Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood
Abstract Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are ass...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2019-05, Vol.29 (5), p.1866-1874 |
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| creator | Albaugh, Matthew D Ivanova, Masha Chaarani, Bader Orr, Catherine Allgaier, Nicholas Althoff, Robert R D’ Alberto, Nicholas Hudson, Kelsey Mackey, Scott Spechler, Philip A Banaschewski, Tobias Brühl, Rüdiger Bokde, Arun L W Bromberg, Uli Büchel, Christian Cattrell, Anna Conrod, Patricia J Desrivières, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Goodman, Robert Gowland, Penny Grimmer, Yvonne Heinz, Andreas Kappel, Viola Martinot, Jean-Luc Martinot, Marie-Laure Paillère Nees, Frauke Papadopoulos Orfanos, Dimitri Penttilä, Jani Poustka, Luise Paus, Tomáš Smolka, Michael N Struve, Maren Walter, Henrik Whelan, Robert Schumann, Gunter Garavan, Hugh Potter, Alexandra S |
| description | Abstract
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = −0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms. |
| doi_str_mv | 10.1093/cercor/bhy066 |
| format | Article |
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Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = −0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.</description><identifier>ISSN: 1047-3211</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhy066</identifier><identifier>PMID: 29912404</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Adult ; Attention - physiology ; Attention Deficit Disorder with Hyperactivity - diagnostic imaging ; Attention Deficit Disorder with Hyperactivity - pathology ; Female ; Humans ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Organ Size ; Original ; Prefrontal Cortex - diagnostic imaging ; Prefrontal Cortex - pathology ; Psychomotor Agitation - diagnostic imaging ; Psychomotor Agitation - pathology ; Young Adult</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2019-05, Vol.29 (5), p.1866-1874</ispartof><rights>The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-bf022a18527f93aee3cdbb02162d3a047cff9f6eaa38fd2ec19e15727066e5773</citedby><cites>FETCH-LOGICAL-c420t-bf022a18527f93aee3cdbb02162d3a047cff9f6eaa38fd2ec19e15727066e5773</cites><orcidid>0000-0001-9360-6623 ; 0000-0002-9120-7060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,1586,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29912404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albaugh, Matthew D</creatorcontrib><creatorcontrib>Ivanova, Masha</creatorcontrib><creatorcontrib>Chaarani, Bader</creatorcontrib><creatorcontrib>Orr, Catherine</creatorcontrib><creatorcontrib>Allgaier, Nicholas</creatorcontrib><creatorcontrib>Althoff, Robert R</creatorcontrib><creatorcontrib>D’ Alberto, Nicholas</creatorcontrib><creatorcontrib>Hudson, Kelsey</creatorcontrib><creatorcontrib>Mackey, Scott</creatorcontrib><creatorcontrib>Spechler, Philip A</creatorcontrib><creatorcontrib>Banaschewski, Tobias</creatorcontrib><creatorcontrib>Brühl, Rüdiger</creatorcontrib><creatorcontrib>Bokde, Arun L W</creatorcontrib><creatorcontrib>Bromberg, Uli</creatorcontrib><creatorcontrib>Büchel, Christian</creatorcontrib><creatorcontrib>Cattrell, Anna</creatorcontrib><creatorcontrib>Conrod, Patricia J</creatorcontrib><creatorcontrib>Desrivières, Sylvane</creatorcontrib><creatorcontrib>Flor, Herta</creatorcontrib><creatorcontrib>Frouin, Vincent</creatorcontrib><creatorcontrib>Gallinat, Jürgen</creatorcontrib><creatorcontrib>Goodman, Robert</creatorcontrib><creatorcontrib>Gowland, Penny</creatorcontrib><creatorcontrib>Grimmer, Yvonne</creatorcontrib><creatorcontrib>Heinz, Andreas</creatorcontrib><creatorcontrib>Kappel, Viola</creatorcontrib><creatorcontrib>Martinot, Jean-Luc</creatorcontrib><creatorcontrib>Martinot, Marie-Laure Paillère</creatorcontrib><creatorcontrib>Nees, Frauke</creatorcontrib><creatorcontrib>Papadopoulos Orfanos, Dimitri</creatorcontrib><creatorcontrib>Penttilä, Jani</creatorcontrib><creatorcontrib>Poustka, Luise</creatorcontrib><creatorcontrib>Paus, Tomáš</creatorcontrib><creatorcontrib>Smolka, Michael N</creatorcontrib><creatorcontrib>Struve, Maren</creatorcontrib><creatorcontrib>Walter, Henrik</creatorcontrib><creatorcontrib>Whelan, Robert</creatorcontrib><creatorcontrib>Schumann, Gunter</creatorcontrib><creatorcontrib>Garavan, Hugh</creatorcontrib><creatorcontrib>Potter, Alexandra S</creatorcontrib><title>Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = −0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Attention - physiology</subject><subject>Attention Deficit Disorder with Hyperactivity - diagnostic imaging</subject><subject>Attention Deficit Disorder with Hyperactivity - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Organ Size</subject><subject>Original</subject><subject>Prefrontal Cortex - diagnostic imaging</subject><subject>Prefrontal Cortex - pathology</subject><subject>Psychomotor Agitation - diagnostic imaging</subject><subject>Psychomotor Agitation - pathology</subject><subject>Young Adult</subject><issn>1047-3211</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFLwzAYxYMobk6PXqVHL3VJ2qbNRRiibjBQUHcNafrVVdqmJulg_70ZnVNPnvIgv7zve3kIXRJ8QzCPpgqM0maar7eYsSM0JjHDISWcH3uN4zSMKCEjdGbtB8YkpQk9RSPKOaExjseoWEHrjG6gqGQdPBsojW6dlytd9w0EVRvMCl2DVdAq2AFFpZwN5tsOjFSu2sB00UrnvI3Xwcu26Zxu7PCwr91a6-IcnZSytnCxPyfo7eH-9W4eLp8eF3ezZahiil2Yl5hSSbKEpiWPJECkijzHlDBaRNJnUWXJSwZSRllZUFCEA0lSmvrkkKRpNEG3g2_X5z6R2kWTtehM1UizFVpW4u9NW63Fu94IFicZx8wbXO8NjP7swTrRVD55XcsWdG8FxQlLGcl45tFwQJXR1vp_O4whWOyaEUMzYmjG81e_dzvQ31X8zNZ994_XF7OOnWA</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Albaugh, Matthew D</creator><creator>Ivanova, Masha</creator><creator>Chaarani, Bader</creator><creator>Orr, Catherine</creator><creator>Allgaier, Nicholas</creator><creator>Althoff, Robert R</creator><creator>D’ Alberto, Nicholas</creator><creator>Hudson, Kelsey</creator><creator>Mackey, Scott</creator><creator>Spechler, Philip A</creator><creator>Banaschewski, Tobias</creator><creator>Brühl, Rüdiger</creator><creator>Bokde, Arun L W</creator><creator>Bromberg, Uli</creator><creator>Büchel, Christian</creator><creator>Cattrell, Anna</creator><creator>Conrod, Patricia J</creator><creator>Desrivières, Sylvane</creator><creator>Flor, Herta</creator><creator>Frouin, Vincent</creator><creator>Gallinat, Jürgen</creator><creator>Goodman, Robert</creator><creator>Gowland, Penny</creator><creator>Grimmer, Yvonne</creator><creator>Heinz, Andreas</creator><creator>Kappel, Viola</creator><creator>Martinot, Jean-Luc</creator><creator>Martinot, Marie-Laure Paillère</creator><creator>Nees, Frauke</creator><creator>Papadopoulos Orfanos, Dimitri</creator><creator>Penttilä, Jani</creator><creator>Poustka, Luise</creator><creator>Paus, Tomáš</creator><creator>Smolka, Michael N</creator><creator>Struve, Maren</creator><creator>Walter, Henrik</creator><creator>Whelan, Robert</creator><creator>Schumann, Gunter</creator><creator>Garavan, Hugh</creator><creator>Potter, Alexandra S</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9360-6623</orcidid><orcidid>https://orcid.org/0000-0002-9120-7060</orcidid></search><sort><creationdate>20190501</creationdate><title>Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood</title><author>Albaugh, Matthew D ; Ivanova, Masha ; Chaarani, Bader ; Orr, Catherine ; Allgaier, Nicholas ; Althoff, Robert R ; D’ Alberto, Nicholas ; Hudson, Kelsey ; Mackey, Scott ; Spechler, Philip A ; Banaschewski, Tobias ; Brühl, Rüdiger ; Bokde, Arun L W ; Bromberg, Uli ; Büchel, Christian ; Cattrell, Anna ; Conrod, Patricia J ; Desrivières, Sylvane ; Flor, Herta ; Frouin, Vincent ; Gallinat, Jürgen ; Goodman, Robert ; Gowland, Penny ; Grimmer, Yvonne ; Heinz, Andreas ; Kappel, Viola ; Martinot, Jean-Luc ; Martinot, Marie-Laure Paillère ; Nees, Frauke ; Papadopoulos Orfanos, Dimitri ; Penttilä, Jani ; Poustka, Luise ; Paus, Tomáš ; Smolka, Michael N ; Struve, Maren ; Walter, Henrik ; Whelan, Robert ; Schumann, Gunter ; Garavan, Hugh ; Potter, Alexandra S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-bf022a18527f93aee3cdbb02162d3a047cff9f6eaa38fd2ec19e15727066e5773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Attention - 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Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant ratings of hyperactive/inattentive symptoms are associated with ventromedial prefrontal cortex (vmPFC) structure. Herein, we investigate the degree to which vmPFC structure during adolescence predicts hyperactive/inattentive symptomatology at 5-year follow-up. Structural equation modeling was used to test the extent to which adolescent vmPFC volume predicts hyperactive/inattentive symptomatology 5 years later in early adulthood. 1104 participants (M = 14.52 years, standard deviation = 0.42; 583 females) possessed hyperactive/inattentive symptom data at 5-year follow-up, as well as quality controlled neuroimaging data and complete psychometric data at baseline. Self-reports of hyperactive/inattentive symptomatology were obtained during adolescence and at 5-year follow-up using the Strengths and Difficulties Questionnaire (SDQ). At baseline and 5-year follow-up, a hyperactive/inattentive latent variable was derived from items on the SDQ. Baseline vmPFC volume predicted adult hyperactive/inattentive symptomatology (standardized coefficient = −0.274, P < 0.001) while controlling for baseline hyperactive/inattentive symptomatology. These results are the first to reveal relations between adolescent brain structure and adult hyperactive/inattentive symptomatology, and suggest that early structural development of the vmPFC may be consequential for the subsequent expression of hyperactive/inattentive symptoms.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>29912404</pmid><doi>10.1093/cercor/bhy066</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9360-6623</orcidid><orcidid>https://orcid.org/0000-0002-9120-7060</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1047-3211 |
| ispartof | Cerebral cortex (New York, N.Y. 1991), 2019-05, Vol.29 (5), p.1866-1874 |
| issn | 1047-3211 1460-2199 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6458906 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Attention - physiology Attention Deficit Disorder with Hyperactivity - diagnostic imaging Attention Deficit Disorder with Hyperactivity - pathology Female Humans Longitudinal Studies Magnetic Resonance Imaging Male Organ Size Original Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - pathology Psychomotor Agitation - diagnostic imaging Psychomotor Agitation - pathology Young Adult |
| title | Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T08%3A08%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ventromedial%20Prefrontal%20Volume%20in%20Adolescence%20Predicts%20Hyperactive/Inattentive%20Symptoms%20in%20Adulthood&rft.jtitle=Cerebral%20cortex%20(New%20York,%20N.Y.%201991)&rft.au=Albaugh,%20Matthew%20D&rft.date=2019-05-01&rft.volume=29&rft.issue=5&rft.spage=1866&rft.epage=1874&rft.pages=1866-1874&rft.issn=1047-3211&rft.eissn=1460-2199&rft_id=info:doi/10.1093/cercor/bhy066&rft_dat=%3Cproquest_pubme%3E2056761898%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2056761898&rft_id=info:pmid/29912404&rft_oup_id=10.1093/cercor/bhy066&rfr_iscdi=true |