Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States
Background Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma. Methods We examined the associations between r...
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| Veröffentlicht in: | British journal of cancer 2019-04, Vol.120 (7), p.754-760 |
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| creator | Donley, Grayson M. Liu, Wayne T. Pfeiffer, Ruth M. McDonald, Emily C. Peters, Kamau O. Tucker, Margaret A. Cahoon, Elizabeth K. |
| description | Background
Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.
Methods
We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline.
Results
Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71;
P
for trend = 0.04) and late age at menopause (≥50 vs |
| doi_str_mv | 10.1038/s41416-019-0411-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6461881</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2202206993</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-548c58a5a354ab54c9f6eeddef480ba831084823f52a10ad19e8cef5022a48683</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rj6A7xIwKutVel0T_oiyOIXLAjqnkNNujLTy3QyJulV99ebZdZVD55CqKfet-AR4inCS4TWvMoaNfYN4NCARmyu74kVdq1q0Kj1fbECgHUDg4IT8Sjny_odwKwfipMWDOremJXwn_mQ4ri4Ml2x9ORKTPmF5B9xyyEuWe5immNguWSWFEY5BTeNHBzL6OXMewpxJkmV2crvceZQCVl2LC_CVHiUXwoVzo_FA0_7zE9u31Nx8e7t17MPzfmn9x_P3pw3Tq-hNJ02rjPUUdtp2nTaDb5nHkf22sCGTItgtFGt7xQh0IgDG8e-A6VIm960p-L1MfewbGYeHYeSaG8PaZop_bSRJvvvJEw7u41Xttc9GoM14PltQIrfFs7FXsYlhXqzVarWQD8MbaXwSLkUc07s7xoQ7I0ae1Rjqxp7o8Ze151nf592t_HbRQXUEch1FLac_lT_P_UXArqcHw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2202206993</pqid></control><display><type>article</type><title>Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Donley, Grayson M. ; Liu, Wayne T. ; Pfeiffer, Ruth M. ; McDonald, Emily C. ; Peters, Kamau O. ; Tucker, Margaret A. ; Cahoon, Elizabeth K.</creator><creatorcontrib>Donley, Grayson M. ; Liu, Wayne T. ; Pfeiffer, Ruth M. ; McDonald, Emily C. ; Peters, Kamau O. ; Tucker, Margaret A. ; Cahoon, Elizabeth K.</creatorcontrib><description>Background
Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.
Methods
We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline.
Results
Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71;
P
for trend = 0.04) and late age at menopause (≥50 vs <45 years: HR = 1.34, 95% CI: 1.13, 1.59;
P
for trend = 0.001). The relationship between ambient UVR and melanoma risk was highest among women with age at menarche ≤10 years (HR per UVR quartile increase = 1.29; 95% CI: 1.05, 1.58;
P
-interaction = 0.02). Melanoma risk was not associated with parity, age at first birth, use of oral contraceptives or use of menopausal hormone therapy.
Conclusions
Our findings suggest that increased melanoma risk is associated with early age at menarche and late age at menopause. Effect modification findings support the hypothesis that endogenous oestrogen exposure in childhood increases photocarcinogenicity. Future studies should include information on personal UVR exposure and sun sensitivity.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-019-0411-z</identifier><identifier>PMID: 30814688</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1813/1634 ; 631/67/2324 ; Age ; Age Factors ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Children ; Contraceptives ; Contraceptives, Oral, Hormonal - therapeutic use ; Drug Resistance ; Epidemiology ; Estrogen Replacement Therapy - statistics & numerical data ; Estrogens ; Estrogens - therapeutic use ; Exposure ; Female ; Health risk assessment ; Humans ; Incidence ; Melanoma ; Melanoma - epidemiology ; Menarche ; Menopause ; Middle Aged ; Molecular Medicine ; Oncology ; Oral contraceptives ; Photosensitization ; Post-menopause ; Proportional Hazards Models ; Prospective Studies ; Residential location ; Skin Neoplasms - epidemiology ; Ultraviolet radiation ; Ultraviolet Rays ; United States - epidemiology ; Whites</subject><ispartof>British journal of cancer, 2019-04, Vol.120 (7), p.754-760</ispartof><rights>The Author(s) 2019</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-548c58a5a354ab54c9f6eeddef480ba831084823f52a10ad19e8cef5022a48683</citedby><cites>FETCH-LOGICAL-c470t-548c58a5a354ab54c9f6eeddef480ba831084823f52a10ad19e8cef5022a48683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461881/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461881/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30814688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donley, Grayson M.</creatorcontrib><creatorcontrib>Liu, Wayne T.</creatorcontrib><creatorcontrib>Pfeiffer, Ruth M.</creatorcontrib><creatorcontrib>McDonald, Emily C.</creatorcontrib><creatorcontrib>Peters, Kamau O.</creatorcontrib><creatorcontrib>Tucker, Margaret A.</creatorcontrib><creatorcontrib>Cahoon, Elizabeth K.</creatorcontrib><title>Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.
Methods
We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline.
Results
Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71;
P
for trend = 0.04) and late age at menopause (≥50 vs <45 years: HR = 1.34, 95% CI: 1.13, 1.59;
P
for trend = 0.001). The relationship between ambient UVR and melanoma risk was highest among women with age at menarche ≤10 years (HR per UVR quartile increase = 1.29; 95% CI: 1.05, 1.58;
P
-interaction = 0.02). Melanoma risk was not associated with parity, age at first birth, use of oral contraceptives or use of menopausal hormone therapy.
Conclusions
Our findings suggest that increased melanoma risk is associated with early age at menarche and late age at menopause. Effect modification findings support the hypothesis that endogenous oestrogen exposure in childhood increases photocarcinogenicity. Future studies should include information on personal UVR exposure and sun sensitivity.</description><subject>631/67/1813/1634</subject><subject>631/67/2324</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Children</subject><subject>Contraceptives</subject><subject>Contraceptives, Oral, Hormonal - therapeutic use</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Estrogen Replacement Therapy - statistics & numerical data</subject><subject>Estrogens</subject><subject>Estrogens - therapeutic use</subject><subject>Exposure</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Incidence</subject><subject>Melanoma</subject><subject>Melanoma - epidemiology</subject><subject>Menarche</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Oral contraceptives</subject><subject>Photosensitization</subject><subject>Post-menopause</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Residential location</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays</subject><subject>United States - epidemiology</subject><subject>Whites</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU2LFDEQhoMo7rj6A7xIwKutVel0T_oiyOIXLAjqnkNNujLTy3QyJulV99ebZdZVD55CqKfet-AR4inCS4TWvMoaNfYN4NCARmyu74kVdq1q0Kj1fbECgHUDg4IT8Sjny_odwKwfipMWDOremJXwn_mQ4ri4Ml2x9ORKTPmF5B9xyyEuWe5immNguWSWFEY5BTeNHBzL6OXMewpxJkmV2crvceZQCVl2LC_CVHiUXwoVzo_FA0_7zE9u31Nx8e7t17MPzfmn9x_P3pw3Tq-hNJ02rjPUUdtp2nTaDb5nHkf22sCGTItgtFGt7xQh0IgDG8e-A6VIm960p-L1MfewbGYeHYeSaG8PaZop_bSRJvvvJEw7u41Xttc9GoM14PltQIrfFs7FXsYlhXqzVarWQD8MbaXwSLkUc07s7xoQ7I0ae1Rjqxp7o8Ze151nf592t_HbRQXUEch1FLac_lT_P_UXArqcHw</recordid><startdate>20190402</startdate><enddate>20190402</enddate><creator>Donley, Grayson M.</creator><creator>Liu, Wayne T.</creator><creator>Pfeiffer, Ruth M.</creator><creator>McDonald, Emily C.</creator><creator>Peters, Kamau O.</creator><creator>Tucker, Margaret A.</creator><creator>Cahoon, Elizabeth K.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20190402</creationdate><title>Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States</title><author>Donley, Grayson M. ; Liu, Wayne T. ; Pfeiffer, Ruth M. ; McDonald, Emily C. ; Peters, Kamau O. ; Tucker, Margaret A. ; Cahoon, Elizabeth K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-548c58a5a354ab54c9f6eeddef480ba831084823f52a10ad19e8cef5022a48683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>631/67/1813/1634</topic><topic>631/67/2324</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Research</topic><topic>Children</topic><topic>Contraceptives</topic><topic>Contraceptives, Oral, Hormonal - therapeutic use</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Estrogen Replacement Therapy - statistics & numerical data</topic><topic>Estrogens</topic><topic>Estrogens - therapeutic use</topic><topic>Exposure</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Incidence</topic><topic>Melanoma</topic><topic>Melanoma - epidemiology</topic><topic>Menarche</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Oral contraceptives</topic><topic>Photosensitization</topic><topic>Post-menopause</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Residential location</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays</topic><topic>United States - epidemiology</topic><topic>Whites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donley, Grayson M.</creatorcontrib><creatorcontrib>Liu, Wayne T.</creatorcontrib><creatorcontrib>Pfeiffer, Ruth M.</creatorcontrib><creatorcontrib>McDonald, Emily C.</creatorcontrib><creatorcontrib>Peters, Kamau O.</creatorcontrib><creatorcontrib>Tucker, Margaret A.</creatorcontrib><creatorcontrib>Cahoon, Elizabeth K.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donley, Grayson M.</au><au>Liu, Wayne T.</au><au>Pfeiffer, Ruth M.</au><au>McDonald, Emily C.</au><au>Peters, Kamau O.</au><au>Tucker, Margaret A.</au><au>Cahoon, Elizabeth K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2019-04-02</date><risdate>2019</risdate><volume>120</volume><issue>7</issue><spage>754</spage><epage>760</epage><pages>754-760</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><abstract>Background
Although the photosensitising effects of oestrogens may increase the impact of ultraviolet radiation (UVR) on melanoma risk, few prospective studies have comprehensively assessed the association between oestrogen-related factors and melanoma.
Methods
We examined the associations between reproductive factors, exogenous oestrogen use and first primary invasive melanoma among 167 503 non-Hispanic white, postmenopausal women in the NIH-AARP Diet and Health Study. Satellite-based ambient UVR estimates were linked to geocoded residential locations of participants at study baseline.
Results
Increased risk of melanoma was associated with early age at menarche (≤10 vs ≥15 years: HR = 1.25, 95% CI: 0.92, 1.71;
P
for trend = 0.04) and late age at menopause (≥50 vs <45 years: HR = 1.34, 95% CI: 1.13, 1.59;
P
for trend = 0.001). The relationship between ambient UVR and melanoma risk was highest among women with age at menarche ≤10 years (HR per UVR quartile increase = 1.29; 95% CI: 1.05, 1.58;
P
-interaction = 0.02). Melanoma risk was not associated with parity, age at first birth, use of oral contraceptives or use of menopausal hormone therapy.
Conclusions
Our findings suggest that increased melanoma risk is associated with early age at menarche and late age at menopause. Effect modification findings support the hypothesis that endogenous oestrogen exposure in childhood increases photocarcinogenicity. Future studies should include information on personal UVR exposure and sun sensitivity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30814688</pmid><doi>10.1038/s41416-019-0411-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67/1813/1634 631/67/2324 Age Age Factors Aged Biomedical and Life Sciences Biomedicine Cancer Research Children Contraceptives Contraceptives, Oral, Hormonal - therapeutic use Drug Resistance Epidemiology Estrogen Replacement Therapy - statistics & numerical data Estrogens Estrogens - therapeutic use Exposure Female Health risk assessment Humans Incidence Melanoma Melanoma - epidemiology Menarche Menopause Middle Aged Molecular Medicine Oncology Oral contraceptives Photosensitization Post-menopause Proportional Hazards Models Prospective Studies Residential location Skin Neoplasms - epidemiology Ultraviolet radiation Ultraviolet Rays United States - epidemiology Whites |
| title | Reproductive factors, exogenous hormone use and incidence of melanoma among women in the United States |
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