SMYD2-OE promotes oxaliplatin resistance in colon cancer through MDR1/P-glycoprotein via MEK/ERK/AP1 pathway

SET and MYND domain-containing protein 2 (SMYD2-OE) plays an important role in cancer development through methylating histone and non-histone proteins. However, little is known about the relevance of SMYD2-OE in colon cancer. Moreover, oxaliplatin (L-OHP) is applied as first line for colon cancer ch...

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Veröffentlicht in:	OncoTargets and therapy 2019-01, Vol.12, p.2585-2594
Hauptverfasser:	Ren, Hailiang, Wang, Zheng, Chen, Yao, Liu, Yanjun, Zhang, Shu, Zhang, Tongtong, Li, Yuntao
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast cancer Cancer therapies Cell cycle Cell growth Chemotherapy Colorectal cancer Deoxyribonucleic acid DNA DNA methylation Glycoproteins Hospitals Leukemia Medical prognosis Original Research Patients Pediatrics Proteins Surgery
Online-Zugang:	Volltext
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