Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia

[Display omitted] Adenylyl cyclases are key points for the integration of stimulatory and inhibitory G protein-coupled receptor (GPCR) signals. Adenylyl cyclase type 5 (AC5) is highly expressed in striatal medium spiny neurons (MSNs), and is known to play an important role in mediating striatal dopa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical pharmacology 2019-05, Vol.163, p.169-177
Hauptverfasser:	Doyle, T.B., Hayes, M.P., Chen, D.H., Raskind, W.H., Watts, V.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AC5 Adenylyl cyclase Adenylyl Cyclase Inhibitors - pharmacology Adenylyl Cyclases - genetics Adenylyl Cyclases - metabolism cAMP Dopamine Dose-Response Relationship, Drug Dyskinesia Dyskinesias - genetics Dyskinesias - metabolism Gain of Function Mutation - physiology Gene Knockdown Techniques Genetic Variation - physiology HEK293 Cells Humans Receptors, Dopamine D2 - agonists Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!