Survivin at a glance

Survivin at a glance

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant at...

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Veröffentlicht in:Journal of cell science 2019-04, Vol.132 (7)
Hauptverfasser: Wheatley, Sally P, Altieri, Dario C
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Cell Science at A Glance
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Altieri, Dario C
description Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.
doi_str_mv 10.1242/jcs.223826
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subjects Cell Science at A Glance
title Survivin at a glance
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