Role of Arginase 2 in Systemic Metabolic Activity and Adipose Tissue Fatty Acid Metabolism in Diet-Induced Obese Mice

Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in pathologies associated with obesity and diabetes. This...

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Veröffentlicht in:	International journal of molecular sciences 2019-03, Vol.20 (6), p.1462
Hauptverfasser:	Atawia, Reem T, Toque, Haroldo A, Meghil, Mohamed M, Benson, Tyler W, Yiew, Nicole K H, Cutler, Christopher W, Weintraub, Neal L, Caldwell, Ruth B, Caldwell, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipose tissue Adipose Tissue - metabolism Adipose Tissue - pathology Animals Arginase Arginase - genetics Arginase - metabolism Biomarkers Body fat Body weight Chemokines Diet, High-Fat - adverse effects Disease Models, Animal Energy expenditure Energy Metabolism Fatty Acids - metabolism Fibrosis Gene Deletion Gene expression High fat diet Hypertrophy Hypoxia-inducible factors Inflammation Insulin resistance Kinases Macrophages Mice Mitochondria Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes NMR Nuclear magnetic resonance Obesity Obesity - etiology Obesity - metabolism Obesity - pathology Oxidation Oxidation-Reduction Oxidative Stress Oxygen Consumption Polymerase chain reaction Rodents Sucrose Sucrose - metabolism Tumor necrosis factor-α
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