Manganese-Catalyzed α‑Alkylation of Ketones, Esters, and Amides Using Alcohols

Manganese-Catalyzed α‑Alkylation of Ketones, Esters, and Amides Using Alcohols

Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ( i Pr-PNP)­Mn­(H)­(CO)...

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Veröffentlicht in:ACS catalysis 2018-11, Vol.8 (11), p.10300-10305
Hauptverfasser: Chakraborty, Subrata, Daw, Prosenjit, Ben David, Yehoshoa, Milstein, David
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container_end_page 10305
container_issue 11
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container_title ACS catalysis
container_volume 8
creator Chakraborty, Subrata
Daw, Prosenjit
Ben David, Yehoshoa
Milstein, David
description Herein we report the manganese-catalyzed C–C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ( i Pr-PNP)­Mn­(H)­(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole byproduct.
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title Manganese-Catalyzed α‑Alkylation of Ketones, Esters, and Amides Using Alcohols
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