Impact of donor age on liver regeneration and function following adult living donor liver transplantation
The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age 50 years old; n=5) and a young group (age
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| Veröffentlicht in: | Experimental and therapeutic medicine 2019-05, Vol.17 (5), p.3965-3970 |
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| creator | Li, Mingyang Chu, Zhiqiang Tan, Zhijun Jin, Yanyu Xu, Min Ji, Qian |
| description | The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age 50 years old; n=5) and a young group (age |
| doi_str_mv | 10.3892/etm.2019.7454 |
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Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Alanine aminotransferase, aspartate aminotransferase, total bilirubin (TB) and prothrombin time were recorded 1-5 days postoperatively. The liver regeneration ratio (LRR) was recorded 7 and 15 days postoperatively in donors and at 0.5, 1, 3 and 6 months postoperatively in recipients by contrast-enhanced multi-slice spiral computed tomography. Notably, the LRR in the young donor group was significantly increased compared with that in the elderly donor group at 7 days postoperatively (P<0.05). Among recipients, TB in the elderly group was significantly increased compared with that in the young group at 1-5 days postoperatively (P<0.05). The residual liver regeneration rate was decreased and the time of jaundice was prolonged in recipients in the elderly group 7 days postoperatively, but donor age had little impact on the short-term outcome of the residual liver and graft.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2019.7454</identifier><identifier>PMID: 31007739</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Analysis ; Aspartate ; Bile ; Blood tests ; CAT scans ; Diagnostic imaging ; Health aspects ; Jaundice ; Liver diseases ; Liver regeneration ; Liver transplantation ; Liver transplants ; Medical ethics ; Medical imaging ; Organ transplantation ; Prothrombin ; Software ; Statistical analysis ; Studies ; Surgery ; Thrombin ; Tissue donation ; Tissue donors ; Tomography ; Veins & arteries</subject><ispartof>Experimental and therapeutic medicine, 2019-05, Vol.17 (5), p.3965-3970</ispartof><rights>COPYRIGHT 2019 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2019</rights><rights>Copyright © 2019, Spandidos Publications 2019</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-1142c4dc3c50cd032bc974b9657f44f23d3c4b3c12ba9fb18707a26b4efb88003</citedby><cites>FETCH-LOGICAL-c412t-1142c4dc3c50cd032bc974b9657f44f23d3c4b3c12ba9fb18707a26b4efb88003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468505/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468505/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31007739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Mingyang</creatorcontrib><creatorcontrib>Chu, Zhiqiang</creatorcontrib><creatorcontrib>Tan, Zhijun</creatorcontrib><creatorcontrib>Jin, Yanyu</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><creatorcontrib>Ji, Qian</creatorcontrib><title>Impact of donor age on liver regeneration and function following adult living donor liver transplantation</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Alanine aminotransferase, aspartate aminotransferase, total bilirubin (TB) and prothrombin time were recorded 1-5 days postoperatively. The liver regeneration ratio (LRR) was recorded 7 and 15 days postoperatively in donors and at 0.5, 1, 3 and 6 months postoperatively in recipients by contrast-enhanced multi-slice spiral computed tomography. Notably, the LRR in the young donor group was significantly increased compared with that in the elderly donor group at 7 days postoperatively (P<0.05). Among recipients, TB in the elderly group was significantly increased compared with that in the young group at 1-5 days postoperatively (P<0.05). The residual liver regeneration rate was decreased and the time of jaundice was prolonged in recipients in the elderly group 7 days postoperatively, but donor age had little impact on the short-term outcome of the residual liver and graft.</description><subject>Age</subject><subject>Analysis</subject><subject>Aspartate</subject><subject>Bile</subject><subject>Blood tests</subject><subject>CAT scans</subject><subject>Diagnostic imaging</subject><subject>Health aspects</subject><subject>Jaundice</subject><subject>Liver diseases</subject><subject>Liver regeneration</subject><subject>Liver transplantation</subject><subject>Liver transplants</subject><subject>Medical ethics</subject><subject>Medical imaging</subject><subject>Organ transplantation</subject><subject>Prothrombin</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Studies</subject><subject>Surgery</subject><subject>Thrombin</subject><subject>Tissue donation</subject><subject>Tissue donors</subject><subject>Tomography</subject><subject>Veins & arteries</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1vFSEUhonR2KZ26dZM4sbNXDl8DMzGpGnUNmniRteEYWCkYeAKMzX-e5nea9M2wgIOPOflHPIi9BbwjsqefLTLvCMY-p1gnL1ApyB60gIG_vK4x72EE3Reyi2ug3cgJX-NTihgLATtT5G_nvfaLE1yzZhiyo2ebJNiE_ydzU22k40268XXIx3Hxq3R3AcuhZB--zg1elzDsvFbcNA4JC9Zx7IPOi73-W_QK6dDsefH9Qz9-PL5--VVe_Pt6_XlxU1rGJClBWDEsNFQw7EZMSWD6QUb-o4Lx5gjdKSGDdQAGXTvBpACC026gVk3SIkxPUOfDrr7dZjtaGyshQS1z37W-Y9K2qunN9H_VFO6Ux3rJMe8Cnw4CuT0a7VlUbMvxobaiU1rUYQAEYQygIq-f4bepjXH2t5GYUlrPY-oSQerfHSpvms2UXXBJWdMCiIrtfsPVedoZ29StM7X8ycJ7SHB5FRKtu6hR8Bqs4eq9lCbPdRmj8q_e_wxD_Q_M9C_dJK2Kg</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Li, Mingyang</creator><creator>Chu, Zhiqiang</creator><creator>Tan, Zhijun</creator><creator>Jin, Yanyu</creator><creator>Xu, Min</creator><creator>Ji, Qian</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. Spandidos</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190501</creationdate><title>Impact of donor age on liver regeneration and function following adult living donor liver transplantation</title><author>Li, Mingyang ; Chu, Zhiqiang ; Tan, Zhijun ; Jin, Yanyu ; Xu, Min ; Ji, Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-1142c4dc3c50cd032bc974b9657f44f23d3c4b3c12ba9fb18707a26b4efb88003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Aspartate</topic><topic>Bile</topic><topic>Blood tests</topic><topic>CAT scans</topic><topic>Diagnostic imaging</topic><topic>Health aspects</topic><topic>Jaundice</topic><topic>Liver diseases</topic><topic>Liver regeneration</topic><topic>Liver transplantation</topic><topic>Liver transplants</topic><topic>Medical ethics</topic><topic>Medical imaging</topic><topic>Organ transplantation</topic><topic>Prothrombin</topic><topic>Software</topic><topic>Statistical analysis</topic><topic>Studies</topic><topic>Surgery</topic><topic>Thrombin</topic><topic>Tissue donation</topic><topic>Tissue donors</topic><topic>Tomography</topic><topic>Veins & arteries</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Mingyang</creatorcontrib><creatorcontrib>Chu, Zhiqiang</creatorcontrib><creatorcontrib>Tan, Zhijun</creatorcontrib><creatorcontrib>Jin, Yanyu</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><creatorcontrib>Ji, Qian</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental and therapeutic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Mingyang</au><au>Chu, Zhiqiang</au><au>Tan, Zhijun</au><au>Jin, Yanyu</au><au>Xu, Min</au><au>Ji, Qian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of donor age on liver regeneration and function following adult living donor liver transplantation</atitle><jtitle>Experimental and therapeutic medicine</jtitle><addtitle>Exp Ther Med</addtitle><date>2019-05-01</date><risdate>2019</risdate><volume>17</volume><issue>5</issue><spage>3965</spage><epage>3970</epage><pages>3965-3970</pages><issn>1792-0981</issn><eissn>1792-1015</eissn><abstract>The aim of the present study was to evaluate the impact of donor age on liver function and regeneration following living donor liver transplantation. Donors were divided into an elderly donor group (age >50 years old; n=8) and a young donor group (age <30 years old; n=35). The recipients were also divided into an elderly group (age >50 years old; n=5) and a young group (age <30 years old; n=25). Alanine aminotransferase, aspartate aminotransferase, total bilirubin (TB) and prothrombin time were recorded 1-5 days postoperatively. The liver regeneration ratio (LRR) was recorded 7 and 15 days postoperatively in donors and at 0.5, 1, 3 and 6 months postoperatively in recipients by contrast-enhanced multi-slice spiral computed tomography. Notably, the LRR in the young donor group was significantly increased compared with that in the elderly donor group at 7 days postoperatively (P<0.05). Among recipients, TB in the elderly group was significantly increased compared with that in the young group at 1-5 days postoperatively (P<0.05). The residual liver regeneration rate was decreased and the time of jaundice was prolonged in recipients in the elderly group 7 days postoperatively, but donor age had little impact on the short-term outcome of the residual liver and graft.</abstract><cop>Greece</cop><pub>Spandidos Publications</pub><pmid>31007739</pmid><doi>10.3892/etm.2019.7454</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Analysis Aspartate Bile Blood tests CAT scans Diagnostic imaging Health aspects Jaundice Liver diseases Liver regeneration Liver transplantation Liver transplants Medical ethics Medical imaging Organ transplantation Prothrombin Software Statistical analysis Studies Surgery Thrombin Tissue donation Tissue donors Tomography Veins & arteries |
| title | Impact of donor age on liver regeneration and function following adult living donor liver transplantation |
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