Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure
The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. C tenomys torquatus are...
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| Veröffentlicht in: | Scientific reports 2019-04, Vol.9 (1), p.6325, Article 6325 |
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| creator | Matzenbacher, Cristina A. Da Silva, Juliana Garcia, Ana Leticia H. Cappetta, Mónica de Freitas, Thales R. O. |
| description | The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. C
tenomys torquatus
are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Exposure to pollutants can cause DNA damage and affect different tissues, inducing alterations in the population structure and genetic diversity. Our study aimed to evaluate the effect of exposure to coal and its derivatives on the
C. torquatus
population and to examine the relationship of coal exposure with variations in absolute telomere length (aTL), global DNA methylation and genotoxicity. Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. The results indicate that coal and its byproducts can contribute to the alteration of the
C. torquatus
population structure, as evidenced by a reduction in the number of adults. |
| doi_str_mv | 10.1038/s41598-019-42804-8 |
| format | Article |
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tenomys torquatus
are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Exposure to pollutants can cause DNA damage and affect different tissues, inducing alterations in the population structure and genetic diversity. Our study aimed to evaluate the effect of exposure to coal and its derivatives on the
C. torquatus
population and to examine the relationship of coal exposure with variations in absolute telomere length (aTL), global DNA methylation and genotoxicity. Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. The results indicate that coal and its byproducts can contribute to the alteration of the
C. torquatus
population structure, as evidenced by a reduction in the number of adults.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-42804-8</identifier><identifier>PMID: 31004106</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/29 ; 45/70 ; 45/77 ; 631/158/672 ; 631/208/176/1988 ; 704/172/4081 ; Animals ; Anthropogenic factors ; Coal ; Coal - adverse effects ; Coal mines ; Coal Mining ; Deoxyribonucleic acid ; DNA ; DNA damage ; DNA Damage - drug effects ; DNA methylation ; Environmental impact ; Exposure ; Food contamination ; Fossil fuels ; Genetic diversity ; Genotoxicity ; Heavy metals ; Humanities and Social Sciences ; Humans ; multidisciplinary ; Pollutants ; Polycyclic aromatic hydrocarbons ; Population Dynamics ; Population genetics ; Population structure ; Rodentia - genetics ; Rodentia - metabolism ; Science ; Science (multidisciplinary) ; Telomere Homeostasis - drug effects ; Tunnels</subject><ispartof>Scientific reports, 2019-04, Vol.9 (1), p.6325, Article 6325</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-df7e9e82453c8c31b63c09a0e5be72d38030643e63c62064b23affa5aa5f22443</citedby><cites>FETCH-LOGICAL-c513t-df7e9e82453c8c31b63c09a0e5be72d38030643e63c62064b23affa5aa5f22443</cites><orcidid>0000-0001-7022-2483 ; 0000-0002-1089-6766 ; 0000-0003-2015-0156</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474877/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474877/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,41125,42194,51581,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31004106$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matzenbacher, Cristina A.</creatorcontrib><creatorcontrib>Da Silva, Juliana</creatorcontrib><creatorcontrib>Garcia, Ana Leticia H.</creatorcontrib><creatorcontrib>Cappetta, Mónica</creatorcontrib><creatorcontrib>de Freitas, Thales R. O.</creatorcontrib><title>Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. C
tenomys torquatus
are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Exposure to pollutants can cause DNA damage and affect different tissues, inducing alterations in the population structure and genetic diversity. Our study aimed to evaluate the effect of exposure to coal and its derivatives on the
C. torquatus
population and to examine the relationship of coal exposure with variations in absolute telomere length (aTL), global DNA methylation and genotoxicity. Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. The results indicate that coal and its byproducts can contribute to the alteration of the
C. torquatus
population structure, as evidenced by a reduction in the number of adults.</description><subject>45/29</subject><subject>45/70</subject><subject>45/77</subject><subject>631/158/672</subject><subject>631/208/176/1988</subject><subject>704/172/4081</subject><subject>Animals</subject><subject>Anthropogenic factors</subject><subject>Coal</subject><subject>Coal - adverse effects</subject><subject>Coal mines</subject><subject>Coal Mining</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA methylation</subject><subject>Environmental impact</subject><subject>Exposure</subject><subject>Food contamination</subject><subject>Fossil fuels</subject><subject>Genetic diversity</subject><subject>Genotoxicity</subject><subject>Heavy metals</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>multidisciplinary</subject><subject>Pollutants</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Population Dynamics</subject><subject>Population genetics</subject><subject>Population structure</subject><subject>Rodentia - genetics</subject><subject>Rodentia - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Telomere Homeostasis - drug effects</subject><subject>Tunnels</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kctu2zAQRYmiQW2k_oEuCgJZK-VTorII4BhuWsB5LJw1QcsjW4FEKiTVpn8fNkqdZFNuOMO5c2eIg9AXSk4p4epbEFSWKiO0zARTRGTqA5oyImTGOGMf38QTNAvhnqQjWSlo-QlNOCVEUJJPUTe3ce9d73Zgmwov6xqqGLCz-NrEwZsWX5muM21jLL51_dCa2DgbzvDCeQ9jhi8g_gaweA2t68ADXoHdxT02dpt0yWP52LswePiMjmrTBpi93Mfo7vtyvfiRrW4ufy7mq6ySlMdsWxdQgmJC8kpVnG5yXpHSEJAbKNiWK8JJLjik55ylaMO4qWsjjZE1Y0LwY3Q--vbDpoNtBTamr-jeN53xf7QzjX5fsc1e79wvnYtCqKJIBicvBt49DBCivneDt2lnzRilUqpc8aRio6ryLgQP9WECJfovJT1S0omSfqakVWr6-na3Q8s_JknAR0FIJbsD_zr7P7ZPzGOe6w</recordid><startdate>20190419</startdate><enddate>20190419</enddate><creator>Matzenbacher, Cristina A.</creator><creator>Da Silva, Juliana</creator><creator>Garcia, Ana Leticia H.</creator><creator>Cappetta, Mónica</creator><creator>de Freitas, Thales R. 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O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-04-19</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>6325</spage><pages>6325-</pages><artnum>6325</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The Candiota coal mine in Rio Grande do Sul (RS) is one of the largest in Brazil. Coal is a fossil fuel that causes environmental impacts from its extraction to combustion due to the release of different agents, such as polycyclic aromatic hydrocarbons (PAH) and heavy metals. C
tenomys torquatus
are herbivorous and subterranean rodents that dig tunnels with their paws and teeth and can be exposed to coal through contaminated food. Exposure to pollutants can cause DNA damage and affect different tissues, inducing alterations in the population structure and genetic diversity. Our study aimed to evaluate the effect of exposure to coal and its derivatives on the
C. torquatus
population and to examine the relationship of coal exposure with variations in absolute telomere length (aTL), global DNA methylation and genotoxicity. Our study showed an inverse correlation between telomere length and coal exposure in addition to an increase in DNA damage. The results indicate that coal and its byproducts can contribute to the alteration of the
C. torquatus
population structure, as evidenced by a reduction in the number of adults.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31004106</pmid><doi>10.1038/s41598-019-42804-8</doi><orcidid>https://orcid.org/0000-0001-7022-2483</orcidid><orcidid>https://orcid.org/0000-0002-1089-6766</orcidid><orcidid>https://orcid.org/0000-0003-2015-0156</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 45/29 45/70 45/77 631/158/672 631/208/176/1988 704/172/4081 Animals Anthropogenic factors Coal Coal - adverse effects Coal mines Coal Mining Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA methylation Environmental impact Exposure Food contamination Fossil fuels Genetic diversity Genotoxicity Heavy metals Humanities and Social Sciences Humans multidisciplinary Pollutants Polycyclic aromatic hydrocarbons Population Dynamics Population genetics Population structure Rodentia - genetics Rodentia - metabolism Science Science (multidisciplinary) Telomere Homeostasis - drug effects Tunnels |
| title | Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure |
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