Topological Analysis of Transthyretin Disassembly Mechanism: Surface-Induced Dissociation Reveals Hidden Reaction Pathways

The proposed mechanism of fibril formation of transthyretin (TTR) involves self-assembly of partially unfolded monomers. However, the mechanism(s) of disassembly to monomer and potential intermediates involved in this process are not fully understood. In this study, native mass spectrometry and surf...

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Veröffentlicht in:	Analytical chemistry (Washington) 2019-02, Vol.91 (3), p.2345-2351
Hauptverfasser:	Shirzadeh, Mehdi, Boone, Christopher D, Laganowsky, Arthur, Russell, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Complex formation Dimers Dismantling Exchanging Intermediates Ionic strength Ions Kinetics Mass spectrometry Mass spectroscopy Monomers Proteins Reaction kinetics Self-assembly Temperature effects Topology Transthyretin
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