Expanding the donor lung pool: how many donation after circulatory death organs are we missing?
The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is...
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| Veröffentlicht in: | The Journal of surgical research 2018-03, Vol.223, p.58-63 |
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| container_title | The Journal of surgical research |
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| creator | Chancellor, William Zachary Charles, Eric J. Mehaffey, James Hunter Hawkins, Robert B. Foster, Carrie A. Sharma, Ashish K. Laubach, Victor E. Kron, Irving L. Tribble, Curtis G. |
| description | The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is to determine the potential donor pool expansion with increased procurement of DCD organs from patients who die at hospitals.
The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy. Inclusion criteria were age |
| doi_str_mv | 10.1016/j.jss.2017.09.029 |
| format | Article |
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The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy. Inclusion criteria were age <65 y, absence of cancer and lung pathology, and cause of death other than respiratory or sepsis.
A total of 857 patients died within a 1-year period and were stratified by age: pediatric <15 y (n = 32, 4%), young 15-64 y (n = 328, 38%), and old >65 y (n = 497, 58%). Those without cancer totaled 778 (90.8%) and 512 (59%) did not have lung pathology. This leaves 85 patients qualifying for DCD lung donation (pediatric n = 10, young n = 75, and old n = 0). Potential donors were significantly more likely to have clear chest X-rays (24.3% versus 10.0%, P < 0.0001) and higher mean PaO2/FiO2 (342.1 versus 197.9, P < 0.0001) compared with ineligible patients.
A significant number of DCD lungs are available every year from patients who die within hospitals. We estimate the use of suitable DCD lungs could potentially result in a significant increase in the number of lungs available for transplantation.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2017.09.029</identifier><identifier>PMID: 29433886</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>Donation after circulatory death ; Donor pool size ; High-risk donation ; Lung transplantation</subject><ispartof>The Journal of surgical research, 2018-03, Vol.223, p.58-63</ispartof><rights>2017 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-d7bd2a14b6ba8454548b099d0e444839a5c7b964718dcac984e30685b6f07bd53</citedby><cites>FETCH-LOGICAL-c325t-d7bd2a14b6ba8454548b099d0e444839a5c7b964718dcac984e30685b6f07bd53</cites><orcidid>0000-0002-3959-8201</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jss.2017.09.029$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27922,27923,45993</link.rule.ids></links><search><creatorcontrib>Chancellor, William Zachary</creatorcontrib><creatorcontrib>Charles, Eric J.</creatorcontrib><creatorcontrib>Mehaffey, James Hunter</creatorcontrib><creatorcontrib>Hawkins, Robert B.</creatorcontrib><creatorcontrib>Foster, Carrie A.</creatorcontrib><creatorcontrib>Sharma, Ashish K.</creatorcontrib><creatorcontrib>Laubach, Victor E.</creatorcontrib><creatorcontrib>Kron, Irving L.</creatorcontrib><creatorcontrib>Tribble, Curtis G.</creatorcontrib><title>Expanding the donor lung pool: how many donation after circulatory death organs are we missing?</title><title>The Journal of surgical research</title><description>The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is to determine the potential donor pool expansion with increased procurement of DCD organs from patients who die at hospitals.
The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy. Inclusion criteria were age <65 y, absence of cancer and lung pathology, and cause of death other than respiratory or sepsis.
A total of 857 patients died within a 1-year period and were stratified by age: pediatric <15 y (n = 32, 4%), young 15-64 y (n = 328, 38%), and old >65 y (n = 497, 58%). Those without cancer totaled 778 (90.8%) and 512 (59%) did not have lung pathology. This leaves 85 patients qualifying for DCD lung donation (pediatric n = 10, young n = 75, and old n = 0). Potential donors were significantly more likely to have clear chest X-rays (24.3% versus 10.0%, P < 0.0001) and higher mean PaO2/FiO2 (342.1 versus 197.9, P < 0.0001) compared with ineligible patients.
A significant number of DCD lungs are available every year from patients who die within hospitals. We estimate the use of suitable DCD lungs could potentially result in a significant increase in the number of lungs available for transplantation.</description><subject>Donation after circulatory death</subject><subject>Donor pool size</subject><subject>High-risk donation</subject><subject>Lung transplantation</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kF1LwzAUhoMobk5_gHf5A60nbdomCoqM-QEDb_Q6pEm6ZXTJSLrp_r0ZE8EbOReHw8vzwHkRuiaQEyD1zSpfxZgXQJoceA4FP0FjArzKWN2Up2gMUBQZZUBH6CLGFaSbN-U5GhWcliVj9RiJ2ddGOm3dAg9Lg7V3PuB-m86N9_0tXvpPvJZuf0jkYL3DshtMwMoGte3l4EOKjByW2IeFdBHLYPCnwWsbY5I-XKKzTvbRXP3sCfp4mr1PX7L52_Pr9HGeqbKohkw3rS4koW3dSkarNKwFzjUYSikruaxU0_KaNoRpJRVn1JRQs6qtO0hoVU7Q_dG72bZro5VxQ5C92AS7lmEvvLTib-LsUiz8TiRnxaFJAnIUqOBjDKb7ZQmIQ9tiJVLb4tC2AC5SlYm5OzImfbazJoiorHHKaBuMGoT29h_6G6pXiLk</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Chancellor, William Zachary</creator><creator>Charles, Eric J.</creator><creator>Mehaffey, James Hunter</creator><creator>Hawkins, Robert B.</creator><creator>Foster, Carrie A.</creator><creator>Sharma, Ashish K.</creator><creator>Laubach, Victor E.</creator><creator>Kron, Irving L.</creator><creator>Tribble, Curtis G.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3959-8201</orcidid></search><sort><creationdate>20180301</creationdate><title>Expanding the donor lung pool: how many donation after circulatory death organs are we missing?</title><author>Chancellor, William Zachary ; Charles, Eric J. ; Mehaffey, James Hunter ; Hawkins, Robert B. ; Foster, Carrie A. ; Sharma, Ashish K. ; Laubach, Victor E. ; Kron, Irving L. ; Tribble, Curtis G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-d7bd2a14b6ba8454548b099d0e444839a5c7b964718dcac984e30685b6f07bd53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Donation after circulatory death</topic><topic>Donor pool size</topic><topic>High-risk donation</topic><topic>Lung transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chancellor, William Zachary</creatorcontrib><creatorcontrib>Charles, Eric J.</creatorcontrib><creatorcontrib>Mehaffey, James Hunter</creatorcontrib><creatorcontrib>Hawkins, Robert B.</creatorcontrib><creatorcontrib>Foster, Carrie A.</creatorcontrib><creatorcontrib>Sharma, Ashish K.</creatorcontrib><creatorcontrib>Laubach, Victor E.</creatorcontrib><creatorcontrib>Kron, Irving L.</creatorcontrib><creatorcontrib>Tribble, Curtis G.</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chancellor, William Zachary</au><au>Charles, Eric J.</au><au>Mehaffey, James Hunter</au><au>Hawkins, Robert B.</au><au>Foster, Carrie A.</au><au>Sharma, Ashish K.</au><au>Laubach, Victor E.</au><au>Kron, Irving L.</au><au>Tribble, Curtis G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expanding the donor lung pool: how many donation after circulatory death organs are we missing?</atitle><jtitle>The Journal of surgical research</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>223</volume><spage>58</spage><epage>63</epage><pages>58-63</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>The number of patients with end-stage pulmonary disease awaiting lung transplantation is at an all-time high, while the supply of available organs remains stagnant. Utilizing donation after circulatory death (DCD) donors may help to address the supply-demand mismatch. The objective of this study is to determine the potential donor pool expansion with increased procurement of DCD organs from patients who die at hospitals.
The charts of all patients who died at a single, rural, quaternary-care institution between August 2014 and June 2015 were reviewed for lung transplant candidacy. Inclusion criteria were age <65 y, absence of cancer and lung pathology, and cause of death other than respiratory or sepsis.
A total of 857 patients died within a 1-year period and were stratified by age: pediatric <15 y (n = 32, 4%), young 15-64 y (n = 328, 38%), and old >65 y (n = 497, 58%). Those without cancer totaled 778 (90.8%) and 512 (59%) did not have lung pathology. This leaves 85 patients qualifying for DCD lung donation (pediatric n = 10, young n = 75, and old n = 0). Potential donors were significantly more likely to have clear chest X-rays (24.3% versus 10.0%, P < 0.0001) and higher mean PaO2/FiO2 (342.1 versus 197.9, P < 0.0001) compared with ineligible patients.
A significant number of DCD lungs are available every year from patients who die within hospitals. We estimate the use of suitable DCD lungs could potentially result in a significant increase in the number of lungs available for transplantation.</abstract><pub>Elsevier Inc</pub><pmid>29433886</pmid><doi>10.1016/j.jss.2017.09.029</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-3959-8201</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 0022-4804 1095-8673 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings |
| subjects | Donation after circulatory death Donor pool size High-risk donation Lung transplantation |
| title | Expanding the donor lung pool: how many donation after circulatory death organs are we missing? |
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