UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries
Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, n...
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| Veröffentlicht in: | International journal of molecular sciences 2019-03, Vol.20 (6), p.1376 |
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| creator | Lorigo, Margarida Quintaneiro, Carla Lemos, Manuel C. Martinez-de-Oliveira, José Breitenfeld, Luiza Cairrao, Elisa |
| description | Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC). |
| doi_str_mv | 10.3390/ijms20061376 |
| format | Article |
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Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20061376</identifier><identifier>PMID: 30893788</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Arteries ; Calcium ; Calcium ions ; Cardiovascular diseases ; Children ; Computational fluid dynamics ; Contractility ; Corals ; Depolarization ; Embryos ; Endocrine disruptors ; Endocrine system ; Experiments ; Fetuses ; Gestation ; Guanylate cyclase ; Histamine ; Infants ; Joint use ; Potassium chloride ; Pregnancy ; Sensitivity analysis ; Serotonin ; Toxicity ; Vasodilation ; Veins & arteries ; Zebrafish</subject><ispartof>International journal of molecular sciences, 2019-03, Vol.20 (6), p.1376</ispartof><rights>2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). 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Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>30893788</pmid><doi>10.3390/ijms20061376</doi><orcidid>https://orcid.org/0000-0001-9326-8900</orcidid><orcidid>https://orcid.org/0000-0002-1151-8177</orcidid><orcidid>https://orcid.org/0000-0002-4823-5701</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arteries Calcium Calcium ions Cardiovascular diseases Children Computational fluid dynamics Contractility Corals Depolarization Embryos Endocrine disruptors Endocrine system Experiments Fetuses Gestation Guanylate cyclase Histamine Infants Joint use Potassium chloride Pregnancy Sensitivity analysis Serotonin Toxicity Vasodilation Veins & arteries Zebrafish |
| title | UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
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