EPPS treatment attenuates traumatic brain injury in mice by reducing Aβ burden and ameliorating neuronal autophagic flux

Beta-amyloid (Aβ) burden and impaired neuronal autophagy contribute to secondary brain injury after traumatic brain injury (TBI). 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS) treatment has been reported to reduce Aβ aggregation and rescue behavioral deficits in Alzheimer's diseas...

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Veröffentlicht in:	Experimental neurology 2019-04, Vol.314, p.20-33
Hauptverfasser:	Anthony Jalin, Angela Melinda A., Jin, Rong, Wang, Min, Li, Guohong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Animals Apoptosis - drug effects Autophagy Autophagy - drug effects Axonal injury Axons - drug effects Axons - pathology Beta-amyloid Brain Chemistry - drug effects Brain Injuries, Traumatic - drug therapy Brain Injuries, Traumatic - pathology Brain Injuries, Traumatic - psychology Cathepsin C - metabolism Cognition - drug effects Hippocampus - pathology Male Mice Mice, Inbred C57BL Neuroprotection Neuroprotective Agents - therapeutic use Piperazines - therapeutic use Psychomotor Performance - drug effects Synapses - drug effects Synapses - pathology Traumatic brain injury
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