Revisiting immune escape in colorectal cancer in the era of immunotherapy

In colorectal cancer (CRC), T-cell checkpoint blockade is only effective in patients diagnosed with mismatch repair-deficient (MMR-d) cancers. However, defects in Human Leukocyte Antigen (HLA) class I expression were reported to occur in most MMR-d CRCs, which would preclude antigen presentation in...

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Veröffentlicht in:	British journal of cancer 2019-04, Vol.120 (8), p.815-818
Hauptverfasser:	Ijsselsteijn, Marieke Erica, Petitprez, Florent, Lacroix, Laetitia, Ruano, Dina, van der Breggen, Ruud, Julie, Catherine, Morreau, Hans, Sautès-Fridman, Catherine, Fridman, Wolf Herman, de Miranda, Noel Filipe da Cunha Carvalho
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2161 692/4028/67/1504/1885 692/4028/67/322 692/4028/67/580/1884/2323 692/420/755 Antigen presentation Antigen Presentation - immunology Antigenic determinants Antigens Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - immunology Brief Communication Cancer Cancer Research Carcinogenesis Carcinogenesis - genetics Carcinogenesis - immunology Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Colorectal Neoplasms - therapy Drug Resistance Epidemiology Female Gene Expression Regulation, Neoplastic - immunology Genes, cdc - drug effects Genes, cdc - immunology Genes, MHC Class I - genetics Homing Human health and pathology Humans Hépatology and Gastroenterology Immune checkpoint Immune evasion Immunology Immunotherapy Lesions Life Sciences Liver Liver - metabolism Liver - pathology Lymphocytes T Male Metastases Metastasis Middle Aged Mismatch repair Molecular Medicine Neoplasm Metastasis Neoplastic Syndromes, Hereditary - genetics Neoplastic Syndromes, Hereditary - immunology Oncology Phenotypes T-Lymphocytes - immunology Tumors
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