PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study
IntroductionPostoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery. An excessive postoperative inflammatory response participates to the development of postoperative infection and mortality. The aim of the Periopera...
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| description | IntroductionPostoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery. An excessive postoperative inflammatory response participates to the development of postoperative infection and mortality. The aim of the Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac surgery (PACMAN) study is to assess the effectiveness of perioperative administration of corticosteroid to reduce postoperative morbidity and mortality in patients undergoing major non-cardiac surgery.Methods and analysisThe PACMAN is a multicentre, randomised, controlled, double-blind, superiority, two-arm trial of 1222 high-risk patients aged 50 years or older undergoing major non-cardiac surgery at 32 acute care hospital in France. Patients are randomly assigned to dexamethasone (0.2 mg/kg at the end of the surgical procedure and at day +1, n=611) or to placebo (n=611). The primary outcome is a composite of predefined 14-day major pulmonary complications and mortality. Secondary outcomes are surgical complications, infections, organ failures, critical care-free days, length of hospital stay and all-cause mortality at 28 days.Ethics and disseminationThe PACMAN trial protocol has been approved by the ethics committee of Sud Mediterranée V, and will be carried out according to the Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The PACMAN trial is a randomised controlled trial powered to investigate whether perioperative administration of corticosteroids in patients undergoing non-cardiac major surgery reduces postoperative complications. The results of this study will be disseminated through presentation at scientific conferences and publication in peer-reviewed journals.Trial registration numberNCT03218553; Pre-results. |
| doi_str_mv | 10.1136/bmjopen-2017-021262 |
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An excessive postoperative inflammatory response participates to the development of postoperative infection and mortality. The aim of the Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac surgery (PACMAN) study is to assess the effectiveness of perioperative administration of corticosteroid to reduce postoperative morbidity and mortality in patients undergoing major non-cardiac surgery.Methods and analysisThe PACMAN is a multicentre, randomised, controlled, double-blind, superiority, two-arm trial of 1222 high-risk patients aged 50 years or older undergoing major non-cardiac surgery at 32 acute care hospital in France. Patients are randomly assigned to dexamethasone (0.2 mg/kg at the end of the surgical procedure and at day +1, n=611) or to placebo (n=611). The primary outcome is a composite of predefined 14-day major pulmonary complications and mortality. Secondary outcomes are surgical complications, infections, organ failures, critical care-free days, length of hospital stay and all-cause mortality at 28 days.Ethics and disseminationThe PACMAN trial protocol has been approved by the ethics committee of Sud Mediterranée V, and will be carried out according to the Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The PACMAN trial is a randomised controlled trial powered to investigate whether perioperative administration of corticosteroids in patients undergoing non-cardiac major surgery reduces postoperative complications. The results of this study will be disseminated through presentation at scientific conferences and publication in peer-reviewed journals.Trial registration numberNCT03218553; Pre-results.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2017-021262</identifier><identifier>PMID: 30904834</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject><![CDATA[Abdomen ; Anaesthesia ; Bacterial infections ; Bacteriology ; Cardiology and cardiovascular system ; Clinical practice guidelines ; Clinical Protocols ; Critical Care - statistics & numerical data ; Dexamethasone - administration & dosage ; Double-blind studies ; Drug dosages ; Emerging diseases ; Evidence-based medicine ; Failure ; Female ; Glucocorticoids - administration & dosage ; Hospitals ; Human health and pathology ; Humans ; Infectious diseases ; Inflammation - etiology ; Inflammation - prevention & control ; Infusions, Intravenous ; Intensive care ; Length of Stay - statistics & numerical data ; Life Sciences ; Male ; Microbiology and Parasitology ; Middle Aged ; Morbidity ; Mortality ; Parasitology ; Patients ; Perioperative care ; Perioperative Care - methods ; Pneumonia ; Postoperative Complications - mortality ; Postoperative Complications - prevention & control ; Respiratory Tract Diseases - etiology ; Respiratory Tract Diseases - prevention & control ; Risk Adjustment - methods ; Steroids ; Surgical Procedures, Operative - adverse effects ; Systematic review ; Trauma ; Ventilators ; Virology ; Wound healing]]></subject><ispartof>BMJ open, 2019-03, Vol.9 (3), p.e021262-e021262</ispartof><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2019 Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><rights>Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b506t-2e20db3a90c09b7e13d3130fa9b473687c50ebfbdc666306d180630e4308ae883</citedby><cites>FETCH-LOGICAL-b506t-2e20db3a90c09b7e13d3130fa9b473687c50ebfbdc666306d180630e4308ae883</cites><orcidid>0000-0002-6454-271X ; 0000-0002-2870-6115 ; 0000-0003-1899-3517 ; 0000-0002-5478-482X ; 0000-0002-4424-4280 ; 0000-0001-6073-4354 ; 0000-0001-5804-5269 ; 0000-0002-6938-0967 ; 0000-0002-7257-8069 ; 0000-0002-1029-6242</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/9/3/e021262.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/9/3/e021262.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27526,27527,27901,27902,53766,53768,77343,77374</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30904834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-02509468$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Asehnoune, Karim</creatorcontrib><creatorcontrib>Futier, Emmanuel</creatorcontrib><creatorcontrib>Feuillet, Fanny</creatorcontrib><creatorcontrib>Roquilly, Antoine</creatorcontrib><creatorcontrib>PACMAN group</creatorcontrib><title>PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>IntroductionPostoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery. An excessive postoperative inflammatory response participates to the development of postoperative infection and mortality. The aim of the Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac surgery (PACMAN) study is to assess the effectiveness of perioperative administration of corticosteroid to reduce postoperative morbidity and mortality in patients undergoing major non-cardiac surgery.Methods and analysisThe PACMAN is a multicentre, randomised, controlled, double-blind, superiority, two-arm trial of 1222 high-risk patients aged 50 years or older undergoing major non-cardiac surgery at 32 acute care hospital in France. Patients are randomly assigned to dexamethasone (0.2 mg/kg at the end of the surgical procedure and at day +1, n=611) or to placebo (n=611). The primary outcome is a composite of predefined 14-day major pulmonary complications and mortality. Secondary outcomes are surgical complications, infections, organ failures, critical care-free days, length of hospital stay and all-cause mortality at 28 days.Ethics and disseminationThe PACMAN trial protocol has been approved by the ethics committee of Sud Mediterranée V, and will be carried out according to the Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The PACMAN trial is a randomised controlled trial powered to investigate whether perioperative administration of corticosteroids in patients undergoing non-cardiac major surgery reduces postoperative complications. The results of this study will be disseminated through presentation at scientific conferences and publication in peer-reviewed journals.Trial registration numberNCT03218553; Pre-results.</description><subject>Abdomen</subject><subject>Anaesthesia</subject><subject>Bacterial infections</subject><subject>Bacteriology</subject><subject>Cardiology and cardiovascular system</subject><subject>Clinical practice guidelines</subject><subject>Clinical Protocols</subject><subject>Critical Care - statistics & numerical data</subject><subject>Dexamethasone - administration & dosage</subject><subject>Double-blind studies</subject><subject>Drug dosages</subject><subject>Emerging diseases</subject><subject>Evidence-based medicine</subject><subject>Failure</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Hospitals</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation - etiology</subject><subject>Inflammation - prevention & control</subject><subject>Infusions, Intravenous</subject><subject>Intensive care</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Parasitology</subject><subject>Patients</subject><subject>Perioperative care</subject><subject>Perioperative Care - methods</subject><subject>Pneumonia</subject><subject>Postoperative Complications - mortality</subject><subject>Postoperative Complications - prevention & control</subject><subject>Respiratory Tract Diseases - etiology</subject><subject>Respiratory Tract Diseases - prevention & control</subject><subject>Risk Adjustment - methods</subject><subject>Steroids</subject><subject>Surgical Procedures, Operative - adverse effects</subject><subject>Systematic review</subject><subject>Trauma</subject><subject>Ventilators</subject><subject>Virology</subject><subject>Wound healing</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNks1u1DAUhSMEolXpEyAhS2xAmpTrnzgJi0rRCChSW7qAtWXHTsejJA62M9K8Gw-HwwxV6Qpv_HO_c3xtnSx7jeECY8o_qGHrJjPmBHCZA8GEk2fZKQHGcg5F8fzR-iQ7D2ELabCiLgryMjuhUAOrKDvNft0165vmFkVvZY8m76JrXb9Cd8bbdIGX0e4MavRgRxvisnUjch1aOx9t6-ImIdMepcMb55XVNu6RHDUaUl32y67povHo1o15K722skWD3DqPwuzvjd9_RBL5pHCDDUav0DD3ydiM0ZsV0m5WvclVb8dUCvO0dOUX1xBnvX-VvehkH8z5cT7Lfnz-9H19lV9_-_J13VznqgAec2IIaEVlDS3UqjSYaoopdLJWrKS8KtsCjOqUbjnnFLjGFaTZMAqVNFVFz7LLg-80q8HoP93JXkzeDtLvhZNW_FsZ7Ubcu53grCwILpLB-4PB5onsqrkWyxmQAmrGqx1O7LvjZd79nE2IIv1Ma_pejsbNQRBcl5RUFLOEvn2Cbt3sx_QVC8UxA4p5ouiBar0LwZvuoQMMYgmTOIZJLGEShzAl1ZvHb37Q_I1OAi4OQFL_l-NvjpnZPQ</recordid><startdate>20190323</startdate><enddate>20190323</enddate><creator>Asehnoune, Karim</creator><creator>Futier, Emmanuel</creator><creator>Feuillet, Fanny</creator><creator>Roquilly, Antoine</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6454-271X</orcidid><orcidid>https://orcid.org/0000-0002-2870-6115</orcidid><orcidid>https://orcid.org/0000-0003-1899-3517</orcidid><orcidid>https://orcid.org/0000-0002-5478-482X</orcidid><orcidid>https://orcid.org/0000-0002-4424-4280</orcidid><orcidid>https://orcid.org/0000-0001-6073-4354</orcidid><orcidid>https://orcid.org/0000-0001-5804-5269</orcidid><orcidid>https://orcid.org/0000-0002-6938-0967</orcidid><orcidid>https://orcid.org/0000-0002-7257-8069</orcidid><orcidid>https://orcid.org/0000-0002-1029-6242</orcidid></search><sort><creationdate>20190323</creationdate><title>PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study</title><author>Asehnoune, Karim ; Futier, Emmanuel ; Feuillet, Fanny ; Roquilly, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b506t-2e20db3a90c09b7e13d3130fa9b473687c50ebfbdc666306d180630e4308ae883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abdomen</topic><topic>Anaesthesia</topic><topic>Bacterial infections</topic><topic>Bacteriology</topic><topic>Cardiology and cardiovascular system</topic><topic>Clinical practice guidelines</topic><topic>Clinical Protocols</topic><topic>Critical Care - statistics & numerical data</topic><topic>Dexamethasone - administration & dosage</topic><topic>Double-blind studies</topic><topic>Drug dosages</topic><topic>Emerging diseases</topic><topic>Evidence-based medicine</topic><topic>Failure</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Hospitals</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation - etiology</topic><topic>Inflammation - prevention & control</topic><topic>Infusions, Intravenous</topic><topic>Intensive care</topic><topic>Length of Stay - statistics & numerical data</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Microbiology and Parasitology</topic><topic>Middle Aged</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Parasitology</topic><topic>Patients</topic><topic>Perioperative care</topic><topic>Perioperative Care - methods</topic><topic>Pneumonia</topic><topic>Postoperative Complications - mortality</topic><topic>Postoperative Complications - prevention & control</topic><topic>Respiratory Tract Diseases - etiology</topic><topic>Respiratory Tract Diseases - prevention & control</topic><topic>Risk Adjustment - methods</topic><topic>Steroids</topic><topic>Surgical Procedures, Operative - adverse effects</topic><topic>Systematic review</topic><topic>Trauma</topic><topic>Ventilators</topic><topic>Virology</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asehnoune, Karim</creatorcontrib><creatorcontrib>Futier, Emmanuel</creatorcontrib><creatorcontrib>Feuillet, Fanny</creatorcontrib><creatorcontrib>Roquilly, Antoine</creatorcontrib><creatorcontrib>PACMAN group</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asehnoune, Karim</au><au>Futier, Emmanuel</au><au>Feuillet, Fanny</au><au>Roquilly, Antoine</au><aucorp>PACMAN group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2019-03-23</date><risdate>2019</risdate><volume>9</volume><issue>3</issue><spage>e021262</spage><epage>e021262</epage><pages>e021262-e021262</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>IntroductionPostoperative complications are major healthcare problems and are associated with a reduced short-term and long-term survival after surgery. An excessive postoperative inflammatory response participates to the development of postoperative infection and mortality. The aim of the Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac surgery (PACMAN) study is to assess the effectiveness of perioperative administration of corticosteroid to reduce postoperative morbidity and mortality in patients undergoing major non-cardiac surgery.Methods and analysisThe PACMAN is a multicentre, randomised, controlled, double-blind, superiority, two-arm trial of 1222 high-risk patients aged 50 years or older undergoing major non-cardiac surgery at 32 acute care hospital in France. Patients are randomly assigned to dexamethasone (0.2 mg/kg at the end of the surgical procedure and at day +1, n=611) or to placebo (n=611). The primary outcome is a composite of predefined 14-day major pulmonary complications and mortality. Secondary outcomes are surgical complications, infections, organ failures, critical care-free days, length of hospital stay and all-cause mortality at 28 days.Ethics and disseminationThe PACMAN trial protocol has been approved by the ethics committee of Sud Mediterranée V, and will be carried out according to the Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The PACMAN trial is a randomised controlled trial powered to investigate whether perioperative administration of corticosteroids in patients undergoing non-cardiac major surgery reduces postoperative complications. The results of this study will be disseminated through presentation at scientific conferences and publication in peer-reviewed journals.Trial registration numberNCT03218553; Pre-results.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30904834</pmid><doi>10.1136/bmjopen-2017-021262</doi><orcidid>https://orcid.org/0000-0002-6454-271X</orcidid><orcidid>https://orcid.org/0000-0002-2870-6115</orcidid><orcidid>https://orcid.org/0000-0003-1899-3517</orcidid><orcidid>https://orcid.org/0000-0002-5478-482X</orcidid><orcidid>https://orcid.org/0000-0002-4424-4280</orcidid><orcidid>https://orcid.org/0000-0001-6073-4354</orcidid><orcidid>https://orcid.org/0000-0001-5804-5269</orcidid><orcidid>https://orcid.org/0000-0002-6938-0967</orcidid><orcidid>https://orcid.org/0000-0002-7257-8069</orcidid><orcidid>https://orcid.org/0000-0002-1029-6242</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abdomen Anaesthesia Bacterial infections Bacteriology Cardiology and cardiovascular system Clinical practice guidelines Clinical Protocols Critical Care - statistics & numerical data Dexamethasone - administration & dosage Double-blind studies Drug dosages Emerging diseases Evidence-based medicine Failure Female Glucocorticoids - administration & dosage Hospitals Human health and pathology Humans Infectious diseases Inflammation - etiology Inflammation - prevention & control Infusions, Intravenous Intensive care Length of Stay - statistics & numerical data Life Sciences Male Microbiology and Parasitology Middle Aged Morbidity Mortality Parasitology Patients Perioperative care Perioperative Care - methods Pneumonia Postoperative Complications - mortality Postoperative Complications - prevention & control Respiratory Tract Diseases - etiology Respiratory Tract Diseases - prevention & control Risk Adjustment - methods Steroids Surgical Procedures, Operative - adverse effects Systematic review Trauma Ventilators Virology Wound healing |
| title | PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T02%3A01%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PACMAN%20trial%20protocol,%20Perioperative%20Administration%20of%20Corticotherapy%20on%20Morbidity%20and%20mortality%20After%20Non-cardiac%20major%20surgery:%20a%20randomised,%20multicentre,%20double-blind,%20superiority%20study&rft.jtitle=BMJ%20open&rft.au=Asehnoune,%20Karim&rft.aucorp=PACMAN%20group&rft.date=2019-03-23&rft.volume=9&rft.issue=3&rft.spage=e021262&rft.epage=e021262&rft.pages=e021262-e021262&rft.issn=2044-6055&rft.eissn=2044-6055&rft_id=info:doi/10.1136/bmjopen-2017-021262&rft_dat=%3Cproquest_pubme%3E2196140316%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2196140316&rft_id=info:pmid/30904834&rfr_iscdi=true |