Glutathione prevents chronic oscillating glucose intake-induced β-cell dedifferentiation and failure

Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes. A strong positive correlation between sugar consumption and diabetic incidence is revealed, but the underlying mechanisms remain obscure. Here we show that oral intake of long...

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Veröffentlicht in:	Cell death & disease 2019-04, Vol.10 (4), p.321, Article 321
Hauptverfasser:	Zhang, Jitai, An, Hui, Ni, Kaidi, Chen, Bin, Li, Hui, Li, Yanqin, Sheng, Guilian, Zhou, Chuanzan, Xie, Mengzhen, Chen, Saijing, Zhou, Tong, Yang, Gaoxiong, Chen, Xiufang, Wu, Gaojun, Jin, Shengwei, Li, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/2 13/31 13/51 13/95 14/19 14/63 38/77 631/80/86 692/699/2743/2815 82/80 96 Animals Antibodies Antioxidants Antioxidants - metabolism Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Blood Glucose - drug effects Blood Glucose - metabolism Cell Biology Cell Culture Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Dedifferentiation - drug effects Cell Dedifferentiation - genetics Diabetes mellitus Female Forkhead protein FOXO1 protein Glucose Glucose - metabolism Glucose - toxicity Glucose Intolerance - metabolism Glucose tolerance Glutathione Glutathione - pharmacology Homeostasis Immunology Insulin Insulin - metabolism Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Intolerance Life Sciences Metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Pancreas - drug effects Pancreas - metabolism Prediabetic State - metabolism Rats Rats, Sprague-Dawley Reactive oxygen species Reactive Oxygen Species - metabolism Sugar Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Thioredoxin
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