Current HIV Type 1 Molecular Epidemiology Profile and identification of Unique Recombinant Forms in Jakarta, Indonesia
HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involvin...
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| Veröffentlicht in: | AIDS research and human retroviruses 2009-07, Vol.25 (7), p.637-646 |
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| creator | SAHBANDAR, Ivo N TAKAHASHI, Kiyomi DJOERBAN, Zubairi FIRMANSYAH, Iman NAGANAWA, Satoshi MOTOMURA, Kazushi SATO, Hironori KITAMURA, Katsuhiko POHAN, Herdiman T SATO, Shigehiro |
| description | HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted in 2007 in Jakarta. The majority of participants were 16-30 years of age (64.9%) and 74.5% were male. The most frequent risk factor was injecting drug use (IDU) (45.7%) followed by heterosexual transmission (34.1%). Phylogenetic analysis of gag (p17 and p6) and env C2V3 regions showed 200 (96.2%) of 208 DNA samples were CRF01_AE and only 3 (1.4%) were subtype B. Five samples (2.4%) indicated discordant subtypes between the three aforementioned regions: three of them showed unique CRF01_AE/B recombination patterns in 2.3-kbp nucleotide sequences (from p17 to part of RT), including one sample showing similarity to CRF33_01B, reported previously in Malaysia. This study shows the current predominant subtype is CRF01_AE in every risk group, with a decreasing number of pure subtype B, and the first identification of CRF01_AE/B recombinant forms among HIV-1-seropositive Indonesians. |
| doi_str_mv | 10.1089/aid.2008.0266 |
| format | Article |
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The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted in 2007 in Jakarta. The majority of participants were 16-30 years of age (64.9%) and 74.5% were male. The most frequent risk factor was injecting drug use (IDU) (45.7%) followed by heterosexual transmission (34.1%). Phylogenetic analysis of gag (p17 and p6) and env C2V3 regions showed 200 (96.2%) of 208 DNA samples were CRF01_AE and only 3 (1.4%) were subtype B. Five samples (2.4%) indicated discordant subtypes between the three aforementioned regions: three of them showed unique CRF01_AE/B recombination patterns in 2.3-kbp nucleotide sequences (from p17 to part of RT), including one sample showing similarity to CRF33_01B, reported previously in Malaysia. This study shows the current predominant subtype is CRF01_AE in every risk group, with a decreasing number of pure subtype B, and the first identification of CRF01_AE/B recombinant forms among HIV-1-seropositive Indonesians.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/aid.2008.0266</identifier><identifier>PMID: 19621986</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>New Rochelle, NY: Liebert</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Care and treatment ; Child ; Child, Preschool ; Control ; Cross-Sectional Studies ; Demographic aspects ; Disease transmission ; Diseases ; Distribution ; DNA, Recombinant - genetics ; DNA, Viral - genetics ; Drug addicts ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Health aspects ; HIV infection ; HIV Infections - epidemiology ; HIV Infections - genetics ; HIV Infections - virology ; HIV seroprevalence ; HIV-1 - genetics ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Indonesia - epidemiology ; Infectious diseases ; Male ; Medical examination ; Medical sciences ; Methods ; Microbiology ; Middle Aged ; Miscellaneous ; Phylogeny ; Retrovirus ; Risk Factors ; Sequence Analysis, DNA ; Viral diseases ; Virology</subject><ispartof>AIDS research and human retroviruses, 2009-07, Vol.25 (7), p.637-646</ispartof><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Mary Ann Liebert, Inc.</rights><rights>Copyright 2009, Mary Ann Liebert, Inc., publishers 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-bbb8fe2ea033b560a98a8affa90581ee903c40c680027602684c63da8a53ee503</citedby><cites>FETCH-LOGICAL-c513t-bbb8fe2ea033b560a98a8affa90581ee903c40c680027602684c63da8a53ee503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3042,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21784623$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19621986$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAHBANDAR, Ivo N</creatorcontrib><creatorcontrib>TAKAHASHI, Kiyomi</creatorcontrib><creatorcontrib>DJOERBAN, Zubairi</creatorcontrib><creatorcontrib>FIRMANSYAH, Iman</creatorcontrib><creatorcontrib>NAGANAWA, Satoshi</creatorcontrib><creatorcontrib>MOTOMURA, Kazushi</creatorcontrib><creatorcontrib>SATO, Hironori</creatorcontrib><creatorcontrib>KITAMURA, Katsuhiko</creatorcontrib><creatorcontrib>POHAN, Herdiman T</creatorcontrib><creatorcontrib>SATO, Shigehiro</creatorcontrib><title>Current HIV Type 1 Molecular Epidemiology Profile and identification of Unique Recombinant Forms in Jakarta, Indonesia</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted in 2007 in Jakarta. The majority of participants were 16-30 years of age (64.9%) and 74.5% were male. The most frequent risk factor was injecting drug use (IDU) (45.7%) followed by heterosexual transmission (34.1%). Phylogenetic analysis of gag (p17 and p6) and env C2V3 regions showed 200 (96.2%) of 208 DNA samples were CRF01_AE and only 3 (1.4%) were subtype B. Five samples (2.4%) indicated discordant subtypes between the three aforementioned regions: three of them showed unique CRF01_AE/B recombination patterns in 2.3-kbp nucleotide sequences (from p17 to part of RT), including one sample showing similarity to CRF33_01B, reported previously in Malaysia. This study shows the current predominant subtype is CRF01_AE in every risk group, with a decreasing number of pure subtype B, and the first identification of CRF01_AE/B recombinant forms among HIV-1-seropositive Indonesians.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Control</subject><subject>Cross-Sectional Studies</subject><subject>Demographic aspects</subject><subject>Disease transmission</subject><subject>Diseases</subject><subject>Distribution</subject><subject>DNA, Recombinant - genetics</subject><subject>DNA, Viral - genetics</subject><subject>Drug addicts</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>HIV infection</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - virology</subject><subject>HIV seroprevalence</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Indonesia - epidemiology</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical examination</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Phylogeny</subject><subject>Retrovirus</subject><subject>Risk Factors</subject><subject>Sequence Analysis, DNA</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEUxwdR7Fo9epWA6MlZXzIz2eRSKEtrVyqKtF7Dm0xmjWaSNZkp7H9vhl2qBUFyCCSf932_vkXxksKSgpDv0XZLBiCWwDh_VCyorGgpamgeFwsQQpaMMXlSPEvpBwBIxpqnxQmVnFEp-KK4W08xGj-Sq803crPfGULJp-CMnhxGcrGznRlscGG7J19i6K0zBH1H8rMfbW81jjZ4Enpy6-2vyZCvRoehtR6z5GWIQyLWk4_4E-OI78jGd8GbZPF58aRHl8yL431a3F5e3KyvyuvPHzbr8-tSN7Qay7ZtRW-YQaiqtuGAUqDAvkcJjaDGSKh0DZoLALbieQKi1rzqMtNUxjRQnRZnB93d1A6m07nqiE7toh0w7lVAqx7-ePtdbcOd4jWXDWuywNujQAy5vzSqwSZtnENvwpQUXzWw4hz-CzJgNWOwyuDrA7hFZ5T1fciJ9Qyrcwa14DTnztTyH1Q-8z50HuK8iocB5SFAx5BSNP19kxTU7BSVnaJmp6jZKZl_9fdk_tBHa2TgzRHApNH1Eb226Z5jdCVqzqrqN-7Nxmg</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>SAHBANDAR, Ivo N</creator><creator>TAKAHASHI, Kiyomi</creator><creator>DJOERBAN, Zubairi</creator><creator>FIRMANSYAH, Iman</creator><creator>NAGANAWA, Satoshi</creator><creator>MOTOMURA, Kazushi</creator><creator>SATO, Hironori</creator><creator>KITAMURA, Katsuhiko</creator><creator>POHAN, Herdiman T</creator><creator>SATO, Shigehiro</creator><general>Liebert</general><general>Mary Ann Liebert, Inc</general><general>Mary Ann Liebert, Inc., publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090701</creationdate><title>Current HIV Type 1 Molecular Epidemiology Profile and identification of Unique Recombinant Forms in Jakarta, Indonesia</title><author>SAHBANDAR, Ivo N ; TAKAHASHI, Kiyomi ; DJOERBAN, Zubairi ; FIRMANSYAH, Iman ; NAGANAWA, Satoshi ; MOTOMURA, Kazushi ; SATO, Hironori ; KITAMURA, Katsuhiko ; POHAN, Herdiman T ; SATO, Shigehiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-bbb8fe2ea033b560a98a8affa90581ee903c40c680027602684c63da8a53ee503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Control</topic><topic>Cross-Sectional Studies</topic><topic>Demographic aspects</topic><topic>Disease transmission</topic><topic>Diseases</topic><topic>Distribution</topic><topic>DNA, Recombinant - genetics</topic><topic>DNA, Viral - genetics</topic><topic>Drug addicts</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>HIV infection</topic><topic>HIV Infections - epidemiology</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - virology</topic><topic>HIV seroprevalence</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Indonesia - epidemiology</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical examination</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Phylogeny</topic><topic>Retrovirus</topic><topic>Risk Factors</topic><topic>Sequence Analysis, DNA</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAHBANDAR, Ivo N</creatorcontrib><creatorcontrib>TAKAHASHI, Kiyomi</creatorcontrib><creatorcontrib>DJOERBAN, Zubairi</creatorcontrib><creatorcontrib>FIRMANSYAH, Iman</creatorcontrib><creatorcontrib>NAGANAWA, Satoshi</creatorcontrib><creatorcontrib>MOTOMURA, Kazushi</creatorcontrib><creatorcontrib>SATO, Hironori</creatorcontrib><creatorcontrib>KITAMURA, Katsuhiko</creatorcontrib><creatorcontrib>POHAN, Herdiman T</creatorcontrib><creatorcontrib>SATO, Shigehiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAHBANDAR, Ivo N</au><au>TAKAHASHI, Kiyomi</au><au>DJOERBAN, Zubairi</au><au>FIRMANSYAH, Iman</au><au>NAGANAWA, Satoshi</au><au>MOTOMURA, Kazushi</au><au>SATO, Hironori</au><au>KITAMURA, Katsuhiko</au><au>POHAN, Herdiman T</au><au>SATO, Shigehiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current HIV Type 1 Molecular Epidemiology Profile and identification of Unique Recombinant Forms in Jakarta, Indonesia</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>25</volume><issue>7</issue><spage>637</spage><epage>646</epage><pages>637-646</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>HIV infection is a major problem in Indonesia. The number of people living with HIV has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles of HIV/AIDS in Indonesia, a cross-sectional study involving 208 HIV-1-seropositive individuals was conducted in 2007 in Jakarta. The majority of participants were 16-30 years of age (64.9%) and 74.5% were male. The most frequent risk factor was injecting drug use (IDU) (45.7%) followed by heterosexual transmission (34.1%). Phylogenetic analysis of gag (p17 and p6) and env C2V3 regions showed 200 (96.2%) of 208 DNA samples were CRF01_AE and only 3 (1.4%) were subtype B. Five samples (2.4%) indicated discordant subtypes between the three aforementioned regions: three of them showed unique CRF01_AE/B recombination patterns in 2.3-kbp nucleotide sequences (from p17 to part of RT), including one sample showing similarity to CRF33_01B, reported previously in Malaysia. This study shows the current predominant subtype is CRF01_AE in every risk group, with a decreasing number of pure subtype B, and the first identification of CRF01_AE/B recombinant forms among HIV-1-seropositive Indonesians.</abstract><cop>New Rochelle, NY</cop><pub>Liebert</pub><pmid>19621986</pmid><doi>10.1089/aid.2008.0266</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-2229 |
| ispartof | AIDS research and human retroviruses, 2009-07, Vol.25 (7), p.637-646 |
| issn | 0889-2229 1931-8405 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult AIDS/HIV Biological and medical sciences Care and treatment Child Child, Preschool Control Cross-Sectional Studies Demographic aspects Disease transmission Diseases Distribution DNA, Recombinant - genetics DNA, Viral - genetics Drug addicts Epidemiology Female Fundamental and applied biological sciences. Psychology Health aspects HIV infection HIV Infections - epidemiology HIV Infections - genetics HIV Infections - virology HIV seroprevalence HIV-1 - genetics Human immunodeficiency virus Human viral diseases Humans Indonesia - epidemiology Infectious diseases Male Medical examination Medical sciences Methods Microbiology Middle Aged Miscellaneous Phylogeny Retrovirus Risk Factors Sequence Analysis, DNA Viral diseases Virology |
| title | Current HIV Type 1 Molecular Epidemiology Profile and identification of Unique Recombinant Forms in Jakarta, Indonesia |
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