TMOD-03. GAINING A MECHANISTIC UNDERSTANDING OF THERAPY EVASION FROM DUAL MAPK PATHWAY INHIBITION IN A SYNGENEIC BRAFV600E MUTANT CDKN2A DELETED MOUSE MODEL TO PREEMPT RESISTANCE IN PATIENTS WITH BRAFV600E MUTANT PEDIATRIC GLIOMA

Abstract Pediatric patients with gliomas expressing the constitutively active BRAFV600E-mutant kinase are candidates for clinical trials for small molecule inhibitors specific for BRAFV600E (BRAFi) and MEK (MEKi) (Grossauer et al; Oncotarget 2016, 15:75839). Clinical results from combined BRAF and M...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2019-04, Vol.21 (Supplement_2), p.ii121-ii122
Hauptverfasser:	Wang, Wei, Grossauer, Stefan, Koeck, Katharina, Simonds, Erin, Lu, Edbert, Bergers, Gabriele, Weiss, William, Petritsch, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Pediatric Brain Tumor Models
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!