Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey

Serotonin is a neurotransmitter involved in various physiological processes in the central and peripheral nervous systems. Serotonin is also a precursor for melatonin biosynthesis, which mainly occurs in the pineal gland of vertebrates. Tryptophan hydroxylase (TPH) acts as the rate-limiting enzyme i...

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Veröffentlicht in:	Genes 2019-03, Vol.10 (3), p.203
Hauptverfasser:	Xu, Junmin, Li, Yanping, Lv, Yunyun, Bian, Chao, You, Xinxin, Endoh, Daiji, Teraoka, Hiroki, Shi, Qiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Animals Biosynthesis Chickens Divergence Endocrine system Enzymatic activity Enzymes Evolution Evolution, Molecular Evolutionary genetics Genes Genomes Genomics Humans Isotypes Mammals Melatonin Migraine Molecular evolution Nervous system Phylogenetics Phylogeny Pineal gland Protein Conformation Proteins Selection, Genetic Serotonin Substrate specificity Tryptophan Tryptophan hydroxylase Tryptophan Hydroxylase - chemistry Tryptophan Hydroxylase - genetics Turtles Vertebrates Xenopus Zebrafish
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