Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans
Few studies have assessed prescription opioid supply preceding death in individuals dying from unintentional prescription opioid overdoses, or described the characteristics of these individuals, particularly among Veterans. To describe the history of prescription opioid supply preceding prescription...
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| Veröffentlicht in: | Research in social and administrative pharmacy 2019-08, Vol.15 (8), p.1007-1013 |
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| creator | Moyo, Patience Zhao, Xinhua Thorpe, Carolyn T. Thorpe, Joshua M. Sileanu, Florentina E. Cashy, John P. Hale, Jennifer A. Mor, Maria K. Radomski, Thomas R. Donohue, Julie M. Hausmann, Leslie R.M. Hanlon, Joseph T. Good, Chester B. Fine, Michael J. Gellad, Walid F. |
| description | Few studies have assessed prescription opioid supply preceding death in individuals dying from unintentional prescription opioid overdoses, or described the characteristics of these individuals, particularly among Veterans.
To describe the history of prescription opioid supply preceding prescription opioid overdose death among Veterans.
In a national cohort of Veterans who filled ≥1 opioid prescriptions from the Veterans Health Administration (VA) or Medicare Part D during 2008–2013, we identified deaths from unintentional or undetermined-intent prescription opioid overdoses in 2012–2013. We captured opioid prescriptions using both linked VA and Part D data, and VA data only.
Among 1181 decedents, 643 (54.4%) had prescription opioid supply on the day of death, and 735 (62.2%) within 30 days based on linked data, compared to 40.1% and 46.7%, respectively, using VA data alone. Decedents with prescription opioid supply were significantly older and less likely to have alcohol or illicit drugs as co-occurring substances involved in the overdose. Using linked data, 241 (20.4%) decedents lacked prescription opioid supply within a year of death.
Many VA patients who die from prescription opioid overdose receive opioid prescriptions outside VA or not at all. It is important to supplement VA with non-VA data to more accurately measure prescription opioid exposure and improve opioid medication safety. |
| doi_str_mv | 10.1016/j.sapharm.2018.10.023 |
| format | Article |
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To describe the history of prescription opioid supply preceding prescription opioid overdose death among Veterans.
In a national cohort of Veterans who filled ≥1 opioid prescriptions from the Veterans Health Administration (VA) or Medicare Part D during 2008–2013, we identified deaths from unintentional or undetermined-intent prescription opioid overdoses in 2012–2013. We captured opioid prescriptions using both linked VA and Part D data, and VA data only.
Among 1181 decedents, 643 (54.4%) had prescription opioid supply on the day of death, and 735 (62.2%) within 30 days based on linked data, compared to 40.1% and 46.7%, respectively, using VA data alone. Decedents with prescription opioid supply were significantly older and less likely to have alcohol or illicit drugs as co-occurring substances involved in the overdose. Using linked data, 241 (20.4%) decedents lacked prescription opioid supply within a year of death.
Many VA patients who die from prescription opioid overdose receive opioid prescriptions outside VA or not at all. It is important to supplement VA with non-VA data to more accurately measure prescription opioid exposure and improve opioid medication safety.</description><identifier>ISSN: 1551-7411</identifier><identifier>EISSN: 1934-8150</identifier><identifier>DOI: 10.1016/j.sapharm.2018.10.023</identifier><identifier>PMID: 30385111</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Analgesics, Opioid - adverse effects ; Drug overdose ; Drug Overdose - mortality ; Drug Prescriptions - statistics & numerical data ; Female ; Humans ; Male ; Medicare Part D ; Middle Aged ; Poisoning deaths ; Prescription opioids ; United States ; United States Department of Veterans Affairs - statistics & numerical data ; Veterans ; Veterans - statistics & numerical data ; Young Adult</subject><ispartof>Research in social and administrative pharmacy, 2019-08, Vol.15 (8), p.1007-1013</ispartof><rights>2018</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-c9f890ae0034f6f0e5262fbb49f3c98aa8daad1689f5d14b07969c63d8bf4a243</citedby><cites>FETCH-LOGICAL-c467t-c9f890ae0034f6f0e5262fbb49f3c98aa8daad1689f5d14b07969c63d8bf4a243</cites><orcidid>0000-0002-5871-0000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1551741118302821$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30385111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moyo, Patience</creatorcontrib><creatorcontrib>Zhao, Xinhua</creatorcontrib><creatorcontrib>Thorpe, Carolyn T.</creatorcontrib><creatorcontrib>Thorpe, Joshua M.</creatorcontrib><creatorcontrib>Sileanu, Florentina E.</creatorcontrib><creatorcontrib>Cashy, John P.</creatorcontrib><creatorcontrib>Hale, Jennifer A.</creatorcontrib><creatorcontrib>Mor, Maria K.</creatorcontrib><creatorcontrib>Radomski, Thomas R.</creatorcontrib><creatorcontrib>Donohue, Julie M.</creatorcontrib><creatorcontrib>Hausmann, Leslie R.M.</creatorcontrib><creatorcontrib>Hanlon, Joseph T.</creatorcontrib><creatorcontrib>Good, Chester B.</creatorcontrib><creatorcontrib>Fine, Michael J.</creatorcontrib><creatorcontrib>Gellad, Walid F.</creatorcontrib><title>Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans</title><title>Research in social and administrative pharmacy</title><addtitle>Res Social Adm Pharm</addtitle><description>Few studies have assessed prescription opioid supply preceding death in individuals dying from unintentional prescription opioid overdoses, or described the characteristics of these individuals, particularly among Veterans.
To describe the history of prescription opioid supply preceding prescription opioid overdose death among Veterans.
In a national cohort of Veterans who filled ≥1 opioid prescriptions from the Veterans Health Administration (VA) or Medicare Part D during 2008–2013, we identified deaths from unintentional or undetermined-intent prescription opioid overdoses in 2012–2013. We captured opioid prescriptions using both linked VA and Part D data, and VA data only.
Among 1181 decedents, 643 (54.4%) had prescription opioid supply on the day of death, and 735 (62.2%) within 30 days based on linked data, compared to 40.1% and 46.7%, respectively, using VA data alone. Decedents with prescription opioid supply were significantly older and less likely to have alcohol or illicit drugs as co-occurring substances involved in the overdose. Using linked data, 241 (20.4%) decedents lacked prescription opioid supply within a year of death.
Many VA patients who die from prescription opioid overdose receive opioid prescriptions outside VA or not at all. It is important to supplement VA with non-VA data to more accurately measure prescription opioid exposure and improve opioid medication safety.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Drug overdose</subject><subject>Drug Overdose - mortality</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicare Part D</subject><subject>Middle Aged</subject><subject>Poisoning deaths</subject><subject>Prescription opioids</subject><subject>United States</subject><subject>United States Department of Veterans Affairs - statistics & numerical data</subject><subject>Veterans</subject><subject>Veterans - statistics & numerical data</subject><subject>Young Adult</subject><issn>1551-7411</issn><issn>1934-8150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOwzAQtBCIR-ETQPmBFDtxHr6AUMVLqgQH4Gpt7HXrqo0jO63E3-OoD8GJk63Z2ZndHUKuGR0zysrbxThANwe_GmeU1REb0yw_IudM5DytWUGP478oWFpxxs7IRQgLSvOKMn5KznKa1wVj7Jz4d-h79G1InElcZ53VSecxKG-73rqIe1RoNzjA1vmkd8m6tW2P7VCG5R_2XsFt0GsXMNEI_TyBlWtnyRdGI2jDJTkxsAx4tXtH5PPp8WPykk7fnl8nD9NU8bLqUyVMLShgnJqb0lAssjIzTcOFyZWoAWoNoFlZC1NoxhtaiVKoMtd1YzhkPB-Ru61ut25WqFWc2MNSxjVW4L-lAyv_Vlo7lzO3kSWvoqmIAsVWQHkXgkdz6GVUDiHIhdyFIIcQBjiGEPtufhsfuvZXj4T7LQHj-huLXgZlsVWobbx2L7Wz_1j8ANOEoKw</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Moyo, Patience</creator><creator>Zhao, Xinhua</creator><creator>Thorpe, Carolyn T.</creator><creator>Thorpe, Joshua M.</creator><creator>Sileanu, Florentina E.</creator><creator>Cashy, John P.</creator><creator>Hale, Jennifer A.</creator><creator>Mor, Maria K.</creator><creator>Radomski, Thomas R.</creator><creator>Donohue, Julie M.</creator><creator>Hausmann, Leslie R.M.</creator><creator>Hanlon, Joseph T.</creator><creator>Good, Chester B.</creator><creator>Fine, Michael J.</creator><creator>Gellad, Walid F.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5871-0000</orcidid></search><sort><creationdate>20190801</creationdate><title>Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans</title><author>Moyo, Patience ; Zhao, Xinhua ; Thorpe, Carolyn T. ; Thorpe, Joshua M. ; Sileanu, Florentina E. ; Cashy, John P. ; Hale, Jennifer A. ; Mor, Maria K. ; Radomski, Thomas R. ; Donohue, Julie M. ; Hausmann, Leslie R.M. ; Hanlon, Joseph T. ; Good, Chester B. ; Fine, Michael J. ; Gellad, Walid F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-c9f890ae0034f6f0e5262fbb49f3c98aa8daad1689f5d14b07969c63d8bf4a243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Drug overdose</topic><topic>Drug Overdose - mortality</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicare Part D</topic><topic>Middle Aged</topic><topic>Poisoning deaths</topic><topic>Prescription opioids</topic><topic>United States</topic><topic>United States Department of Veterans Affairs - statistics & numerical data</topic><topic>Veterans</topic><topic>Veterans - statistics & numerical data</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moyo, Patience</creatorcontrib><creatorcontrib>Zhao, Xinhua</creatorcontrib><creatorcontrib>Thorpe, Carolyn T.</creatorcontrib><creatorcontrib>Thorpe, Joshua M.</creatorcontrib><creatorcontrib>Sileanu, Florentina E.</creatorcontrib><creatorcontrib>Cashy, John P.</creatorcontrib><creatorcontrib>Hale, Jennifer A.</creatorcontrib><creatorcontrib>Mor, Maria K.</creatorcontrib><creatorcontrib>Radomski, Thomas R.</creatorcontrib><creatorcontrib>Donohue, Julie M.</creatorcontrib><creatorcontrib>Hausmann, Leslie R.M.</creatorcontrib><creatorcontrib>Hanlon, Joseph T.</creatorcontrib><creatorcontrib>Good, Chester B.</creatorcontrib><creatorcontrib>Fine, Michael J.</creatorcontrib><creatorcontrib>Gellad, Walid F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Research in social and administrative pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moyo, Patience</au><au>Zhao, Xinhua</au><au>Thorpe, Carolyn T.</au><au>Thorpe, Joshua M.</au><au>Sileanu, Florentina E.</au><au>Cashy, John P.</au><au>Hale, Jennifer A.</au><au>Mor, Maria K.</au><au>Radomski, Thomas R.</au><au>Donohue, Julie M.</au><au>Hausmann, Leslie R.M.</au><au>Hanlon, Joseph T.</au><au>Good, Chester B.</au><au>Fine, Michael J.</au><au>Gellad, Walid F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans</atitle><jtitle>Research in social and administrative pharmacy</jtitle><addtitle>Res Social Adm Pharm</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>15</volume><issue>8</issue><spage>1007</spage><epage>1013</epage><pages>1007-1013</pages><issn>1551-7411</issn><eissn>1934-8150</eissn><abstract>Few studies have assessed prescription opioid supply preceding death in individuals dying from unintentional prescription opioid overdoses, or described the characteristics of these individuals, particularly among Veterans.
To describe the history of prescription opioid supply preceding prescription opioid overdose death among Veterans.
In a national cohort of Veterans who filled ≥1 opioid prescriptions from the Veterans Health Administration (VA) or Medicare Part D during 2008–2013, we identified deaths from unintentional or undetermined-intent prescription opioid overdoses in 2012–2013. We captured opioid prescriptions using both linked VA and Part D data, and VA data only.
Among 1181 decedents, 643 (54.4%) had prescription opioid supply on the day of death, and 735 (62.2%) within 30 days based on linked data, compared to 40.1% and 46.7%, respectively, using VA data alone. Decedents with prescription opioid supply were significantly older and less likely to have alcohol or illicit drugs as co-occurring substances involved in the overdose. Using linked data, 241 (20.4%) decedents lacked prescription opioid supply within a year of death.
Many VA patients who die from prescription opioid overdose receive opioid prescriptions outside VA or not at all. It is important to supplement VA with non-VA data to more accurately measure prescription opioid exposure and improve opioid medication safety.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30385111</pmid><doi>10.1016/j.sapharm.2018.10.023</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5871-0000</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1551-7411 |
| ispartof | Research in social and administrative pharmacy, 2019-08, Vol.15 (8), p.1007-1013 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Analgesics, Opioid - adverse effects Drug overdose Drug Overdose - mortality Drug Prescriptions - statistics & numerical data Female Humans Male Medicare Part D Middle Aged Poisoning deaths Prescription opioids United States United States Department of Veterans Affairs - statistics & numerical data Veterans Veterans - statistics & numerical data Young Adult |
| title | Patterns of opioid prescriptions received prior to unintentional prescription opioid overdose death among Veterans |
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