFsJc6mNUrrYDdF_Xsc9aHChdOudmZn9oFQl-A-wTi6IpQNiBiI_vAOE8w57ld1Fh2hdgOEDXJ8kLfQmXOfGMcsifgpakWCUspj1kajCZSglnoFQWXNFNwSrFlAYEFBtTQ2mJu8LlOfuaA3eX17dpdB4cu152nPK3Rmjc7dOTop0tLBxTZ20MfD_fvwMRy_jJ6GN-NQeb8oJEqpDEiGsaAipwmOOCMih2JAaJLgIucp5YyJjCWkgIIMcpH6YRknLAdfizvoeqPr151DrmCxtGkpK6vnqV1Lk2r5G1nomZyalWSUC5wkXqC3FbDmq_b7yrl2CsoyXYCpnSQiieLYH66hsg1VWeOchWJvQ7BsviB3X5C7LzTmkW_sHg65b9ud3RNuN4RvXcJaKqNm1vv_o_vH5Qdoj5iJ</recordid><startdate>20170426</startdate><enddate>20170426</enddate><creator>Murji, Ally</creator><creator>Whitaker, Lucy</creator><creator>Chow, Tiffany L</creator><creator>Sobel, Mara L</creator><creator>Murji, Ally</creator><general>John Wiley & Sons, Ltd</general><scope>7PX</scope><scope>RWY</scope><scope>ZYTZH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170426</creationdate><title>Selective progesterone receptor modulators (SPRMs) for uterine fibroids</title><author>Murji, Ally ; Whitaker, Lucy ; Chow, Tiffany L ; Sobel, Mara L ; Murji, Ally</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4732-1cccbe1b00848d49027618def514990fd7a47668b691fef15d8a2846716de6913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amenorrhea</topic><topic>Amenorrhea - drug therapy</topic><topic>Antineoplastic Agents, Hormonal</topic><topic>Antineoplastic Agents, Hormonal - therapeutic use</topic><topic>Estrenes</topic><topic>Estrenes - therapeutic use</topic><topic>EXCESSIVE MENSTRUAL BLEEDING</topic><topic>Female</topic><topic>Fibroids</topic><topic>Gynaecology</topic><topic>Humans</topic><topic>Leiomyoma</topic><topic>Leiomyoma - drug therapy</topic><topic>Leuprolide</topic><topic>Leuprolide - therapeutic use</topic><topic>Medical Therapies</topic><topic>Medicine General & Introductory Medical Sciences</topic><topic>Menstruation</topic><topic>Menstruation - drug effects</topic><topic>Mifepristone</topic><topic>Mifepristone - therapeutic use</topic><topic>Norpregnadienes</topic><topic>Norpregnadienes - therapeutic use</topic><topic>Other hormones</topic><topic>Oximes</topic><topic>Oximes - therapeutic use</topic><topic>Pelvic Pain</topic><topic>Pelvic Pain - drug therapy</topic><topic>Quality of Life</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Receptors, Progesterone</topic><topic>Receptors, Progesterone - antagonists & inhibitors</topic><topic>TREATMENT OF FIBROIDS</topic><topic>Uterine Neoplasms</topic><topic>Uterine Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murji, Ally</creatorcontrib><creatorcontrib>Whitaker, Lucy</creatorcontrib><creatorcontrib>Chow, Tiffany L</creatorcontrib><creatorcontrib>Sobel, Mara L</creatorcontrib><creatorcontrib>Murji, Ally</creatorcontrib><collection>Wiley-Blackwell Cochrane Library</collection><collection>Cochrane Library</collection><collection>Cochrane Library (Open Aceess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cochrane database of systematic reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murji, Ally</au><au>Whitaker, Lucy</au><au>Chow, Tiffany L</au><au>Sobel, Mara L</au><au>Murji, Ally</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective progesterone receptor modulators (SPRMs) for uterine fibroids</atitle><jtitle>Cochrane database of systematic reviews</jtitle><addtitle>Cochrane Database Syst Rev</addtitle><date>2017-04-26</date><risdate>2017</risdate><volume>2017</volume><issue>4</issue><spage>CD010770</spage><epage>CD010770</epage><pages>CD010770-CD010770</pages><issn>1465-1858</issn><eissn>1465-1858</eissn><eissn>1469-493X</eissn><abstract>Background
Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible. This review summarises randomised trials conducted to evaluate the effectiveness of SPRMs as a class of medication for treatment of individuals with fibroids.
Objectives
To evaluate the effectiveness and safety of SPRMs for treatment of premenopausal women with uterine fibroids.
Search methods
We searched the Specialised Register of the Cochrane Gynaecology and Fertility Group, the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, PsycINFO, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and clinical trials registries from database inception to May 2016. We handsearched the reference lists of relevant articles and contacted experts in the field to request additional data.
Selection criteria
Included studies were randomised controlled trials (RCTs) of premenopausal women with fibroids who were treated for at least three months with a SPRM.
Data collection and analysis
Two review authors independently reviewed all eligible studies identified by the search. We extracted data and assessed risk of bias independently using standard forms. We analysed data using mean differences (MDs) or standardised mean differences (SMDs) for continuous data and odds ratios (ORs) for dichotomous data. We performed meta‐analyses using the random‐effects model. Our primary outcome was change in fibroid‐related symptoms.
Main results
We included in the review 14 RCTs with a total of 1215 study participants. We could not extract complete data from three studies. We included in the meta‐analysis 11 studies involving 1021 study participants: 685 received SPRMs and 336 were given a control intervention (placebo or leuprolide). Investigators evaluated three SPRMs: mifepristone (five studies), ulipristal acetate (four studies) and asoprisnil (two studies). The primary outcome was change in fibroid‐related symptoms (symptom severity, health‐related quality of life, abnormal uterine bleeding, pelvic pain). Adverse event reporting in the included studies was limited to SPRM‐associated endometrial changes. More than half (8/14) of these studies were at low risk of bias in all domains. The most common limitation of the other studies was poor reporting of methods. The main limitation for the overall quality of evidence was potential publication bias.
SPRM versus placebo
SPRM treatment resulted in improvements in fibroid symptom severity (MD ‐20.04 points, 95% confidence interval (CI) ‐26.63 to ‐13.46; four RCTs, 171 women, I2 = 0%; moderate‐quality evidence) and health‐related quality of life (MD 22.52 points, 95% CI 12.87 to 32.17; four RCTs, 200 women, I2 = 63%; moderate‐quality evidence) on the Uterine Fibroid Symptom Quality of Life Scale (UFS‐QoL, scale 0 to 100). Women treated with an SPRM showed reduced menstrual blood loss on patient‐reported bleeding scales, although this effect was small (SMD ‐1.11, 95% CI ‐1.38 to ‐0.83; three RCTs, 310 women, I2 = 0%; moderate‐quality evidence), along with higher rates of amenorrhoea (29 per 1000 in the placebo group vs 237 to 961 per 1000 in the SPRM group; OR 82.50, 95% CI 37.01 to 183.90; seven RCTs, 590 women, I2 = 0%; moderate‐quality evidence), compared with those given placebo. We could draw no conclusions regarding changes in pelvic pain owing to variability in the estimates. With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after placebo (OR 15.12, 95% CI 6.45 to 35.47; five RCTs, 405 women, I2 = 0%; low‐quality evidence).
SPRM versus leuprolide acetate
In comparing SPRM versus other treatments, two RCTs evaluated SPRM versus leuprolide acetate. One RCT reported primary outcomes. No evidence suggested a difference between SPRM and leuprolide groups for improvement in quality of life, as measured by UFS‐QoL fibroid symptom severity scores (MD ‐3.70 points, 95% CI ‐9.85 to 2.45; one RCT, 281 women; moderate‐quality evidence) and health‐related quality of life scores (MD 1.06 points, 95% CI ‐5.73 to 7.85; one RCT, 281 women; moderate‐quality evidence). It was unclear whether results showed a difference between SPRM and leuprolide groups for reduction in menstrual blood loss based on the pictorial blood loss assessment chart (PBAC), as confidence intervals were wide (MD 6 points, 95% CI ‐40.95 to 50.95; one RCT, 281 women; low‐quality evidence), or for rates of amenorrhoea (804 per 1000 in the placebo group vs 732 to 933 per 1000 in the SPRM group; OR 1.14, 95% CI 0.60 to 2.16; one RCT, 280 women; moderate‐quality evidence). No evidence revealed differences between groups in pelvic pain scores based on the McGill Pain Questionnaire (scale 0 to 45) (MD ‐0.01 points, 95% CI ‐2.14 to 2.12; 281 women; moderate‐quality evidence). With respect to adverse effects, SPRM‐associated endometrial changes were more common after SPRM therapy than after leuprolide treatment (OR 10.45, 95% CI 5.38 to 20.33; 301 women; moderate‐quality evidence).
Authors' conclusions
Short‐term use of SPRMs resulted in improved quality of life, reduced menstrual bleeding and higher rates of amenorrhoea than were seen with placebo. Thus, SPRMs may provide effective treatment for women with symptomatic fibroids. Evidence derived from one RCT showed no difference between leuprolide acetate and SPRM with respect to improved quality of life and bleeding symptoms. Evidence was insufficient to show whether effectiveness was different between SPRMs and leuprolide. Investigators more frequently observed SPRM‐associated endometrial changes in women treated with SPRMs than in those treated with placebo or leuprolide acetate. As noted above, SPRM‐associated endometrial changes are benign, are not related to cancer and are not precancerous. Reporting bias may impact the conclusion of this meta‐analysis. Well‐designed RCTs comparing SPRMs versus other treatments are needed.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>28444736</pmid><doi>10.1002/14651858.CD010770.pub2</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1465-1858 |
| ispartof | Cochrane database of systematic reviews, 2017-04, Vol.2017 (4), p.CD010770-CD010770 |
| issn | 1465-1858 1465-1858 1469-493X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6478099 |
| source | MEDLINE; Cochrane Library; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amenorrhea Amenorrhea - drug therapy Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal - therapeutic use Estrenes Estrenes - therapeutic use EXCESSIVE MENSTRUAL BLEEDING Female Fibroids Gynaecology Humans Leiomyoma Leiomyoma - drug therapy Leuprolide Leuprolide - therapeutic use Medical Therapies Medicine General & Introductory Medical Sciences Menstruation Menstruation - drug effects Mifepristone Mifepristone - therapeutic use Norpregnadienes Norpregnadienes - therapeutic use Other hormones Oximes Oximes - therapeutic use Pelvic Pain Pelvic Pain - drug therapy Quality of Life Randomized Controlled Trials as Topic Receptors, Progesterone Receptors, Progesterone - antagonists & inhibitors TREATMENT OF FIBROIDS Uterine Neoplasms Uterine Neoplasms - drug therapy |
| title | Selective progesterone receptor modulators (SPRMs) for uterine fibroids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T14%3A21%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Selective%20progesterone%20receptor%20modulators%20(SPRMs)%20for%20uterine%20fibroids&rft.jtitle=Cochrane%20database%20of%20systematic%20reviews&rft.au=Murji,%20Ally&rft.date=2017-04-26&rft.volume=2017&rft.issue=4&rft.spage=CD010770&rft.epage=CD010770&rft.pages=CD010770-CD010770&rft.issn=1465-1858&rft.eissn=1465-1858&rft_id=info:doi/10.1002/14651858.CD010770.pub2&rft_dat=%3Cproquest_pubme%3E1892334659%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1892334659&rft_id=info:pmid/28444736&rfr_iscdi=true |