Specificity of the Metallothionein-1 Response by Cadmium-Exposed Normal Human Urothelial Cells

Occupational and environmental exposure to cadmium is associated with the development of urothelial cancer. The metallothionein (MT) family of genes encodes proteins that sequester metal ions and modulate physiological processes, including zinc homeostasis. Little is known about the selectivity of e...

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Veröffentlicht in:	International journal of molecular sciences 2019-03, Vol.20 (6), p.1344
Hauptverfasser:	McNeill, Rhiannon V, Mason, Andrew S, Hodson, Mark E, Catto, James W F, Southgate, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Bladder Bladder cancer Burning Cadmium Cadmium - metabolism Cation Transport Proteins - genetics Cell culture Cell growth Cell Proliferation Cells, Cultured Cytotoxicity Efflux Electroplating Emission analysis Environmental Pollutants - metabolism Exposure Gene expression Homeostasis Humans Inductively coupled plasma Ion concentration Lysates Metallothionein Metallothionein - genetics Occupational exposure Optical emission spectroscopy Protein Isoforms - genetics Proteins Smelting Soldering Spectroscopy Transcription Transcriptional Activation Urine Urothelium - cytology Urothelium - metabolism Zinc Zinc transporter
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