Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study
Urinary tract infection (UTI) and preeclampsia are common among pregnant women and are associated with adverse maternal-fetal and neonatal outcomes. Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting...
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| Veröffentlicht in: | BioMed research international 2019-01, Vol.2019 (2019), p.1-8 |
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| description | Urinary tract infection (UTI) and preeclampsia are common among pregnant women and are associated with adverse maternal-fetal and neonatal outcomes. Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting the adverse outcomes. A 1:2 matched case-control study (by age and gravidity) involving 131 pregnant women with preeclampsia (cases) and 262 without preeclampsia (controls) was conducted. Sociodemographic and clinical information was collected using a questionnaire. Midstream urine samples were collected during admission for culture and antimicrobial susceptibility testing (AST). Out of 393 pregnant women enrolled, 110 (28.0%), 95% CI: 23.8%-32.7%, had significant bacteriuria [cases: 50.4% (66/131) and control: 16.8% (44/262)]. Pregnant women with preeclampsia had 7.7 odds of having significant bacteriuria than those without preeclampsia [OR=7.7, 95% CI (4.11-14.49); p-value |
| doi_str_mv | 10.1155/2019/3937812 |
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Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting the adverse outcomes. A 1:2 matched case-control study (by age and gravidity) involving 131 pregnant women with preeclampsia (cases) and 262 without preeclampsia (controls) was conducted. Sociodemographic and clinical information was collected using a questionnaire. Midstream urine samples were collected during admission for culture and antimicrobial susceptibility testing (AST). Out of 393 pregnant women enrolled, 110 (28.0%), 95% CI: 23.8%-32.7%, had significant bacteriuria [cases: 50.4% (66/131) and control: 16.8% (44/262)]. Pregnant women with preeclampsia had 7.7 odds of having significant bacteriuria than those without preeclampsia [OR=7.7, 95% CI (4.11-14.49); p-value <0.001]. Escherichia coli, 50 (45.5%), and Klebsiella spp., 25 (23.6%), predominated, and resistance to gentamicin, ceftriaxone, and piperacillin-tazobactam ranged from 9.0% to 29.0% in these dominant species. Extended spectrum beta lactamases (ESBL) production in Escherichia coli and Klebsiella spp. was 18.0% (9/50) and 15.4% (4/26), respectively. Routine urine culture and AST among pregnant women with preeclampsia should be introduced in the antenatal clinics to ensure prompt management. Delineation of maternal-fetal and neonatal outcomes among pregnant women with preeclampsia and UTIs would be of interest in future studies.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2019/3937812</identifier><identifier>PMID: 31032344</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age ; Bacteria ; Bacteriuria ; Beta lactamases ; Blood pressure ; Ceftriaxone ; Computer software industry ; Culture ; Dominant species ; E coli ; Escherichia coli ; Fetuses ; Gentamicin ; Gynecology ; Hospitals ; Hypertension ; Imipenem ; Infections ; International economic relations ; Klebsiella ; Laboratories ; Neonates ; Obstetrics ; Pathogenesis ; Piperacillin ; Piperacillin-tazobactam ; Population ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnant women ; Reproductive health ; Sample size ; Software ; Tazobactam ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urine ; Urogenital system ; Womens health</subject><ispartof>BioMed research international, 2019-01, Vol.2019 (2019), p.1-8</ispartof><rights>Copyright © 2019 Joshua Kaduma et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Joshua Kaduma et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Joshua Kaduma et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-b68a25e23739cc4d703f27da0c565de32b7af0fa37f8bf7d27ff5a5334d27c6a3</citedby><cites>FETCH-LOGICAL-c499t-b68a25e23739cc4d703f27da0c565de32b7af0fa37f8bf7d27ff5a5334d27c6a3</cites><orcidid>0000-0002-7526-6271 ; 0000-0003-2420-5329 ; 0000-0003-3511-2523</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457296/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457296/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31032344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Girardi, Guillermina</contributor><contributor>Guillermina Girardi</contributor><creatorcontrib>Mshana, Stephen E.</creatorcontrib><creatorcontrib>Mushi, Martha F.</creatorcontrib><creatorcontrib>Mujuni, Fridolin</creatorcontrib><creatorcontrib>Kirita, Richard</creatorcontrib><creatorcontrib>Chuma, Clotilda</creatorcontrib><creatorcontrib>Seni, Jeremiah</creatorcontrib><creatorcontrib>Kaduma, Joshua</creatorcontrib><creatorcontrib>van der Meer, Frank</creatorcontrib><title>Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Urinary tract infection (UTI) and preeclampsia are common among pregnant women and are associated with adverse maternal-fetal and neonatal outcomes. Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting the adverse outcomes. A 1:2 matched case-control study (by age and gravidity) involving 131 pregnant women with preeclampsia (cases) and 262 without preeclampsia (controls) was conducted. Sociodemographic and clinical information was collected using a questionnaire. Midstream urine samples were collected during admission for culture and antimicrobial susceptibility testing (AST). Out of 393 pregnant women enrolled, 110 (28.0%), 95% CI: 23.8%-32.7%, had significant bacteriuria [cases: 50.4% (66/131) and control: 16.8% (44/262)]. Pregnant women with preeclampsia had 7.7 odds of having significant bacteriuria than those without preeclampsia [OR=7.7, 95% CI (4.11-14.49); p-value <0.001]. Escherichia coli, 50 (45.5%), and Klebsiella spp., 25 (23.6%), predominated, and resistance to gentamicin, ceftriaxone, and piperacillin-tazobactam ranged from 9.0% to 29.0% in these dominant species. Extended spectrum beta lactamases (ESBL) production in Escherichia coli and Klebsiella spp. was 18.0% (9/50) and 15.4% (4/26), respectively. Routine urine culture and AST among pregnant women with preeclampsia should be introduced in the antenatal clinics to ensure prompt management. Delineation of maternal-fetal and neonatal outcomes among pregnant women with preeclampsia and UTIs would be of interest in future studies.</description><subject>Age</subject><subject>Bacteria</subject><subject>Bacteriuria</subject><subject>Beta lactamases</subject><subject>Blood pressure</subject><subject>Ceftriaxone</subject><subject>Computer software industry</subject><subject>Culture</subject><subject>Dominant species</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Fetuses</subject><subject>Gentamicin</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Imipenem</subject><subject>Infections</subject><subject>International economic 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Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study</title><author>Mshana, Stephen E. ; Mushi, Martha F. ; Mujuni, Fridolin ; Kirita, Richard ; Chuma, Clotilda ; Seni, Jeremiah ; Kaduma, Joshua ; van der Meer, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-b68a25e23739cc4d703f27da0c565de32b7af0fa37f8bf7d27ff5a5334d27c6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age</topic><topic>Bacteria</topic><topic>Bacteriuria</topic><topic>Beta lactamases</topic><topic>Blood pressure</topic><topic>Ceftriaxone</topic><topic>Computer software industry</topic><topic>Culture</topic><topic>Dominant species</topic><topic>E coli</topic><topic>Escherichia 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E.</au><au>Mushi, Martha F.</au><au>Mujuni, Fridolin</au><au>Kirita, Richard</au><au>Chuma, Clotilda</au><au>Seni, Jeremiah</au><au>Kaduma, Joshua</au><au>van der Meer, Frank</au><au>Girardi, Guillermina</au><au>Guillermina Girardi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Urinary tract infection (UTI) and preeclampsia are common among pregnant women and are associated with adverse maternal-fetal and neonatal outcomes. Despite this, limited information exists on the association between UTIs and preeclampsia in Tanzania to guide specific management and thereby averting the adverse outcomes. A 1:2 matched case-control study (by age and gravidity) involving 131 pregnant women with preeclampsia (cases) and 262 without preeclampsia (controls) was conducted. Sociodemographic and clinical information was collected using a questionnaire. Midstream urine samples were collected during admission for culture and antimicrobial susceptibility testing (AST). Out of 393 pregnant women enrolled, 110 (28.0%), 95% CI: 23.8%-32.7%, had significant bacteriuria [cases: 50.4% (66/131) and control: 16.8% (44/262)]. Pregnant women with preeclampsia had 7.7 odds of having significant bacteriuria than those without preeclampsia [OR=7.7, 95% CI (4.11-14.49); p-value <0.001]. Escherichia coli, 50 (45.5%), and Klebsiella spp., 25 (23.6%), predominated, and resistance to gentamicin, ceftriaxone, and piperacillin-tazobactam ranged from 9.0% to 29.0% in these dominant species. Extended spectrum beta lactamases (ESBL) production in Escherichia coli and Klebsiella spp. was 18.0% (9/50) and 15.4% (4/26), respectively. Routine urine culture and AST among pregnant women with preeclampsia should be introduced in the antenatal clinics to ensure prompt management. Delineation of maternal-fetal and neonatal outcomes among pregnant women with preeclampsia and UTIs would be of interest in future studies.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31032344</pmid><doi>10.1155/2019/3937812</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7526-6271</orcidid><orcidid>https://orcid.org/0000-0003-2420-5329</orcidid><orcidid>https://orcid.org/0000-0003-3511-2523</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Bacteria Bacteriuria Beta lactamases Blood pressure Ceftriaxone Computer software industry Culture Dominant species E coli Escherichia coli Fetuses Gentamicin Gynecology Hospitals Hypertension Imipenem Infections International economic relations Klebsiella Laboratories Neonates Obstetrics Pathogenesis Piperacillin Piperacillin-tazobactam Population Pre-eclampsia Preeclampsia Pregnancy Pregnant women Reproductive health Sample size Software Tazobactam Urinary tract Urinary tract diseases Urinary tract infections Urine Urogenital system Womens health |
| title | Urinary Tract Infections and Preeclampsia among Pregnant Women Attending Two Hospitals in Mwanza City, Tanzania: A 1:2 Matched Case-Control Study |
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