Presynaptic Diversity Revealed by Ca2+-Permeable AMPA Receptors at the Calyx of Held Synapse

GluA2-lacking Ca2+-permeable AMPARs (CP-AMPARs) play integral roles in synaptic plasticity and can mediate excitotoxic cellular signaling at glutamatergic synapses. However, the developmental profile of functional CP-AMPARs at the auditory brainstem remains poorly understood. Through a combination o...

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Veröffentlicht in:	The Journal of neuroscience 2019-04, Vol.39 (16), p.2981-2994
Hauptverfasser:	Lujan, Brendan, Dagostin, Andre, von Gersdorff, Henrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Auditory plasticity Brain stem Calcium imaging Calcium influx Calcium ions Calcium permeability Excitatory postsynaptic potentials Excitotoxicity Glutamatergic transmission Hearing Heterogeneity Nuclei (cytology) Open channels Permeability Plastic foam Potassium Receptors Synapses Synaptic plasticity Tetraethylammonium Trapezoid body α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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