A genome-scale CRISPR-Cas9 screening in myeloma cells identifies regulators of immunomodulatory drug sensitivity

Immunomodulatory drugs (IMiDs) including lenalidomide and pomalidomide bind cereblon (CRBN) and activate the CRL4 CRBN ubiquitin ligase to trigger proteasomal degradation of the essential transcription factors IKZF1 and IKZF3 and multiple myeloma (MM) cytotoxicity. We have shown that CRBN is also ta...

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Veröffentlicht in:	Leukemia 2019-01, Vol.33 (1), p.171-180
Hauptverfasser:	Liu, Jiye, Song, Tianyu, Zhou, Wenrong, Xing, Lijie, Wang, Su, Ho, Matthew, Peng, Zhengang, Tai, Yu-Tzu, Hideshima, Teru, Anderson, Kenneth C., Cang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	42/109 45/41 45/43 631/67/1059/2326 631/67/1990/804 82/1 96/2 96/47 96/95 Adaptor Proteins, Signal Transducing Antineoplastic Agents - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Bortezomib - pharmacology Cancer cells Cancer genetics Cancer Research COP9 Signalosome Complex - antagonists & inhibitors COP9 Signalosome Complex - genetics COP9 Signalosome Complex - metabolism CRISPR CRISPR-Cas Systems Critical Care Medicine Cullin Cyclopentanes - pharmacology Cytotoxicity Deactivation Degradation DNA binding proteins Drug resistance Drugs Enzyme Inhibitors - pharmacology Enzymes Gene expression Gene Expression Regulation, Neoplastic Genomes Genomics Hematology Humans Ikaros Transcription Factor - genetics Ikaros Transcription Factor - metabolism Immunologic factors Immunologic Factors - pharmacology Immunomodulation Immunomodulators Inhibitors Intensive Internal Medicine Lenalidomide Ligases Medical screening Medicine Medicine & Public Health Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - genetics Multiple Myeloma - pathology Oncology Peptide Hydrolases - genetics Peptide Hydrolases - metabolism Prognosis Proteasome inhibitors Proteasomes Proteolysis Pyrimidines - pharmacology Regulators Sensitivity Sensitivity enhancement Toxicity Transcription factors Tumor Cells, Cultured Ubiquitin Ubiquitin-protein ligase Ubiquitin-Protein Ligases Ubiquitination
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