A Feedback Loop Formed by ATG7/Autophagy, FOXO3a/miR-145 and PD-L1 Regulates Stem-Like Properties and Invasion in Human Bladder Cancer

Programmed cell death protein 1 (PD-1) and its ligand PD-L1 blockade have been identified to target immune checkpoints to treat human cancers with durable clinical benefit. Several studies reveal that the response to PD-1-PD-L1 blockade might correlate with PD-L1 expression levels in tumor cells. Ho...

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Veröffentlicht in:	Cancers 2019-03, Vol.11 (3), p.349
Hauptverfasser:	Zhu, Junlan, Li, Yang, Luo, Yisi, Xu, Jiheng, Liufu, Huating, Tian, Zhongxian, Huang, Chao, Li, Jingxia, Huang, Chuanshu
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Apoptosis Autophagy Binding sites Bladder cancer Cell cycle Cell death Feedback FOXO3 protein Gene expression Immune checkpoint Immune system Immunotherapy L1 protein Medical prognosis MicroRNAs mRNA stability PD-1 protein PD-L1 protein Phagocytosis Protein expression Proteins Transcription Transcription factors Tumor cells Tumorigenesis
Online-Zugang:	Volltext
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