Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes
To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores. This study was a prospective cohort study. The study group comprised 26 pat...
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| Veröffentlicht in: | Journal of Turkish Society of Obstetric and Gynecology 2019-03, Vol.16 (1), p.50-54 |
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| description | To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores.
This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns.
Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO
levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements.
It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject. |
| doi_str_mv | 10.4274/tjod.galenos.2019.84665 |
| format | Article |
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This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns.
Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO
levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements.
It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject.</description><identifier>ISSN: 2149-9322</identifier><identifier>ISSN: 1307-699X</identifier><identifier>EISSN: 2149-9330</identifier><identifier>DOI: 10.4274/tjod.galenos.2019.84665</identifier><identifier>PMID: 31019840</identifier><language>eng</language><publisher>Turkey: Türk Jinekoloji ve Obstetrik Derneği</publisher><subject>Age ; Apgar score ; Biomarkers ; Cesarean section ; Clinical Investigation ; Enzymes ; Fetuses ; Gynecology ; Health risk assessment ; Kadın Hastalıkları ; Obstetrics ; Pregnancy ; Studies ; Tıp ; Ultrasonic imaging ; Umbilical cord ; Velocity</subject><ispartof>Journal of Turkish Society of Obstetric and Gynecology, 2019-03, Vol.16 (1), p.50-54</ispartof><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright 2019 by Turkish Society of Obstetrics and Gynecology | Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-7af50f8cc63c2eb858efa7527cb8812d340210c8e06b40786657df0b6c4e41d13</citedby><orcidid>0000-0003-4484-0549 ; 0000-0002-7085-5878 ; 0000-0002-3993-4017</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463424/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463424/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31019840$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Çalışkan,Eray</contributor><creatorcontrib>Yakıştıran, Betül</creatorcontrib><creatorcontrib>Katlan, Doruk Cevdi</creatorcontrib><creatorcontrib>Yüce, Tuncay</creatorcontrib><creatorcontrib>Koç, Acar</creatorcontrib><title>Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes</title><title>Journal of Turkish Society of Obstetric and Gynecology</title><addtitle>Turk J Obstet Gynecol</addtitle><description>To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores.
This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns.
Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO
levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements.
It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject.</description><subject>Age</subject><subject>Apgar score</subject><subject>Biomarkers</subject><subject>Cesarean section</subject><subject>Clinical Investigation</subject><subject>Enzymes</subject><subject>Fetuses</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Kadın Hastalıkları</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Studies</subject><subject>Tıp</subject><subject>Ultrasonic imaging</subject><subject>Umbilical cord</subject><subject>Velocity</subject><issn>2149-9322</issn><issn>1307-699X</issn><issn>2149-9330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkUtvGyEUhVHVKonc_IV0pC6ajV1eMzCbSlHekpVs2jVimDs27hgcYFrl34exHSftCrh85-geHYS-EDzjVPDvaeXb2UL34HycUUzqmeRVVX5AJ5Twelozhj8e7pQeo9MYVxhjIoWoCT1Cx4xkleT4BHUPMATdF9q1hdGhtdoU1q2G8FysdfgNIeZn0UHKzCL4v2lZBIgpWJOsd1tZWoINedrr7Sj5YgPBOj1K_JCMX0P8jD51uo9wuj8n6NfN9c_Lu-n88fb-8mI-NVyINBW6K3EnjamYodDIUkKnRUmFaaQktGUcU4KNBFw1HAuZU4u2w01lOHDSEjZBP3a-m6FZQ2vApZxObYLNaZ6V11b9--PsUi38H1XxinHKs8H53iD4pyEnVWsbDfS9duCHqCglJSZCihH9-h-68kNwOV6meCkEZdl0gr7tKNuC7r3rrYM38P7q-mKupKy5yKTYkSb4GAN0h7UJVmPxaixe7YtXY_FqW3xWnr1PfdC91sxeAEf-rsA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Yakıştıran, Betül</creator><creator>Katlan, Doruk Cevdi</creator><creator>Yüce, Tuncay</creator><creator>Koç, Acar</creator><general>Türk Jinekoloji ve Obstetrik Derneği</general><general>Galenos Publishing House</general><general>Galenos Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4484-0549</orcidid><orcidid>https://orcid.org/0000-0002-7085-5878</orcidid><orcidid>https://orcid.org/0000-0002-3993-4017</orcidid></search><sort><creationdate>20190301</creationdate><title>Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes</title><author>Yakıştıran, Betül ; Katlan, Doruk Cevdi ; Yüce, Tuncay ; Koç, Acar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-7af50f8cc63c2eb858efa7527cb8812d340210c8e06b40786657df0b6c4e41d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Apgar score</topic><topic>Biomarkers</topic><topic>Cesarean section</topic><topic>Clinical Investigation</topic><topic>Enzymes</topic><topic>Fetuses</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Kadın Hastalıkları</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Studies</topic><topic>Tıp</topic><topic>Ultrasonic imaging</topic><topic>Umbilical cord</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yakıştıran, Betül</creatorcontrib><creatorcontrib>Katlan, Doruk Cevdi</creatorcontrib><creatorcontrib>Yüce, Tuncay</creatorcontrib><creatorcontrib>Koç, Acar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Idealonline online kütüphane - Journals</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Turkish Society of Obstetric and Gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yakıştıran, Betül</au><au>Katlan, Doruk Cevdi</au><au>Yüce, Tuncay</au><au>Koç, Acar</au><au>Çalışkan,Eray</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes</atitle><jtitle>Journal of Turkish Society of Obstetric and Gynecology</jtitle><addtitle>Turk J Obstet Gynecol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>16</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>2149-9322</issn><issn>1307-699X</issn><eissn>2149-9330</eissn><abstract>To compare the levels of umbilical cord blood Neuron-Specific Enolase (NSE) and troponin T and venous blood gas samples between healthy newborns and growth-retarded fetuses with impaired Doppler velocity or low APGAR scores.
This study was a prospective cohort study. The study group comprised 26 patients with intrauterine growth restriction and pathologic Doppler symptoms, and the control group included 24 healthy fetuses. Umbilical cord blood and blood gas samples were taken from all patients. The blood samples were centrifuged and sent to a laboratory to study NSE and troponin T Perinatal outcomes were evaluated from the medical records of the newborns.
Both groups were similar in terms of demographic characteristics. Fetuses with fetal growth restriction (FGR) were born earlier and had lower APGAR scores than the study group. Chronic hypoxemic fetuses in the study group had lower cord pH and HCO
levels. Further, troponin T levels were higher in the study group than in the control group. There were no major differences in Doppler velocity measurements.
It has been understood that cardiac and neuronal injury detection on fetuses with FGR, troponin T, and NSE are indicators that can be used. In the literature there are studies with heterogeneous paradigms using different indicators to find neuronal injury. As a result of this study, it is clear that to assess neonatal prognosis, wider-scoped and comparative studies will provide more information about the subject.</abstract><cop>Turkey</cop><pub>Türk Jinekoloji ve Obstetrik Derneği</pub><pmid>31019840</pmid><doi>10.4274/tjod.galenos.2019.84665</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-4484-0549</orcidid><orcidid>https://orcid.org/0000-0002-7085-5878</orcidid><orcidid>https://orcid.org/0000-0002-3993-4017</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Turkish Society of Obstetric and Gynecology, 2019-03, Vol.16 (1), p.50-54 |
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| source | PubMed Central; Alma/SFX Local Collection |
| subjects | Age Apgar score Biomarkers Cesarean section Clinical Investigation Enzymes Fetuses Gynecology Health risk assessment Kadın Hastalıkları Obstetrics Pregnancy Studies Tıp Ultrasonic imaging Umbilical cord Velocity |
| title | Neural and cardiac injury markers in fetal growth restriction and their relation to perinatal outcomes |
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