Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery
Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action an...
Gespeichert in:
| Veröffentlicht in: | Drug delivery 2019-01, Vol.26 (1), p.481-489 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 489 |
|---|---|
| container_issue | 1 |
| container_start_page | 481 |
| container_title | Drug delivery |
| container_volume | 26 |
| creator | Li, Mengshuang Lan, Jie Li, Xuefei Xin, Meng Wang, Hui Zhang, Fan Lu, Xiaohong Zhuang, Zengfang Wu, Xianggen |
| description | Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action and reduce side effects.
Methods: Diclofenac-loaded Rb1 micelles (Rb1-Dic micelles) were formulated, optimized, and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vivo corneal permeation, and in vivo anti-inflammatory efficacy.
Results: Rb1 self-assembled into micelles with ultra-small particle size ( |
| doi_str_mv | 10.1080/10717544.2019.1600077 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6461112</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_3b2812d03b654edca3e8034564404b16</doaj_id><sourcerecordid>2351040136</sourcerecordid><originalsourceid>FETCH-LOGICAL-c562t-2dd0b9f723b5637a209b1a63fcffcdd796c86d8270e90d36c66925edca99b3b33</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhgdRbK3-BCXg9awn3zNeiKVoWygKotchX7NmyU7WZGZl_70Zd1vsjTdJSJ48Jydv07zGsMLQwTsMEkvO2IoA7ldYAICUT5pzzAlugQn2tK4r0y7QWfOilE1FOkz48-aMQs8ll_i8Gb6kvY9ojlPWbdnqGNE2WB-jL8jo4h1KI1qHsfgxleA8-mbwe6TRLk1-nIKOaNRj2kU9DSlvUR1QsnPUGbk8r5HzMex9Prxsng06Fv_qNF80Pz5_-n510959vb69urxrLRdkaolzYPpBEmq4oFIT6A3Wgg52GKxzshe2E64jEnwPjgorRE-4d1b3vaGG0ovm9uh1SW_ULoetzgeVdFB_N1JeK52nYKNX1JD6Gw6oEZwtCuo7oIwLxoAZLKrrw9G1m822ArXfrOMj6eOTMfxU67RXggmMMamCtydBTr9mXya1SXMea_-KUI6BAaZLGX6kbE6lZD88VMCglqjVfdRqiVqdoq733vz7vIdb99lW4OMRCOOSjf6dcnRq0oeY8pD1aENR9P81_gD_Abki</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2351040136</pqid></control><display><type>article</type><title>Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery</title><source>Taylor & Francis Open Access</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Li, Mengshuang ; Lan, Jie ; Li, Xuefei ; Xin, Meng ; Wang, Hui ; Zhang, Fan ; Lu, Xiaohong ; Zhuang, Zengfang ; Wu, Xianggen</creator><creatorcontrib>Li, Mengshuang ; Lan, Jie ; Li, Xuefei ; Xin, Meng ; Wang, Hui ; Zhang, Fan ; Lu, Xiaohong ; Zhuang, Zengfang ; Wu, Xianggen</creatorcontrib><description>Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action and reduce side effects.
Methods: Diclofenac-loaded Rb1 micelles (Rb1-Dic micelles) were formulated, optimized, and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vivo corneal permeation, and in vivo anti-inflammatory efficacy.
Results: Rb1 self-assembled into micelles with ultra-small particle size (<8 nm) in a homogeneous distribution state (polydispersity index [PDI] < 0.3). Diclofenac was highly encapsulated into the micelles according to the weight ratios of Rb1 to diclofenac. The ophthalmic solution of Rb1-Dic micelle was simple to prepare. Rb1 had good cellular tolerance, and it also improved the cellular tolerance of the encapsulated diclofenac. Rb1-Dic micelles also showed non-irritants to the rabbit eyes. The use of Rb1 micelles significantly improved the in vivo corneal permeation as well as the anti-inflammatory efficacy of diclofenac when compared to commercial diclofenac eye drops.
Conclusion: Rb1 micelle formulations have great potential as a novel ocular drug delivery system to improve the bioavailability of drugs such as diclofenac.</description><identifier>ISSN: 1071-7544</identifier><identifier>EISSN: 1521-0464</identifier><identifier>DOI: 10.1080/10717544.2019.1600077</identifier><identifier>PMID: 30957571</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Bioavailability ; Chemical engineering ; Cornea ; Cytotoxicity ; diclofenac ; Drug delivery systems ; Ginsenoside Rb1 ; Hospitals ; Laboratory animals ; micelle ; Nanomaterials ; Nonsteroidal anti-inflammatory drugs ; ocular drug delivery ; Pharmacy ; Thin films</subject><ispartof>Drug delivery, 2019-01, Vol.26 (1), p.481-489</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2019 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-2dd0b9f723b5637a209b1a63fcffcdd796c86d8270e90d36c66925edca99b3b33</citedby><cites>FETCH-LOGICAL-c562t-2dd0b9f723b5637a209b1a63fcffcdd796c86d8270e90d36c66925edca99b3b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461112/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461112/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,27502,27924,27925,53791,53793,59143,59144</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30957571$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Mengshuang</creatorcontrib><creatorcontrib>Lan, Jie</creatorcontrib><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Xin, Meng</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Lu, Xiaohong</creatorcontrib><creatorcontrib>Zhuang, Zengfang</creatorcontrib><creatorcontrib>Wu, Xianggen</creatorcontrib><title>Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery</title><title>Drug delivery</title><addtitle>Drug Deliv</addtitle><description>Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action and reduce side effects.
Methods: Diclofenac-loaded Rb1 micelles (Rb1-Dic micelles) were formulated, optimized, and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vivo corneal permeation, and in vivo anti-inflammatory efficacy.
Results: Rb1 self-assembled into micelles with ultra-small particle size (<8 nm) in a homogeneous distribution state (polydispersity index [PDI] < 0.3). Diclofenac was highly encapsulated into the micelles according to the weight ratios of Rb1 to diclofenac. The ophthalmic solution of Rb1-Dic micelle was simple to prepare. Rb1 had good cellular tolerance, and it also improved the cellular tolerance of the encapsulated diclofenac. Rb1-Dic micelles also showed non-irritants to the rabbit eyes. The use of Rb1 micelles significantly improved the in vivo corneal permeation as well as the anti-inflammatory efficacy of diclofenac when compared to commercial diclofenac eye drops.
Conclusion: Rb1 micelle formulations have great potential as a novel ocular drug delivery system to improve the bioavailability of drugs such as diclofenac.</description><subject>Bioavailability</subject><subject>Chemical engineering</subject><subject>Cornea</subject><subject>Cytotoxicity</subject><subject>diclofenac</subject><subject>Drug delivery systems</subject><subject>Ginsenoside Rb1</subject><subject>Hospitals</subject><subject>Laboratory animals</subject><subject>micelle</subject><subject>Nanomaterials</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>ocular drug delivery</subject><subject>Pharmacy</subject><subject>Thin films</subject><issn>1071-7544</issn><issn>1521-0464</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp9kV1rFDEUhgdRbK3-BCXg9awn3zNeiKVoWygKotchX7NmyU7WZGZl_70Zd1vsjTdJSJ48Jydv07zGsMLQwTsMEkvO2IoA7ldYAICUT5pzzAlugQn2tK4r0y7QWfOilE1FOkz48-aMQs8ll_i8Gb6kvY9ojlPWbdnqGNE2WB-jL8jo4h1KI1qHsfgxleA8-mbwe6TRLk1-nIKOaNRj2kU9DSlvUR1QsnPUGbk8r5HzMex9Prxsng06Fv_qNF80Pz5_-n510959vb69urxrLRdkaolzYPpBEmq4oFIT6A3Wgg52GKxzshe2E64jEnwPjgorRE-4d1b3vaGG0ovm9uh1SW_ULoetzgeVdFB_N1JeK52nYKNX1JD6Gw6oEZwtCuo7oIwLxoAZLKrrw9G1m822ArXfrOMj6eOTMfxU67RXggmMMamCtydBTr9mXya1SXMea_-KUI6BAaZLGX6kbE6lZD88VMCglqjVfdRqiVqdoq733vz7vIdb99lW4OMRCOOSjf6dcnRq0oeY8pD1aENR9P81_gD_Abki</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Li, Mengshuang</creator><creator>Lan, Jie</creator><creator>Li, Xuefei</creator><creator>Xin, Meng</creator><creator>Wang, Hui</creator><creator>Zhang, Fan</creator><creator>Lu, Xiaohong</creator><creator>Zhuang, Zengfang</creator><creator>Wu, Xianggen</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20190101</creationdate><title>Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery</title><author>Li, Mengshuang ; Lan, Jie ; Li, Xuefei ; Xin, Meng ; Wang, Hui ; Zhang, Fan ; Lu, Xiaohong ; Zhuang, Zengfang ; Wu, Xianggen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-2dd0b9f723b5637a209b1a63fcffcdd796c86d8270e90d36c66925edca99b3b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bioavailability</topic><topic>Chemical engineering</topic><topic>Cornea</topic><topic>Cytotoxicity</topic><topic>diclofenac</topic><topic>Drug delivery systems</topic><topic>Ginsenoside Rb1</topic><topic>Hospitals</topic><topic>Laboratory animals</topic><topic>micelle</topic><topic>Nanomaterials</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>ocular drug delivery</topic><topic>Pharmacy</topic><topic>Thin films</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Mengshuang</creatorcontrib><creatorcontrib>Lan, Jie</creatorcontrib><creatorcontrib>Li, Xuefei</creatorcontrib><creatorcontrib>Xin, Meng</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Zhang, Fan</creatorcontrib><creatorcontrib>Lu, Xiaohong</creatorcontrib><creatorcontrib>Zhuang, Zengfang</creatorcontrib><creatorcontrib>Wu, Xianggen</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Drug delivery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Mengshuang</au><au>Lan, Jie</au><au>Li, Xuefei</au><au>Xin, Meng</au><au>Wang, Hui</au><au>Zhang, Fan</au><au>Lu, Xiaohong</au><au>Zhuang, Zengfang</au><au>Wu, Xianggen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery</atitle><jtitle>Drug delivery</jtitle><addtitle>Drug Deliv</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>26</volume><issue>1</issue><spage>481</spage><epage>489</epage><pages>481-489</pages><issn>1071-7544</issn><eissn>1521-0464</eissn><abstract>Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might strengthen the drug's therapeutic action and reduce side effects.
Methods: Diclofenac-loaded Rb1 micelles (Rb1-Dic micelles) were formulated, optimized, and then further evaluated for in vitro cytotoxicity/in vivo ocular irritation, in vivo corneal permeation, and in vivo anti-inflammatory efficacy.
Results: Rb1 self-assembled into micelles with ultra-small particle size (<8 nm) in a homogeneous distribution state (polydispersity index [PDI] < 0.3). Diclofenac was highly encapsulated into the micelles according to the weight ratios of Rb1 to diclofenac. The ophthalmic solution of Rb1-Dic micelle was simple to prepare. Rb1 had good cellular tolerance, and it also improved the cellular tolerance of the encapsulated diclofenac. Rb1-Dic micelles also showed non-irritants to the rabbit eyes. The use of Rb1 micelles significantly improved the in vivo corneal permeation as well as the anti-inflammatory efficacy of diclofenac when compared to commercial diclofenac eye drops.
Conclusion: Rb1 micelle formulations have great potential as a novel ocular drug delivery system to improve the bioavailability of drugs such as diclofenac.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30957571</pmid><doi>10.1080/10717544.2019.1600077</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-7544 |
| ispartof | Drug delivery, 2019-01, Vol.26 (1), p.481-489 |
| issn | 1071-7544 1521-0464 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6461112 |
| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Bioavailability Chemical engineering Cornea Cytotoxicity diclofenac Drug delivery systems Ginsenoside Rb1 Hospitals Laboratory animals micelle Nanomaterials Nonsteroidal anti-inflammatory drugs ocular drug delivery Pharmacy Thin films |
| title | Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T20%3A24%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20ultra-small%20micelles%20based%20on%20ginsenoside%20Rb1:%20a%20potential%20nanoplatform%20for%20ocular%20drug%20delivery&rft.jtitle=Drug%20delivery&rft.au=Li,%20Mengshuang&rft.date=2019-01-01&rft.volume=26&rft.issue=1&rft.spage=481&rft.epage=489&rft.pages=481-489&rft.issn=1071-7544&rft.eissn=1521-0464&rft_id=info:doi/10.1080/10717544.2019.1600077&rft_dat=%3Cproquest_pubme%3E2351040136%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2351040136&rft_id=info:pmid/30957571&rft_doaj_id=oai_doaj_org_article_3b2812d03b654edca3e8034564404b16&rfr_iscdi=true |