Synthesis of New GABAA Receptor Modulator with Pyrazolo[1,5-a]quinazoline (PQ) Scaffold

We previously published a series of 8-methoxypirazolo[1,5-a]quinazolines (PQs) and their 4,5-dihydro derivatives (4,5(H)PQ) bearing the (hetero)arylalkylester group at position 3 as ligands at the γ-aminobutyric type A (GABAA) subtype receptor. Continuing the study in this field, we report here the...

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Veröffentlicht in:	International journal of molecular sciences 2019-03, Vol.20 (6), p.1438
Hauptverfasser:	Guerrini, Gabriella, Vergelli, Claudia, Cantini, Niccolò, Giovannoni, Maria Paola, Daniele, Simona, Mascia, Maria Paola, Martini, Claudia, Crocetti, Letizia
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Benzodiazepines Binding sites Chlorine Diazepam Flumazenil Gametocytes Interfaces Ligands Oocytes Proteins γ-Aminobutyric acid A receptors
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