Ezrin promotes breast cancer progression by modulating AKT signals

Background Ezrin, which is known as a cytoskeleton linker protein, is closely linked with the metastatic progression of cancer and is frequently abnormally expressed in aggressive cancer types. However, the possible involvement of Ezrin in metastasis and angiogenesis in breast cancer remains unclear...

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Veröffentlicht in:	British journal of cancer 2019-04, Vol.120 (7), p.703-713
Hauptverfasser:	Li, Nan, Kong, Jienan, Lin, Zhenhua, Yang, Yang, Jin, Tiefeng, Xu, Ming, Sun, Jie, Chen, Liyan
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4028/67/1347 692/53 Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology AKT protein Angiogenesis Animals Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Research Case-Control Studies Cell Line, Tumor Cell Movement - genetics Cell Proliferation - genetics Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Cytoskeleton Disease Progression Drug Resistance Epidemiology Epithelium Ezrin Female Humans Kinases MCF-7 Cells Metastases Mice Mice, Nude Middle Aged Migration Molecular Medicine Neoplasm Invasiveness Neoplasm Staging Neoplasm Transplantation Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oncology Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Tumors
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