Selective Roles of Vertebrate PCF11 in Premature and Full-Length Transcript Termination

The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient termination. A key player in this process is the cleavage and polyadenylation (CPA) factor PCF11, which directly binds to the Pol II C-terminal domain and dismantles elongating Pol II from DNA in vitro. We demonstrat...

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Veröffentlicht in:	Molecular cell 2019-04, Vol.74 (1), p.158-172.e9
Hauptverfasser:	Kamieniarz-Gdula, Kinga, Gdula, Michal R., Panser, Karin, Nojima, Takayuki, Monks, Joan, Wiśniewski, Jacek R., Riepsaame, Joey, Brockdorff, Neil, Pauli, Andrea, Proudfoot, Nick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	alternative polyadenylation Animals Animals, Genetically Modified attenuation autoregulation Binding Sites Gene Expression Regulation, Developmental HeLa Cells human Humans mRNA Cleavage and Polyadenylation Factors - genetics mRNA Cleavage and Polyadenylation Factors - metabolism Mutation PCF11 Polyadenylation premature termination Protein Binding regulation of gene expression RNA 3′ processing RNA Cleavage RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA, Messenger - biosynthesis RNA, Messenger - genetics transcription termination Transcription Termination, Genetic zebrafish Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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