Clinical validation of coexisting driver mutations in colorectal cancers

Mutational profiling is recommended for selecting targeted therapy and predicting prognosis of metastatic colorectal cancer (CRC). Detection of coexisting mutations within the same pathway, which are usually mutually exclusive, raises the concern for potential laboratory errors. In this retrospectiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human pathology 2019-04, Vol.86, p.12-20
Hauptverfasser:	Zheng, Gang, Tseng, Li-Hui, Haley, Lisa, Ibrahim, Junaid, Bynum, Jennifer, Xian, Rena, Gocke, Christopher D., Eshleman, James R., Lin, Ming-Tseh
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles BRAF Coexisting mutation Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Deoxyribonucleic acid DNA DNA Mutational Analysis Gene Frequency Genes Genomics GTP Phosphohydrolases - genetics High-Throughput Nucleotide Sequencing Humans Kinases KRAS Laboratories Lung cancer Membrane Proteins - genetics Metastasis Mutation NRAS PIK3CA Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Retrospective Studies Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!