Integrating endocannabinoid signaling in the regulation of anxiety and depression
Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism’s long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of th...
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| Veröffentlicht in: | Acta pharmacologica Sinica 2019-03, Vol.40 (3), p.336-341 |
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| container_title | Acta pharmacologica Sinica |
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| creator | Yin, An-qi Wang, Feng Zhang, Xia |
| description | Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism’s long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation. |
| doi_str_mv | 10.1038/s41401-018-0051-5 |
| format | Article |
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Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation.</description><identifier>ISSN: 1671-4083</identifier><identifier>EISSN: 1745-7254</identifier><identifier>DOI: 10.1038/s41401-018-0051-5</identifier><identifier>PMID: 30002489</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Animals ; Anti-Anxiety Agents - therapeutic use ; Anxiety ; Anxiety - drug therapy ; Anxiety - physiopathology ; Arachidonic Acids - physiology ; Binding sites ; Biomedical and Life Sciences ; Biomedicine ; Brain - drug effects ; Brain - metabolism ; Brain research ; Depression ; Depression - drug therapy ; Depression - physiopathology ; Endocannabinoids - physiology ; Enzyme Inhibitors - therapeutic use ; Enzymes ; Fatty acids ; Glycerides - physiology ; Homeostasis ; Humans ; Immunology ; Internal Medicine ; Marijuana ; Medical Microbiology ; Membranes ; Mental depression ; Mental disorders ; Nervous system ; Neural networks ; Neurotransmitters ; Pharmacology/Toxicology ; Polyunsaturated Alkamides ; Receptor, Cannabinoid, CB1 - metabolism ; Receptor, Cannabinoid, CB2 - metabolism ; Review ; Review Article ; Signal Transduction - physiology ; Stress ; Stress response ; Vaccine ; Viability</subject><ispartof>Acta pharmacologica Sinica, 2019-03, Vol.40 (3), p.336-341</ispartof><rights>CPS and SIMM 2018</rights><rights>Copyright Nature Publishing Group Mar 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-89889adc6488482b6bad80be49c403f014db60ff2b9f0bbfebc0f452f15bf41a3</citedby><cites>FETCH-LOGICAL-c470t-89889adc6488482b6bad80be49c403f014db60ff2b9f0bbfebc0f452f15bf41a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460364/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460364/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30002489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, An-qi</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Zhang, Xia</creatorcontrib><title>Integrating endocannabinoid signaling in the regulation of anxiety and depression</title><title>Acta pharmacologica Sinica</title><addtitle>Acta Pharmacol Sin</addtitle><addtitle>Acta Pharmacol Sin</addtitle><description>Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism’s long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation.</description><subject>Animals</subject><subject>Anti-Anxiety Agents - therapeutic use</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety - physiopathology</subject><subject>Arachidonic Acids - physiology</subject><subject>Binding sites</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain research</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Endocannabinoids - physiology</subject><subject>Enzyme Inhibitors - therapeutic use</subject><subject>Enzymes</subject><subject>Fatty acids</subject><subject>Glycerides - physiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Marijuana</subject><subject>Medical Microbiology</subject><subject>Membranes</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Nervous system</subject><subject>Neural networks</subject><subject>Neurotransmitters</subject><subject>Pharmacology/Toxicology</subject><subject>Polyunsaturated Alkamides</subject><subject>Receptor, Cannabinoid, CB1 - metabolism</subject><subject>Receptor, Cannabinoid, CB2 - metabolism</subject><subject>Review</subject><subject>Review Article</subject><subject>Signal Transduction - physiology</subject><subject>Stress</subject><subject>Stress response</subject><subject>Vaccine</subject><subject>Viability</subject><issn>1671-4083</issn><issn>1745-7254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFr3DAQhUVJaJJtf0AuwZBLL25nbNmWL4GwpGkgUALJWUj2yKvglTaSHZJ_Xy2bbptCTyN43zxJ7zF2ivAVoRTfIkcOmAOKHKDCvPrAjrHhVd4UFT9I57rBnIMoj9hJjI8AZVFi-5EdlQBQcNEes7sbN9EQ1GTdkJHrfaecU9o6b_ss2sGpcatYl00rygIN85hY7zJvMuVeLE2vafZZT5tAMSblEzs0aoz0-W0u2MP3q_vlj_z25_XN8vI273gDUy5aIVrVdzUXgotC11r1AjTxtuNQGkDe6xqMKXRrQGtDugPDq8JgpQ1HVS7Yxc53M-s19R25KahRboJdq_AqvbLyveLsSg7-Wda8hrLmyeDLm0HwTzPFSa5t7GgclSM_R1lAk0JCSFEv2Pk_6KOfQ8omUSiwaURTbSncUV3wMQYy-8cgyG1hcleYTIXJbWGySjtnf_9iv_G7oQQUOyAmyQ0U_lz9f9dfN9iicA</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Yin, An-qi</creator><creator>Wang, Feng</creator><creator>Zhang, Xia</creator><general>Springer Singapore</general><general>Nature Publishing Group</general><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190301</creationdate><title>Integrating endocannabinoid signaling in the regulation of anxiety and depression</title><author>Yin, An-qi ; Wang, Feng ; Zhang, Xia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-89889adc6488482b6bad80be49c403f014db60ff2b9f0bbfebc0f452f15bf41a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Anti-Anxiety Agents - therapeutic use</topic><topic>Anxiety</topic><topic>Anxiety - drug therapy</topic><topic>Anxiety - physiopathology</topic><topic>Arachidonic Acids - physiology</topic><topic>Binding sites</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain research</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - physiopathology</topic><topic>Endocannabinoids - physiology</topic><topic>Enzyme Inhibitors - therapeutic use</topic><topic>Enzymes</topic><topic>Fatty acids</topic><topic>Glycerides - physiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Marijuana</topic><topic>Medical Microbiology</topic><topic>Membranes</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Nervous system</topic><topic>Neural networks</topic><topic>Neurotransmitters</topic><topic>Pharmacology/Toxicology</topic><topic>Polyunsaturated Alkamides</topic><topic>Receptor, Cannabinoid, CB1 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta pharmacologica Sinica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, An-qi</au><au>Wang, Feng</au><au>Zhang, Xia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integrating endocannabinoid signaling in the regulation of anxiety and depression</atitle><jtitle>Acta pharmacologica Sinica</jtitle><stitle>Acta Pharmacol Sin</stitle><addtitle>Acta Pharmacol Sin</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>40</volume><issue>3</issue><spage>336</spage><epage>341</epage><pages>336-341</pages><issn>1671-4083</issn><eissn>1745-7254</eissn><abstract>Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism’s long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. An understanding of the underlying neural cell populations and neural circuit regulation will enable the development of therapeutic strategies to mitigate behavioral maladaptation and provide insight into the influence of eCB on the neural circuits involved in anxiety and depression. This review focuses on recent evidence that has added a new layer of complexity to the idea of targeting the eCB system for therapeutic benefits in neuropsychiatric disease and on the future research direction of neural circuit modulation.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>30002489</pmid><doi>10.1038/s41401-018-0051-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Anti-Anxiety Agents - therapeutic use Anxiety Anxiety - drug therapy Anxiety - physiopathology Arachidonic Acids - physiology Binding sites Biomedical and Life Sciences Biomedicine Brain - drug effects Brain - metabolism Brain research Depression Depression - drug therapy Depression - physiopathology Endocannabinoids - physiology Enzyme Inhibitors - therapeutic use Enzymes Fatty acids Glycerides - physiology Homeostasis Humans Immunology Internal Medicine Marijuana Medical Microbiology Membranes Mental depression Mental disorders Nervous system Neural networks Neurotransmitters Pharmacology/Toxicology Polyunsaturated Alkamides Receptor, Cannabinoid, CB1 - metabolism Receptor, Cannabinoid, CB2 - metabolism Review Review Article Signal Transduction - physiology Stress Stress response Vaccine Viability |
| title | Integrating endocannabinoid signaling in the regulation of anxiety and depression |
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