NOD1: An Interface Between Innate Immunity and Insulin Resistance

Insulin resistance is driven, in part, by activation of the innate immune system. We have discussed the evidence linking nucleotide-binding oligomerization domain (NOD)1, an intracellular pattern recognition receptor, to the onset and progression of obesity-induced insulin resistance. On a molecular...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2019-05, Vol.160 (5), p.1021-1030
Hauptverfasser:	Rivers, Sydney L, Klip, Amira, Giacca, Adria
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Care and treatment Cell interactions Cellular signal transduction Crosstalk Development and progression Diet, High-Fat Endocrinology Health aspects High fat diet Identity Immune system Immunity, Innate - genetics Immunity, Innate - immunology Immunologic research In vivo methods and tests Inflammation Inflammation - genetics Inflammation - immunology Inflammation - metabolism Innate immunity Insulin Insulin resistance Insulin Resistance - immunology Ligands Lipids Macrophages Metabolic diseases Metabolism Metabolites Mice Mini-Review Models, Immunological NOD1 Nod1 protein Nod1 Signaling Adaptor Protein - genetics Nod1 Signaling Adaptor Protein - immunology Nod1 Signaling Adaptor Protein - metabolism Nucleotides Obesity Obesity - genetics Obesity - immunology Obesity - metabolism Oligomerization Oligomers Pattern recognition Pattern recognition receptors Permeability Physiological aspects Receptor, Insulin - metabolism Signal Transduction - genetics Signal Transduction - immunology Signaling Substrates Transcription factors Translocation Type 2 diabetes
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