Functional analysis of clinical response to low-dose IL-2 in patients with refractory chronic graft-versus-host disease

Patients with chronic graft-versus-host disease (cGVHD) have a paucity of regulatory CD4 T cells (CD4Tregs) that mediate peripheral tolerance. In clinical trials, daily low-dose interleukin-2 (IL-2) has been administered safely for prolonged periods in patients with steroid-refractory cGVHD. Periphe...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Blood advances 2019-04, Vol.3 (7), p.984-994
Hauptverfasser:	Whangbo, Jennifer S., Kim, Haesook T., Nikiforow, Sarah, Koreth, John, Alho, Ana C., Falahee, Bryn, Kim, Soomin, Dusenbury, Katharine, Fields, Marie J., Reynolds, Carol G., Alyea, Edwin P., Armand, Philippe, Cutler, Corey S., Ho, Vincent T., Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome
Format:	Artikel
Sprache:	eng
Schlagworte:	Transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!