Nrf2-Mediated Antioxidant Defense and Peroxiredoxin 6 Are Linked to Biosynthesis of Palmitic Acid Ester of 9-Hydroxystearic Acid

Fatty acid esters of hydroxy fatty acids (FAHFAs) are lipid mediators with promising antidiabetic and anti-inflammatory properties that are formed in white adipose tissue (WAT) via de novo lipogenesis, but their biosynthetic enzymes are unknown. Using a combination of lipidomics in WAT, quantitative...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-06, Vol.67 (6), p.1190-1199
Hauptverfasser:	Kuda, Ondrej, Brezinova, Marie, Silhavy, Jan, Landa, Vladimir, Zidek, Vaclav, Dodia, Chandra, Kreuchwig, Franziska, Vrbacky, Marek, Balas, Laurence, Durand, Thierry, Hübner, Norbert, Fisher, Aron B, Kopecky, Jan, Pravenec, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue, White - enzymology Adipose Tissue, White - metabolism Animal models Animals Antagonist drugs Anti-inflammatory agents Antidiabetics Antioxidants Biomarkers - metabolism CD36 antigen Diabetes Diabetes mellitus Esters Esters - chemistry Esters - metabolism Fatty acids Female Flavin Gene Expression Profiling Gene Expression Regulation, Enzymologic Genetics/Genomes/Proteomics/Metabolomics Glucose Glutathione Hypoglycemia Inbreeding Inflammation Insulin Life Sciences Linkage analysis Lipogenesis Male Metabolomics - methods Mice, Inbred C57BL Mice, Knockout NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative Stress Palmitic acid Palmitic Acid - chemistry Palmitic Acid - metabolism Peroxiredoxin Peroxiredoxin VI - genetics Peroxiredoxin VI - metabolism Pharmacology Quantitative trait loci Random Allocation Rats Rats, Inbred BN Rats, Inbred SHR Rats, Transgenic Stearic Acids - chemistry Stearic Acids - metabolism
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