AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate

Hypercholesterolemia, the driving force of atherosclerosis, accelerates the expansion and mobilization of hematopoietic stem and progenitor cells (HSPCs). The molecular determinants connecting hypercholesterolemia with hematopoiesis are unclear. Here, we report that a somite-derived prohematopoietic...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2019-03, Vol.363 (6431), p.1085-1088
Hauptverfasser:	Gu, Qilin, Yang, Xiaojie, Lv, Jie, Zhang, Jiaxiong, Xia, Bo, Kim, Jun-Dae, Wang, Ruoyu, Xiong, Feng, Meng, Shu, Clements, Thomas P, Tandon, Bhavna, Wagner, Daniel S, Diaz, Miguel F, Wenzel, Pamela L, Miller, Yury I, Traver, David, Cooke, John P, Li, Wenbo, Zon, Leonard I, Chen, Kaifu, Bai, Yongping, Fang, Longhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticholesteremic Agents - pharmacology Arteriosclerosis Atherosclerosis Atorvastatin - pharmacology Base Sequence Biosynthesis Cardiovascular disease Cardiovascular diseases Cell fate Cells (biology) Cholesterol Cholesterol - biosynthesis Chromatin Chromatin Immunoprecipitation Coronary Artery Disease - metabolism Efflux Embryogenesis Embryonic growth stage Endothelium Expansion Gene expression Gene Expression Regulation Gene sequencing Genomes Hematopoiesis Hematopoiesis - genetics Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hypercholesterolemia Hypercholesterolemia - metabolism Immunoprecipitation Leukocytes Lipoproteins Progenitor cells Proteins Racemases and Epimerases - metabolism Receptors, Notch - genetics Ribonucleic acid RNA Sterol Regulatory Element Binding Protein 2 - metabolism Transcription factors Transposase Zebrafish Zebrafish Proteins - metabolism
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