A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO₂ from an Oil Refinery
To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO₂), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8⁻14, in Sarroch (Italy). The first study entailed five monthly spirometric visi...
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| Veröffentlicht in: | International journal of environmental research and public health 2019-03, Vol.16 (6), p.1057 |
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| creator | Barbone, Fabio Catelan, Dolores Pistelli, Riccardo Accetta, Gabriele Grechi, Daniele Rusconi, Franca Biggeri, Annibale |
| description | To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO₂), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8⁻14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for history of respiratory symptoms were tested weekly (20 times) with spirometry and fractional exhaled nitric oxide (FeNO) measurement (Panel 20). Baseline questionnaires and daily diaries were recorded. SO₂, NO₂, PM
and O₃ were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 µg/m³ SO₂ increase at lag0⁻2 days determined a percent variation (PV) of -3.37 (90% confidence interval, CI: -5.39; -1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = -3.51 (90% CI: -4.77; -2.23) in Panel 20. We found a strong dose-response relation: 1-h SO₂ peaks >200 µg/m³ at lag2 days = FEV1 PV -2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 µg/m³ SO₂ increase at 8-h time lag and a strong dose-response relation. Exposure to SO₂ is strongly associated with reduction of lung function and an increase in airway inflammation. This new evidence of harmful effects of SO₂ peaks should induce regulatory intervention. |
| doi_str_mv | 10.3390/ijerph16061057 |
| format | Article |
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and O₃ were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 µg/m³ SO₂ increase at lag0⁻2 days determined a percent variation (PV) of -3.37 (90% confidence interval, CI: -5.39; -1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = -3.51 (90% CI: -4.77; -2.23) in Panel 20. We found a strong dose-response relation: 1-h SO₂ peaks >200 µg/m³ at lag2 days = FEV1 PV -2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 µg/m³ SO₂ increase at 8-h time lag and a strong dose-response relation. Exposure to SO₂ is strongly associated with reduction of lung function and an increase in airway inflammation. This new evidence of harmful effects of SO₂ peaks should induce regulatory intervention.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph16061057</identifier><identifier>PMID: 30909566</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adolescent ; Air Pollutants - adverse effects ; Air pollution ; Asthma ; Bronchi - drug effects ; Bronchi - physiopathology ; Child ; Coal-fired power plants ; Correlation analysis ; Dose-Response Relationship, Drug ; Emissions ; Environmental protection ; Female ; Forced Expiratory Volume - drug effects ; Humans ; Industrial plant emissions ; Inflammation - chemically induced ; Italy ; Longitudinal studies ; Lung - drug effects ; Lung - physiopathology ; Male ; Nitric Oxide - analysis ; Nitrogen dioxide ; Petrochemicals industry ; Petroleum refineries ; Pollutants ; Population ; Questionnaires ; Refineries ; Respiratory function ; Respiratory Function Tests ; Short term ; Socioeconomic factors ; Spirometry ; Statistical analysis ; Studies ; Sulfur dioxide ; Sulfur Dioxide - adverse effects ; Time lag</subject><ispartof>International journal of environmental research and public health, 2019-03, Vol.16 (6), p.1057</ispartof><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-4dd31f6f0419149383ebe490c5a670e7b57f4d93321cb983449e21b57f00010b3</citedby><cites>FETCH-LOGICAL-c418t-4dd31f6f0419149383ebe490c5a670e7b57f4d93321cb983449e21b57f00010b3</cites><orcidid>0000-0003-1337-5111</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466338/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466338/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30909566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barbone, Fabio</creatorcontrib><creatorcontrib>Catelan, Dolores</creatorcontrib><creatorcontrib>Pistelli, Riccardo</creatorcontrib><creatorcontrib>Accetta, Gabriele</creatorcontrib><creatorcontrib>Grechi, Daniele</creatorcontrib><creatorcontrib>Rusconi, Franca</creatorcontrib><creatorcontrib>Biggeri, Annibale</creatorcontrib><title>A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO₂ from an Oil Refinery</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>To determine the acute effects on respiratory function of children exposed to sulphur dioxide (SO₂), we conducted two population-based longitudinal investigations near a major oil refinery. We enrolled 233 children, age 8⁻14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for history of respiratory symptoms were tested weekly (20 times) with spirometry and fractional exhaled nitric oxide (FeNO) measurement (Panel 20). Baseline questionnaires and daily diaries were recorded. SO₂, NO₂, PM
and O₃ were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 µg/m³ SO₂ increase at lag0⁻2 days determined a percent variation (PV) of -3.37 (90% confidence interval, CI: -5.39; -1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = -3.51 (90% CI: -4.77; -2.23) in Panel 20. We found a strong dose-response relation: 1-h SO₂ peaks >200 µg/m³ at lag2 days = FEV1 PV -2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 µg/m³ SO₂ increase at 8-h time lag and a strong dose-response relation. Exposure to SO₂ is strongly associated with reduction of lung function and an increase in airway inflammation. 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We enrolled 233 children, age 8⁻14, in Sarroch (Italy). The first study entailed five monthly spirometric visits (Panel 5). In a subgroup, children positive for history of respiratory symptoms were tested weekly (20 times) with spirometry and fractional exhaled nitric oxide (FeNO) measurement (Panel 20). Baseline questionnaires and daily diaries were recorded. SO₂, NO₂, PM
and O₃ were measured by monitoring stations. Multiple regression models were fitted. Using a multipollutant model, we found that a 10 µg/m³ SO₂ increase at lag0⁻2 days determined a percent variation (PV) of -3.37 (90% confidence interval, CI: -5.39; -1.30) for forced expiratory volume after one second (FEV1) in Panel 5 and a PV = -3.51 (90% CI: -4.77; -2.23) in Panel 20. We found a strong dose-response relation: 1-h SO₂ peaks >200 µg/m³ at lag2 days = FEV1 PV -2.49. For FeNO, we found a PV = 38.12 (90% CI: 12.88; 69.01) for each 10 µg/m³ SO₂ increase at 8-h time lag and a strong dose-response relation. Exposure to SO₂ is strongly associated with reduction of lung function and an increase in airway inflammation. This new evidence of harmful effects of SO₂ peaks should induce regulatory intervention.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>30909566</pmid><doi>10.3390/ijerph16061057</doi><orcidid>https://orcid.org/0000-0003-1337-5111</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Air Pollutants - adverse effects Air pollution Asthma Bronchi - drug effects Bronchi - physiopathology Child Coal-fired power plants Correlation analysis Dose-Response Relationship, Drug Emissions Environmental protection Female Forced Expiratory Volume - drug effects Humans Industrial plant emissions Inflammation - chemically induced Italy Longitudinal studies Lung - drug effects Lung - physiopathology Male Nitric Oxide - analysis Nitrogen dioxide Petrochemicals industry Petroleum refineries Pollutants Population Questionnaires Refineries Respiratory function Respiratory Function Tests Short term Socioeconomic factors Spirometry Statistical analysis Studies Sulfur dioxide Sulfur Dioxide - adverse effects Time lag |
| title | A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO₂ from an Oil Refinery |
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