Liposomal Irinotecan for Treatment of Colorectal Cancer in a Preclinical Model

Colorectal cancer (CRC) is the most frequently diagnosed cancer and leading cause of cancer-related deaths worldwide. Because of the use of first-line CRC treatments, such as irinotecan (IRI), is hindered by dose-limiting side effects, improved drug delivery systems may have major clinical benefits...

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Veröffentlicht in:	Cancers 2019-02, Vol.11 (3), p.281
Hauptverfasser:	Huang, Jiao-Ren, Lee, Mei-Hsien, Li, Wen-Shan, Wu, Han-Chun
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioavailability Cancer Cancer therapies Clinical trials Colorectal cancer Colorectal carcinoma Doxorubicin Drug delivery Drug delivery systems Drugs Hemodialysis Intestinal microflora Irinotecan Medical prognosis Microbiota Nanoparticles Pharmacokinetics Prostaglandin E2 Tumors Xenografts
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