Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

Although the role of urea in urine concentration is known, the effect of urea handling by the urea transporters (UTs), UT-A1 and UT-A3, on sodium balance remains elusive. Serum and urinary sodium concentration is similar between wild-type mice (WT) and UT-A3 null (UT-A3 KO) mice; however, mice lacki...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2019-03, Vol.316 (3), p.F539-F549
Hauptverfasser:	Rogers, Richard T, Sun, Michael A, Yue, Qiang, Bao, Hui-Fang, Sands, Jeff M, Blount, Mitsi A, Eaton, Douglas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Epithelial Sodium Channels - metabolism Ion Transport - physiology Kidney Concentrating Ability - physiology Kidney Medulla - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice Mice, Knockout Nitric Oxide - metabolism Sodium - metabolism Urea Transporters
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