Group behaviour therapy programmes for smoking cessation
Background Group therapy offers individuals the opportunity to learn behavioural techniques for smoking cessation, and to provide each other with mutual support. Objectives To determine the effect of group‐delivered behavioural interventions in achieving long‐term smoking cessation. Search methods W...
Gespeichert in:
Veröffentlicht in: | Cochrane database of systematic reviews 2017-03, Vol.2017 (3), p.CD001007 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 3 |
container_start_page | CD001007 |
container_title | Cochrane database of systematic reviews |
container_volume | 2017 |
creator | Stead, Lindsay F Carroll, Allison J Lancaster, Tim Stead, Lindsay F |
description | Background
Group therapy offers individuals the opportunity to learn behavioural techniques for smoking cessation, and to provide each other with mutual support.
Objectives
To determine the effect of group‐delivered behavioural interventions in achieving long‐term smoking cessation.
Search methods
We searched the Cochrane Tobacco Addiction Group Specialized Register, using the terms 'behavior therapy', 'cognitive therapy', 'psychotherapy' or 'group therapy', in May 2016.
Selection criteria
Randomized trials that compared group therapy with self‐help, individual counselling, another intervention or no intervention (including usual care or a waiting‐list control). We also considered trials that compared more than one group programme. We included those trials with a minimum of two group meetings, and follow‐up of smoking status at least six months after the start of the programme. We excluded trials in which group therapy was provided to both active therapy and placebo arms of trials of pharmacotherapies, unless they had a factorial design.
Data collection and analysis
Two review authors extracted data in duplicate on the participants, the interventions provided to the groups and the controls, including programme length, intensity and main components, the outcome measures, method of randomization, and completeness of follow‐up. The main outcome measure was abstinence from smoking after at least six months follow‐up in participants smoking at baseline. We used the most rigorous definition of abstinence in each trial, and biochemically‐validated rates where available. We analysed participants lost to follow‐up as continuing smokers. We expressed effects as a risk ratio for cessation. Where possible, we performed meta‐analysis using a fixed‐effect (Mantel‐Haenszel) model. We assessed the quality of evidence within each study and comparison, using the Cochrane 'Risk of bias' tool and GRADE criteria.
Main results
Sixty‐six trials met our inclusion criteria for one or more of the comparisons in the review. Thirteen trials compared a group programme with a self‐help programme; there was an increase in cessation with the use of a group programme (N = 4395, risk ratio (RR) 1.88, 95% confidence interval (CI) 1.52 to 2.33, I2 = 0%). We judged the GRADE quality of evidence to be moderate, downgraded due to there being few studies at low risk of bias. Fourteen trials compared a group programme with brief support from a health care provider. There was a small increase in c |
doi_str_mv | 10.1002/14651858.CD001007.pub3 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6464070</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1883181488</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5263-ee1fd17b068d9b0b3e3d8a30eb0e56dd087a0011a1baa1d241c65957d5cc3a883</originalsourceid><addsrcrecordid>eNqFkF9PgzAUxRujcTr9CguPvjBbCqW8mOjUabLEF31uSrkMFCi2MLNvb3F_Mn3xqU3PuefXexCaEDwlGAfXJGQR4RGfzu4xdi_xtO1TeoTOBsEflOOD-widW_uOMWVJEJ-iUcApI2ESnyE-N7pvvRQKuSp1b7yuACPbtdcavTSyrsF6uTaerfVH2Sw9BdbKrtTNBTrJZWXhcnuO0dvjw-vsyV-8zJ9ntwtfRQGjPgDJMxKnmPEsSXFKgWZcUgwphohlGeaxdAsQSVIpSRaERLEoieIsUopKzukY3Wxy3X41ZAqazshKtKaspVkLLUvxW2nKQiz1SrCQhTjGLuBqG2D0Zw-2E3VpFVSVbED3VhAHIZyEPyy2sSqjrTWQ7zEEi6F2satd7Gof4NQNTg4_uR_b9ewMdxvDV1nBWiitCuP4_-T-oXwDk4aUJA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1883181488</pqid></control><display><type>article</type><title>Group behaviour therapy programmes for smoking cessation</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Cochrane Library</source><source>Alma/SFX Local Collection</source><creator>Stead, Lindsay F ; Carroll, Allison J ; Lancaster, Tim ; Stead, Lindsay F</creator><creatorcontrib>Stead, Lindsay F ; Carroll, Allison J ; Lancaster, Tim ; Stead, Lindsay F</creatorcontrib><description>Background
Group therapy offers individuals the opportunity to learn behavioural techniques for smoking cessation, and to provide each other with mutual support.
Objectives
To determine the effect of group‐delivered behavioural interventions in achieving long‐term smoking cessation.
Search methods
We searched the Cochrane Tobacco Addiction Group Specialized Register, using the terms 'behavior therapy', 'cognitive therapy', 'psychotherapy' or 'group therapy', in May 2016.
Selection criteria
Randomized trials that compared group therapy with self‐help, individual counselling, another intervention or no intervention (including usual care or a waiting‐list control). We also considered trials that compared more than one group programme. We included those trials with a minimum of two group meetings, and follow‐up of smoking status at least six months after the start of the programme. We excluded trials in which group therapy was provided to both active therapy and placebo arms of trials of pharmacotherapies, unless they had a factorial design.
Data collection and analysis
Two review authors extracted data in duplicate on the participants, the interventions provided to the groups and the controls, including programme length, intensity and main components, the outcome measures, method of randomization, and completeness of follow‐up. The main outcome measure was abstinence from smoking after at least six months follow‐up in participants smoking at baseline. We used the most rigorous definition of abstinence in each trial, and biochemically‐validated rates where available. We analysed participants lost to follow‐up as continuing smokers. We expressed effects as a risk ratio for cessation. Where possible, we performed meta‐analysis using a fixed‐effect (Mantel‐Haenszel) model. We assessed the quality of evidence within each study and comparison, using the Cochrane 'Risk of bias' tool and GRADE criteria.
Main results
Sixty‐six trials met our inclusion criteria for one or more of the comparisons in the review. Thirteen trials compared a group programme with a self‐help programme; there was an increase in cessation with the use of a group programme (N = 4395, risk ratio (RR) 1.88, 95% confidence interval (CI) 1.52 to 2.33, I2 = 0%). We judged the GRADE quality of evidence to be moderate, downgraded due to there being few studies at low risk of bias. Fourteen trials compared a group programme with brief support from a health care provider. There was a small increase in cessation (N = 7286, RR 1.22, 95% CI 1.03 to 1.43, I2 = 59%). We judged the GRADE quality of evidence to be low, downgraded due to inconsistency in addition to risk of bias. There was also low quality evidence of benefit of a group programme compared to no‐intervention controls, (9 trials, N = 1098, RR 2.60, 95% CI 1.80 to 3.76 I2 = 55%). We did not detect evidence that group therapy was more effective than a similar intensity of individual counselling (6 trials, N = 980, RR 0.99, 95% CI 0.76 to 1.28, I2 = 9%). Programmes which included components for increasing cognitive and behavioural skills were not shown to be more effective than same‐length or shorter programmes without these components.
Authors' conclusions
Group therapy is better for helping people stop smoking than self‐help, and other less intensive interventions. There is not enough evidence to evaluate whether groups are more effective, or cost‐effective, than intensive individual counselling. There is not enough evidence to support the use of particular psychological components in a programme beyond the support and skills training normally included.</description><identifier>ISSN: 1465-1858</identifier><identifier>ISSN: 1469-493X</identifier><identifier>EISSN: 1465-1858</identifier><identifier>EISSN: 1469-493X</identifier><identifier>DOI: 10.1002/14651858.CD001007.pub3</identifier><identifier>PMID: 28361497</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Behavior Therapy ; Behavior Therapy - methods ; Behavioural therapy ; By treatment type ; Counseling ; Humans ; Interventions to help smokers and other tobacco users to quit ; Lungs & airways ; Medicine General & Introductory Medical Sciences ; Program Evaluation ; Psychological approaches ; Psychotherapy, Group ; Randomized Controlled Trials as Topic ; Self-Help Groups ; Smoking ; Smoking - drug therapy ; Smoking Cessation ; Smoking Cessation - methods ; Smoking Cessation - statistics & numerical data ; Smoking Prevention ; Tobacco ; Tobacco, drugs & alcohol</subject><ispartof>Cochrane database of systematic reviews, 2017-03, Vol.2017 (3), p.CD001007</ispartof><rights>Copyright © 2017 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5263-ee1fd17b068d9b0b3e3d8a30eb0e56dd087a0011a1baa1d241c65957d5cc3a883</citedby><cites>FETCH-LOGICAL-c5263-ee1fd17b068d9b0b3e3d8a30eb0e56dd087a0011a1baa1d241c65957d5cc3a883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28361497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stead, Lindsay F</creatorcontrib><creatorcontrib>Carroll, Allison J</creatorcontrib><creatorcontrib>Lancaster, Tim</creatorcontrib><creatorcontrib>Stead, Lindsay F</creatorcontrib><title>Group behaviour therapy programmes for smoking cessation</title><title>Cochrane database of systematic reviews</title><addtitle>Cochrane Database Syst Rev</addtitle><description>Background
Group therapy offers individuals the opportunity to learn behavioural techniques for smoking cessation, and to provide each other with mutual support.
Objectives
To determine the effect of group‐delivered behavioural interventions in achieving long‐term smoking cessation.
Search methods
We searched the Cochrane Tobacco Addiction Group Specialized Register, using the terms 'behavior therapy', 'cognitive therapy', 'psychotherapy' or 'group therapy', in May 2016.
Selection criteria
Randomized trials that compared group therapy with self‐help, individual counselling, another intervention or no intervention (including usual care or a waiting‐list control). We also considered trials that compared more than one group programme. We included those trials with a minimum of two group meetings, and follow‐up of smoking status at least six months after the start of the programme. We excluded trials in which group therapy was provided to both active therapy and placebo arms of trials of pharmacotherapies, unless they had a factorial design.
Data collection and analysis
Two review authors extracted data in duplicate on the participants, the interventions provided to the groups and the controls, including programme length, intensity and main components, the outcome measures, method of randomization, and completeness of follow‐up. The main outcome measure was abstinence from smoking after at least six months follow‐up in participants smoking at baseline. We used the most rigorous definition of abstinence in each trial, and biochemically‐validated rates where available. We analysed participants lost to follow‐up as continuing smokers. We expressed effects as a risk ratio for cessation. Where possible, we performed meta‐analysis using a fixed‐effect (Mantel‐Haenszel) model. We assessed the quality of evidence within each study and comparison, using the Cochrane 'Risk of bias' tool and GRADE criteria.
Main results
Sixty‐six trials met our inclusion criteria for one or more of the comparisons in the review. Thirteen trials compared a group programme with a self‐help programme; there was an increase in cessation with the use of a group programme (N = 4395, risk ratio (RR) 1.88, 95% confidence interval (CI) 1.52 to 2.33, I2 = 0%). We judged the GRADE quality of evidence to be moderate, downgraded due to there being few studies at low risk of bias. Fourteen trials compared a group programme with brief support from a health care provider. There was a small increase in cessation (N = 7286, RR 1.22, 95% CI 1.03 to 1.43, I2 = 59%). We judged the GRADE quality of evidence to be low, downgraded due to inconsistency in addition to risk of bias. There was also low quality evidence of benefit of a group programme compared to no‐intervention controls, (9 trials, N = 1098, RR 2.60, 95% CI 1.80 to 3.76 I2 = 55%). We did not detect evidence that group therapy was more effective than a similar intensity of individual counselling (6 trials, N = 980, RR 0.99, 95% CI 0.76 to 1.28, I2 = 9%). Programmes which included components for increasing cognitive and behavioural skills were not shown to be more effective than same‐length or shorter programmes without these components.
Authors' conclusions
Group therapy is better for helping people stop smoking than self‐help, and other less intensive interventions. There is not enough evidence to evaluate whether groups are more effective, or cost‐effective, than intensive individual counselling. There is not enough evidence to support the use of particular psychological components in a programme beyond the support and skills training normally included.</description><subject>Behavior Therapy</subject><subject>Behavior Therapy - methods</subject><subject>Behavioural therapy</subject><subject>By treatment type</subject><subject>Counseling</subject><subject>Humans</subject><subject>Interventions to help smokers and other tobacco users to quit</subject><subject>Lungs & airways</subject><subject>Medicine General & Introductory Medical Sciences</subject><subject>Program Evaluation</subject><subject>Psychological approaches</subject><subject>Psychotherapy, Group</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Self-Help Groups</subject><subject>Smoking</subject><subject>Smoking - drug therapy</subject><subject>Smoking Cessation</subject><subject>Smoking Cessation - methods</subject><subject>Smoking Cessation - statistics & numerical data</subject><subject>Smoking Prevention</subject><subject>Tobacco</subject><subject>Tobacco, drugs & alcohol</subject><issn>1465-1858</issn><issn>1469-493X</issn><issn>1465-1858</issn><issn>1469-493X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RWY</sourceid><sourceid>EIF</sourceid><recordid>eNqFkF9PgzAUxRujcTr9CguPvjBbCqW8mOjUabLEF31uSrkMFCi2MLNvb3F_Mn3xqU3PuefXexCaEDwlGAfXJGQR4RGfzu4xdi_xtO1TeoTOBsEflOOD-widW_uOMWVJEJ-iUcApI2ESnyE-N7pvvRQKuSp1b7yuACPbtdcavTSyrsF6uTaerfVH2Sw9BdbKrtTNBTrJZWXhcnuO0dvjw-vsyV-8zJ9ntwtfRQGjPgDJMxKnmPEsSXFKgWZcUgwphohlGeaxdAsQSVIpSRaERLEoieIsUopKzukY3Wxy3X41ZAqazshKtKaspVkLLUvxW2nKQiz1SrCQhTjGLuBqG2D0Zw-2E3VpFVSVbED3VhAHIZyEPyy2sSqjrTWQ7zEEi6F2satd7Gof4NQNTg4_uR_b9ewMdxvDV1nBWiitCuP4_-T-oXwDk4aUJA</recordid><startdate>20170331</startdate><enddate>20170331</enddate><creator>Stead, Lindsay F</creator><creator>Carroll, Allison J</creator><creator>Lancaster, Tim</creator><creator>Stead, Lindsay F</creator><general>John Wiley & Sons, Ltd</general><scope>7PX</scope><scope>RWY</scope><scope>ZYTZH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170331</creationdate><title>Group behaviour therapy programmes for smoking cessation</title><author>Stead, Lindsay F ; Carroll, Allison J ; Lancaster, Tim ; Stead, Lindsay F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5263-ee1fd17b068d9b0b3e3d8a30eb0e56dd087a0011a1baa1d241c65957d5cc3a883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Behavior Therapy</topic><topic>Behavior Therapy - methods</topic><topic>Behavioural therapy</topic><topic>By treatment type</topic><topic>Counseling</topic><topic>Humans</topic><topic>Interventions to help smokers and other tobacco users to quit</topic><topic>Lungs & airways</topic><topic>Medicine General & Introductory Medical Sciences</topic><topic>Program Evaluation</topic><topic>Psychological approaches</topic><topic>Psychotherapy, Group</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Self-Help Groups</topic><topic>Smoking</topic><topic>Smoking - drug therapy</topic><topic>Smoking Cessation</topic><topic>Smoking Cessation - methods</topic><topic>Smoking Cessation - statistics & numerical data</topic><topic>Smoking Prevention</topic><topic>Tobacco</topic><topic>Tobacco, drugs & alcohol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stead, Lindsay F</creatorcontrib><creatorcontrib>Carroll, Allison J</creatorcontrib><creatorcontrib>Lancaster, Tim</creatorcontrib><creatorcontrib>Stead, Lindsay F</creatorcontrib><collection>Wiley-Blackwell Cochrane Library</collection><collection>Cochrane Library</collection><collection>Cochrane Library (Open Aceess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cochrane database of systematic reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stead, Lindsay F</au><au>Carroll, Allison J</au><au>Lancaster, Tim</au><au>Stead, Lindsay F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Group behaviour therapy programmes for smoking cessation</atitle><jtitle>Cochrane database of systematic reviews</jtitle><addtitle>Cochrane Database Syst Rev</addtitle><date>2017-03-31</date><risdate>2017</risdate><volume>2017</volume><issue>3</issue><spage>CD001007</spage><pages>CD001007-</pages><issn>1465-1858</issn><issn>1469-493X</issn><eissn>1465-1858</eissn><eissn>1469-493X</eissn><abstract>Background
Group therapy offers individuals the opportunity to learn behavioural techniques for smoking cessation, and to provide each other with mutual support.
Objectives
To determine the effect of group‐delivered behavioural interventions in achieving long‐term smoking cessation.
Search methods
We searched the Cochrane Tobacco Addiction Group Specialized Register, using the terms 'behavior therapy', 'cognitive therapy', 'psychotherapy' or 'group therapy', in May 2016.
Selection criteria
Randomized trials that compared group therapy with self‐help, individual counselling, another intervention or no intervention (including usual care or a waiting‐list control). We also considered trials that compared more than one group programme. We included those trials with a minimum of two group meetings, and follow‐up of smoking status at least six months after the start of the programme. We excluded trials in which group therapy was provided to both active therapy and placebo arms of trials of pharmacotherapies, unless they had a factorial design.
Data collection and analysis
Two review authors extracted data in duplicate on the participants, the interventions provided to the groups and the controls, including programme length, intensity and main components, the outcome measures, method of randomization, and completeness of follow‐up. The main outcome measure was abstinence from smoking after at least six months follow‐up in participants smoking at baseline. We used the most rigorous definition of abstinence in each trial, and biochemically‐validated rates where available. We analysed participants lost to follow‐up as continuing smokers. We expressed effects as a risk ratio for cessation. Where possible, we performed meta‐analysis using a fixed‐effect (Mantel‐Haenszel) model. We assessed the quality of evidence within each study and comparison, using the Cochrane 'Risk of bias' tool and GRADE criteria.
Main results
Sixty‐six trials met our inclusion criteria for one or more of the comparisons in the review. Thirteen trials compared a group programme with a self‐help programme; there was an increase in cessation with the use of a group programme (N = 4395, risk ratio (RR) 1.88, 95% confidence interval (CI) 1.52 to 2.33, I2 = 0%). We judged the GRADE quality of evidence to be moderate, downgraded due to there being few studies at low risk of bias. Fourteen trials compared a group programme with brief support from a health care provider. There was a small increase in cessation (N = 7286, RR 1.22, 95% CI 1.03 to 1.43, I2 = 59%). We judged the GRADE quality of evidence to be low, downgraded due to inconsistency in addition to risk of bias. There was also low quality evidence of benefit of a group programme compared to no‐intervention controls, (9 trials, N = 1098, RR 2.60, 95% CI 1.80 to 3.76 I2 = 55%). We did not detect evidence that group therapy was more effective than a similar intensity of individual counselling (6 trials, N = 980, RR 0.99, 95% CI 0.76 to 1.28, I2 = 9%). Programmes which included components for increasing cognitive and behavioural skills were not shown to be more effective than same‐length or shorter programmes without these components.
Authors' conclusions
Group therapy is better for helping people stop smoking than self‐help, and other less intensive interventions. There is not enough evidence to evaluate whether groups are more effective, or cost‐effective, than intensive individual counselling. There is not enough evidence to support the use of particular psychological components in a programme beyond the support and skills training normally included.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>28361497</pmid><doi>10.1002/14651858.CD001007.pub3</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1465-1858 |
ispartof | Cochrane database of systematic reviews, 2017-03, Vol.2017 (3), p.CD001007 |
issn | 1465-1858 1469-493X 1465-1858 1469-493X |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6464070 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cochrane Library; Alma/SFX Local Collection |
subjects | Behavior Therapy Behavior Therapy - methods Behavioural therapy By treatment type Counseling Humans Interventions to help smokers and other tobacco users to quit Lungs & airways Medicine General & Introductory Medical Sciences Program Evaluation Psychological approaches Psychotherapy, Group Randomized Controlled Trials as Topic Self-Help Groups Smoking Smoking - drug therapy Smoking Cessation Smoking Cessation - methods Smoking Cessation - statistics & numerical data Smoking Prevention Tobacco Tobacco, drugs & alcohol |
title | Group behaviour therapy programmes for smoking cessation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T17%3A31%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Group%20behaviour%20therapy%20programmes%20for%20smoking%20cessation&rft.jtitle=Cochrane%20database%20of%20systematic%20reviews&rft.au=Stead,%20Lindsay%20F&rft.date=2017-03-31&rft.volume=2017&rft.issue=3&rft.spage=CD001007&rft.pages=CD001007-&rft.issn=1465-1858&rft.eissn=1465-1858&rft_id=info:doi/10.1002/14651858.CD001007.pub3&rft_dat=%3Cproquest_pubme%3E1883181488%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1883181488&rft_id=info:pmid/28361497&rfr_iscdi=true |