A PKD1L3 splicing variant in taste buds is not cleaved at the G protein-coupled receptor proteolytic site

Mutations in polycystin proteins PKD1 and TRPP2 lead to autosomal dominant polycystic kidney disease. These two proteins form a receptor-ion channel complex on primary cilia. PKD1 undergoes an autoproteolysis at the N terminal G-protein-coupled receptor proteolytic site (GPS), which is essential for...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-03, Vol.512 (4), p.812-818
Hauptverfasser:	Kashyap, Parul, Ng, Courtney, Wang, Zhifei, Li, Bin, Arif Pavel, Mahmud, Martin, Hannah, Yu, Yong
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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